Differential activation of the sympathetic innervation of adipose tissues by melanocortin receptor stimulation.

Brito MN, Brito NA, Baro DJ, Song CK, Bartness TJ

Endocrinology16 Aug 2007Cited by 148 (Europe PMC)

PMID17702843DOI10.1210/en.2007-0621PepBankPUB-17702843

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In Siberian hamsters, central melanotan II increased norepinephrine turnover in inguinal WAT, dorsosubcutaneous WAT and interscapular brown adipose tissue.
In plain wordsIn hamsters, melanotan II given into the brain increased nerve activity to some fat tissues.
Peptide
Melanotan II
Outcome
IncreaseSympathetic drive (NETO) to inguinal WAT, dorsosubcutaneous WAT and IBAT
Study
Siberian hamstern: not reported in source
Siberian hamsters
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated · third ventricular injectionAs given in this study (Siberian hamster).
Source sentences
Summary
Centrally administered MTII provoked differential sympathetic drives to WAT and IBAT (increased inguinal WAT, dorsosubcutaneous WAT and IBAT NETO, but not epididymal WAT and retroperitoneal WAT NETO).
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, we tested whether third ventricular injections of MTII increased sympathetic drive to WAT and interscapular brown adipose tissue (IBAT) using norepinephrine turnover (NETO) as a measure of sympathetic drive.
Report a problemFND-1770284301
02AnimalAnimal study (in vivo)Mechanism
In Siberian hamsters, central melanotan II did not increase norepinephrine turnover in epididymal or retroperitoneal WAT.
In plain wordsIn hamsters, melanotan II given into the brain did not increase nerve activity to two other fat depots.
Peptide
Melanotan II
Outcome
No significant changeSympathetic drive (NETO) to epididymal and retroperitoneal WAT
Study
Siberian hamstern: not reported in source
Siberian hamsters
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated · third ventricular injectionAs given in this study (Siberian hamster).
Source sentences
Summary
Centrally administered MTII provoked differential sympathetic drives to WAT and IBAT (increased inguinal WAT, dorsosubcutaneous WAT and IBAT NETO, but not epididymal WAT and retroperitoneal WAT NETO).
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, we tested whether third ventricular injections of MTII increased sympathetic drive to WAT and interscapular brown adipose tissue (IBAT) using norepinephrine turnover (NETO) as a measure of sympathetic drive.
Report a problemFND-1770284302
03AnimalAnimal study (in vivo)Efficacy outcome
In Siberian hamsters, melanotan II increased circulating free fatty acids and glycerol.
In plain wordsIn hamsters, melanotan II raised blood levels of fat breakdown products.
Peptide
Melanotan II
Outcome
IncreaseCirculating free fatty acids and glycerol
Study
Siberian hamstern: not reported in source
Siberian hamsters
Outcome group
Lipids · Metabolic and weight
Studied dose
Dose not stated · third ventricular injectionAs given in this study (Siberian hamster).
Source sentences
Summary
MTII also increased circulating concentrations of the lipolytic products free fatty acids and glycerol
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, we tested whether third ventricular injections of MTII increased sympathetic drive to WAT and interscapular brown adipose tissue (IBAT) using norepinephrine turnover (NETO) as a measure of sympathetic drive.
Report a problemFND-1770284303
04AnimalAnimal study (in vivo)Mechanism
In Siberian hamsters, melanotan II did not change plasma catecholamines.
In plain wordsIn hamsters, melanotan II did not change blood catecholamine levels.
Peptide
Melanotan II
Outcome
No significant changePlasma catecholamines
Study
Siberian hamstern: not reported in source
Siberian hamsters
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated · third ventricular injectionAs given in this study (Siberian hamster).
Source sentences
Summary
MTII also increased circulating concentrations of the lipolytic products free fatty acids and glycerol but not plasma catecholamines, suggesting lipid mobilization via WAT SNS innervation and not via adrenal medullary catecholamines.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, we tested whether third ventricular injections of MTII increased sympathetic drive to WAT and interscapular brown adipose tissue (IBAT) using norepinephrine turnover (NETO) as a measure of sympathetic drive.
Report a problemFND-1770284304
05AnimalAnimal study (in vivo)Mechanism
In Siberian hamsters, acute melanotan II treatment largely left WAT and IBAT gene expression unchanged.
In plain wordsIn hamsters, a single melanotan II treatment mostly did not change gene activity in fat tissue.
Peptide
Melanotan II
Outcome
No significant changeWAT and IBAT gene expression
Study
Siberian hamstern: not reported in source
Siberian hamsters
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated · third ventricular injectionAs given in this study (Siberian hamster).
Source sentences
Summary
WAT or IBAT gene expression was largely unaffected by acute MTII treatment
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, we tested whether third ventricular injections of MTII increased sympathetic drive to WAT and interscapular brown adipose tissue (IBAT) using norepinephrine turnover (NETO) as a measure of sympathetic drive.
Report a problemFND-1770284305
06AnimalAnimal study (in vivo)Efficacy outcome
In Siberian hamsters, melanotan II increased interscapular brown adipose tissue temperature.
In plain wordsIn hamsters, melanotan II raised the temperature of brown fat.
Peptide
Melanotan II
Outcome
IncreaseIBAT temperature
Study
Siberian hamstern: not reported in source
Siberian hamsters
Outcome group
Receptor activity and mechanism · Metabolic and weight
Studied dose
Dose not stated · third ventricular injectionAs given in this study (Siberian hamster).
Source sentences
Summary
IBAT temperature was increased by MTII and the MC4-R agonist and decreased by agouti-related protein.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, we tested whether third ventricular injections of MTII increased sympathetic drive to WAT and interscapular brown adipose tissue (IBAT) using norepinephrine turnover (NETO) as a measure of sympathetic drive.
Report a problemFND-1770284306

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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