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Study · Animal study (in vivo) · rat · 2007

5 results

Insights into a role of GH secretagogues in reversing the age-related decline in the GH/IGF-I axis.

Frutos MG, Cacicedo L, Fernández C, Vicent D, Velasco B, Zapatero H, Sánchez-Franco F

American journal of physiology. Endocrinology and metabolism7 Aug 2007Cited by 20 (Europe PMC)

PMID17684105 (opens in a new tab)DOI10.1152/ajpendo.00236.2007 (opens in a new tab)PepBankPUB-17684105
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, GHRP‑6 restored GH secretion to levels in young untreated rats.

    In plain wordsIn rats, GHRP‑6 restored growth hormone secretion in old animals to levels in young untreated animals.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH secretion
    Study

    ratn: not reported in source

    Old male Wistar rats
    Comparator
    Young untreated rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In old rats, growth hormone-releasing peptide-6 returned the levels of GH and IGF-I secretion and liver IGF-I mRNA, and partially restored the lower pituitary IR-GH and GH mRNA levels to those of young untreated rats.
    1 context sentence
    Summary · context
    Two groups of male Wistar rats were studied: young-adult (3 mo) and old (24 mo).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, GHRP‑6 restored IGF-I secretion to levels in young untreated rats.

    In plain wordsIn rats, GHRP‑6 restored IGF-I secretion in old animals to levels in young untreated animals.

    Peptide
    GHRP-6
    Outcome
    IncreaseIGF-I secretion
    Study

    ratn: not reported in source

    Old male Wistar rats
    Comparator
    Young untreated rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In old rats, growth hormone-releasing peptide-6 returned the levels of GH and IGF-I secretion and liver IGF-I mRNA, and partially restored the lower pituitary IR-GH and GH mRNA levels to those of young untreated rats.
    1 context sentence
    Summary · context
    Two groups of male Wistar rats were studied: young-adult (3 mo) and old (24 mo).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, GHRP‑6 restored liver IGF-I mRNA to levels in young untreated rats.

    In plain wordsIn rats, GHRP‑6 restored liver IGF-I gene expression in old animals to levels in young untreated animals.

    Peptide
    GHRP-6
    Outcome
    IncreaseLiver IGF-I mRNA
    Study

    ratn: not reported in source

    Old male Wistar rats
    Comparator
    Young untreated rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In old rats, growth hormone-releasing peptide-6 returned the levels of GH and IGF-I secretion and liver IGF-I mRNA, and partially restored the lower pituitary IR-GH and GH mRNA levels to those of young untreated rats.
    1 context sentence
    Summary · context
    Two groups of male Wistar rats were studied: young-adult (3 mo) and old (24 mo).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, GHRP‑6 partially restored reduced pituitary immunoreactive GH toward levels in young untreated rats.

    In plain wordsIn rats, GHRP‑6 partly restored pituitary growth hormone in old animals toward levels in young untreated animals.

    Peptide
    GHRP-6
    Outcome
    IncreasePituitary immunoreactive GH
    Study

    ratn: not reported in source

    Old male Wistar rats
    Comparator
    Young untreated rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In old rats, growth hormone-releasing peptide-6 returned the levels of GH and IGF-I secretion and liver IGF-I mRNA, and partially restored the lower pituitary IR-GH and GH mRNA levels to those of young untreated rats.
    1 context sentence
    Summary · context
    Two groups of male Wistar rats were studied: young-adult (3 mo) and old (24 mo).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, GHRP‑6 partially restored reduced pituitary GH mRNA toward levels in young untreated rats.

    In plain wordsIn rats, GHRP‑6 partly restored pituitary growth hormone gene expression in old animals toward levels in young untreated animals.

    Peptide
    GHRP-6
    Outcome
    IncreasePituitary GH mRNA
    Study

    ratn: not reported in source

    Old male Wistar rats
    Comparator
    Young untreated rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In old rats, growth hormone-releasing peptide-6 returned the levels of GH and IGF-I secretion and liver IGF-I mRNA, and partially restored the lower pituitary IR-GH and GH mRNA levels to those of young untreated rats.
    1 context sentence
    Summary · context
    Two groups of male Wistar rats were studied: young-adult (3 mo) and old (24 mo).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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