In isolated adipocytes and skeletal muscles from IRAP-deficient mice, oxytocin was not processed from the NH2 terminus.
In plain wordsIn lab tests on tissue from mice lacking IRAP, oxytocin was not cut at its start end.
- Peptide
- Oxytocin
- Outcome
- Not applicableNH2-terminal processing of oxytocin by IRAP-deficient tissue
- Study
mousen: not reported in source
Isolated adipocytes and skeletal muscles from IRAP-/- mice- Comparator
- Control mice
- Outcome group
- Pharmacokinetics · Pharmacology
- Studied dose
- Dose not stated
Source sentences
We found that vasopressin and oxytocin were not processed from the NH(2) terminus by isolated IRAP(-/-) adipocytes and skeletal muscles.
1 context sentence(design, population, supporting numbers)
In the present study, to identify in vivo substrates for IRAP, we tested potential substrates for cleavage by IRAP-deficient (IRAP(-/-)) and control mice.