Effects of an acute stressor on blood pressure and heart rate in rats pretreated with intracerebroventricular oxytocin injections.

Petersson M, Uvnäs-Moberg K

Psychoneuroendocrinology14 Aug 2007Cited by 31 (Europe PMC)

PMID17698297DOI10.1016/j.psyneuen.2007.06.015PepBankPUB-17698297

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In male rats, repeated intracerebroventricular oxytocin reduced systolic and diastolic blood pressure.
In plain wordsIn male rats, oxytocin injected into the brain on 5 days lowered blood pressure.
Peptide
Oxytocin
Outcome
DecreaseBlood pressure after repeated oxytocin
Study
ratn: not reported in source
Male rats, repeated ICV oxytocin
Comparator
Controls
Outcome group
Blood pressure · Cardiovascular
Studied dose
0.3 µg · intracerebroventricular · 5 daysAs given in this study (rat).
Source sentences
Summary
The oxytocin treatment reduced blood pressure significantly (systolic: 108+/-4.6 vs. 121+/-1.8, p<0.01, diastolic: 96+/-5.1 vs. 108+/-3.0, p<0.01)
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose oxytocin (0.3 microg, ICV) was administered to male rats once a day during 5 days.
Report a problemFND-1769829701
02AnimalAnimal study (in vivo)Efficacy outcome
In male rats, repeated intracerebroventricular oxytocin did not change heart rate.
In plain wordsIn male rats, oxytocin injected into the brain on 5 days did not change heart rate.
Peptide
Oxytocin
Outcome
No significant changeHeart rate after repeated oxytocin
Study
ratn: not reported in source
Male rats, repeated ICV oxytocin
Comparator
Controls
Outcome group
Heart function · Cardiovascular
Studied dose
0.3 µg · intracerebroventricular · 5 daysAs given in this study (rat).
Source sentences
Summary
whereas heart rate remained unchanged.
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose oxytocin (0.3 microg, ICV) was administered to male rats once a day during 5 days.
Report a problemFND-1769829702
03AnimalAnimal study (in vivo)Efficacy outcome
In oxytocin-treated rats, systolic and diastolic blood pressure rose after an alarm noise to the level of controls.
In plain wordsIn rats given oxytocin, blood pressure rose after a sudden alarm noise to the level of untreated rats.
Peptide
Oxytocin
Outcome
IncreaseBlood pressure response to alarm noise
Study
ratn: not reported in source
Male rats, repeated ICV oxytocin
Comparator
Controls
Outcome group
Blood pressure · Cardiovascular
Studied dose
0.3 µg · intracerebroventricular · 5 daysAs given in this study (rat).
Source sentences
Summary
In contrast, systolic and diastolic blood pressure increased significantly after the exposure to the ringing alarm clock in the oxytocin-treated rats (p<0.05), and became equal to the blood pressure in controls.
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose oxytocin (0.3 microg, ICV) was administered to male rats once a day during 5 days.
Report a problemFND-1769829703
04AnimalAnimal study (in vivo)Efficacy outcome
In oxytocin-treated rats, heart rate rose and stayed higher than in controls during 30 min after an alarm noise.
In plain wordsIn rats given oxytocin, heart rate rose after a sudden alarm noise and stayed higher than in untreated rats.
Peptide
Oxytocin
Outcome
IncreaseHeart rate response to alarm noise
Study
ratn: not reported in source
Male rats, repeated ICV oxytocin
Comparator
Controls
Outcome group
Heart function · Cardiovascular
Studied dose
0.3 µg · intracerebroventricular · 5 daysAs given in this study (rat).
Source sentences
Summary
In addition, heart rate increased and stayed significantly higher in the oxytocin-treated rats compared to the controls during the 30 min observation period (ANOVA p<0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose oxytocin (0.3 microg, ICV) was administered to male rats once a day during 5 days.
Report a problemFND-1769829704
05AnimalAnimal study (in vivo)Efficacy outcome
Twenty-four hours after the stressor, blood pressure was again lower in oxytocin-treated rats than in controls.
In plain wordsA day after the noise, rats given oxytocin again had lower blood pressure than untreated rats.
Peptide
Oxytocin
Outcome
DecreaseBlood pressure 24 hours after the stressor
Study
ratn: not reported in source
Male rats, repeated ICV oxytocin
Comparator
Controls
Outcome group
Blood pressure · Cardiovascular
Studied dose
0.3 µg · intracerebroventricular · 5 daysAs given in this study (rat).
Source sentences
Summary
Twenty-four hours later, blood pressure was again significantly lower in the oxytocin-treated rats compared to controls (p<0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
For this purpose oxytocin (0.3 microg, ICV) was administered to male rats once a day during 5 days.
Report a problemFND-1769829705

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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