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Study · Ex vivo tissue · 2007

6 results

The effect of tripeptide-copper complex on human hair growth in vitro.

Pyo HK, Yoo HG, Won CH, Lee SH, Kang YJ, Eun HC, Cho KH, Kim KH

Archives of pharmacal research1 Jul 2007Cited by 31 (Europe PMC)

PMID17703734 (opens in a new tab)DOI10.1007/bf02978833 (opens in a new tab)PepBankPUB-17703734
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In ex vivo human hair follicles, AHK‑Cu stimulated elongation.

    In plain wordsIn lab tests, AHK‑Cu stimulated human hair follicle elongation.

    Peptide
    AHK-Cu (Ala-His-Lys copper complex)
    Outcome
    IncreaseHair follicle elongation
    Study

    humann: not reported in source

    human hair follicles
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    10(-12) - 10(-9) MAs given in this study (human).

    Source sentences

    Summary
    AHK-Cu (10(-12) - 10(-9) M) stimulated the elongation of human hair follicles ex vivo and the proliferation of DPCs in vitro.
    1 context sentence
    Summary · context
    In the present study, the effects of L-alanyl-L-histidyl-L-lysine-Cu2+ (AHK-Cu) on human hair growth ex vivo and cultured dermal papilla cells were evaluated.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured dermal papilla cells, AHK‑Cu stimulated proliferation.

    In plain wordsIn cells, AHK‑Cu stimulated dermal papilla cell growth.

    Peptide
    AHK-Cu (Ala-His-Lys copper complex)
    Outcome
    IncreaseDPC proliferation
    Study

    humann: not reported in source

    cultured dermal papilla cells
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    10(-12) - 10(-9) MAs given in this study (human).

    Source sentences

    Summary
    AHK-Cu (10(-12) - 10(-9) M) stimulated the elongation of human hair follicles ex vivo and the proliferation of DPCs in vitro.
    1 context sentence
    Summary · context
    In the present study, the effects of L-alanyl-L-histidyl-L-lysine-Cu2+ (AHK-Cu) on human hair growth ex vivo and cultured dermal papilla cells were evaluated.
  3. 03LabIn vitro (cells)Mechanism

    In cultured dermal papilla cells, AHK‑Cu reduced apoptotic cell numbers without statistical significance.

    In plain wordsIn cells, AHK‑Cu did not significantly reduce dermal papilla cell death.

    Peptide
    AHK-Cu (Ala-His-Lys copper complex)
    Outcome
    No significant changeDPC apoptosis
    Study

    humann: not reported in source

    cultured dermal papilla cells
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    10(-9) MAs given in this study (human).

    Source sentences

    Summary
    Annexin V-fluorescein isothiocyanate/propidium iodide labeling and flow cytometric analysis showed that 10(-9) M AHK-Cu reduced the number of apoptotic DPCs, but this decrease was not statistically significant.
    1 context sentence
    Summary · context
    In the present study, the effects of L-alanyl-L-histidyl-L-lysine-Cu2+ (AHK-Cu) on human hair growth ex vivo and cultured dermal papilla cells were evaluated.
  4. 04LabIn vitro (cells)Mechanism

    In cultured dermal papilla cells, AHK‑Cu elevated the Bcl-2/Bax ratio.

    In plain wordsIn cells, AHK‑Cu increased the Bcl-2/Bax ratio.

    Peptide
    AHK-Cu (Ala-His-Lys copper complex)
    Outcome
    IncreaseBcl-2/Bax ratio
    Study

    humann: not reported in source

    cultured dermal papilla cells
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    10(-9) MAs given in this study (human).

    Source sentences

    Summary
    The ratio of Bcl-2/Bax was elevated, and the levels of the cleaved forms of caspase-3 and PARP were reduced by treatment with 10(-9) M AHK-Cu.
    1 context sentence
    Summary · context
    In the present study, the effects of L-alanyl-L-histidyl-L-lysine-Cu2+ (AHK-Cu) on human hair growth ex vivo and cultured dermal papilla cells were evaluated.
  5. 05LabIn vitro (cells)Mechanism

    In cultured dermal papilla cells, AHK‑Cu reduced cleaved caspase-3 levels.

    In plain wordsIn cells, AHK‑Cu reduced cleaved caspase-3 levels.

    Peptide
    AHK-Cu (Ala-His-Lys copper complex)
    Outcome
    DecreaseCleaved caspase-3
    Study

    humann: not reported in source

    cultured dermal papilla cells
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    10(-9) MAs given in this study (human).

    Source sentences

    Summary
    The ratio of Bcl-2/Bax was elevated, and the levels of the cleaved forms of caspase-3 and PARP were reduced by treatment with 10(-9) M AHK-Cu.
    1 context sentence
    Summary · context
    In the present study, the effects of L-alanyl-L-histidyl-L-lysine-Cu2+ (AHK-Cu) on human hair growth ex vivo and cultured dermal papilla cells were evaluated.
  6. 06LabIn vitro (cells)Mechanism

    In cultured dermal papilla cells, AHK‑Cu reduced cleaved PARP levels.

    In plain wordsIn cells, AHK‑Cu reduced cleaved PARP levels.

    Peptide
    AHK-Cu (Ala-His-Lys copper complex)
    Outcome
    DecreaseCleaved PARP
    Study

    humann: not reported in source

    cultured dermal papilla cells
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    10(-9) MAs given in this study (human).

    Source sentences

    Summary
    The ratio of Bcl-2/Bax was elevated, and the levels of the cleaved forms of caspase-3 and PARP were reduced by treatment with 10(-9) M AHK-Cu.
    1 context sentence
    Summary · context
    In the present study, the effects of L-alanyl-L-histidyl-L-lysine-Cu2+ (AHK-Cu) on human hair growth ex vivo and cultured dermal papilla cells were evaluated.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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