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Study · Ex vivo tissue · bovine · 2007

4 results

Effects of IGF-I bioavailability on bovine preantral follicular development in vitro.

Thomas FH, Campbell BK, Armstrong DG, Telfer EE

Reproduction (Cambridge, England)1 Jun 2007Cited by 63 (Europe PMC)

PMID17636166 (opens in a new tab)DOI10.1530/rep-06-0382 (opens in a new tab)PepBankPUB-17636166
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In cultured bovine preantral follicles, LR3 IGF-I and hrIGF-I both increased follicle diameter in a dose-dependent manner.

    In plain wordsIn lab tests, bovine follicles grew larger with LR3 IGF-I and with human recombinant IGF-I, and larger doses gave more growth.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseFollicle diameter
    Study

    bovinen: not reported in source

    Preantral follicle culture
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    increasing doses · 6 daysAs given in this study (bovine).

    Source sentences

    Summary
    Both types of IGF-I increased follicle diameter in a dose-dependent manner (P < 0.05) and increased estradiol production over control levels (P < 0.05).
    1 context sentence
    Summary · context
    Bovine preantral follicles were cultured for 6 days in serum-free medium with increasing doses of Long R3 (LR3) IGF-I (an analog with low affinity for IGF-binding proteins (IGFBPs)), or human recombinant IGF-I (hrIGF-I).
  2. 02LabEx vivo tissueEfficacy outcome

    In cultured bovine preantral follicles, LR3 IGF-I and hrIGF-I both increased estradiol production over control levels.

    In plain wordsIn lab tests, bovine follicles made more estradiol with LR3 IGF-I and with human recombinant IGF-I than control follicles.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseEstradiol production
    Study

    bovinen: not reported in source

    Preantral follicle culture
    Comparator
    Control
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 daysAs given in this study (bovine).

    Source sentences

    Summary
    Both types of IGF-I increased follicle diameter in a dose-dependent manner (P < 0.05) and increased estradiol production over control levels (P < 0.05).
    1 context sentence
    Summary · context
    Bovine preantral follicles were cultured for 6 days in serum-free medium with increasing doses of Long R3 (LR3) IGF-I (an analog with low affinity for IGF-binding proteins (IGFBPs)), or human recombinant IGF-I (hrIGF-I).
  3. 03LabEx vivo tissueEfficacy outcome

    In cultured bovine preantral follicles, LR3 IGF-I gave smaller oocyte/follicle diameter ratios than controls or physiological concentrations of hrIGF-I.

    In plain wordsIn lab tests, bovine follicles treated with LR3 IGF-I had smaller oocyte-to-follicle ratios than controls or follicles with normal hrIGF-I doses.

    Peptide
    IGF-1 LR3
    Outcome
    DecreaseOocyte/follicle diameter ratio
    Study

    bovinen: not reported in source

    Preantral follicle culture
    Comparator
    Controls or physiological hrIGF-I
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 daysAs given in this study (bovine).

    Source sentences

    Summary
    follicles treated with LR3 IGF-I and the highest concentration of hrIGF-I (1000 ng/ml) had smaller oocyte/follicle ratios, and increased oocyte degeneration, compared with controls or follicles treated with physiological concentrations of hrIGF-I (P < 0.05)
    1 context sentence
    Summary · context
    Bovine preantral follicles were cultured for 6 days in serum-free medium with increasing doses of Long R3 (LR3) IGF-I (an analog with low affinity for IGF-binding proteins (IGFBPs)), or human recombinant IGF-I (hrIGF-I).
  4. 04LabEx vivo tissueSafety outcome

    In cultured bovine preantral follicles, LR3 IGF-I increased oocyte degeneration compared with controls or physiological concentrations of hrIGF-I.

    In plain wordsIn lab tests, more oocytes degenerated in bovine follicles treated with LR3 IGF-I than in controls or follicles with normal hrIGF-I doses.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseOocyte degeneration
    Study

    bovinen: not reported in source

    Preantral follicle culture
    Comparator
    Controls or physiological hrIGF-I
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 daysAs given in this study (bovine).

    Source sentences

    Summary
    follicles treated with LR3 IGF-I and the highest concentration of hrIGF-I (1000 ng/ml) had smaller oocyte/follicle ratios, and increased oocyte degeneration, compared with controls or follicles treated with physiological concentrations of hrIGF-I (P < 0.05)
    1 context sentence
    Summary · context
    Bovine preantral follicles were cultured for 6 days in serum-free medium with increasing doses of Long R3 (LR3) IGF-I (an analog with low affinity for IGF-binding proteins (IGFBPs)), or human recombinant IGF-I (hrIGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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