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Study · Animal study (in vivo) · mouse and rat · 2007

4 results

Brain delivery of vasoactive intestinal peptide enhanced with the nanoparticles conjugated with wheat germ agglutinin following intranasal administration.

Gao X, Wu B, Zhang Q, Chen J, Zhu J, Zhang W, Rong Z, Chen H, Jiang X

Journal of controlled release : official journal of the Controlled Release Society2 Jun 2007Cited by 128 (Europe PMC)

PMID17628165 (opens in a new tab)DOI10.1016/j.jconrel.2007.05.026 (opens in a new tab)PepBankPUB-17628165
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In mice, intranasal VIP carried by nanoparticles raised the brain AUC of intact VIP by 3.5 to 4.7 fold versus VIP solution.

    In plain wordsIn mice, VIP carried by nanoparticles reached the brain at 3.5 to 4.7 times the level of plain VIP solution.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseBrain AUC of intact 125I-VIP with PEG-PLA nanoparticles
    Study

    mousen: not reported in source

    Intranasal dosing in mice
    Comparator
    VIP solution
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intranasalAs given in this study (mouse).

    Measurements

    Brain AUC fold increase
    3.5 to 4.7 fold
    nanoparticles versus solution

    Source sentences

    Summary
    The area under the concentration-time curve of intact 125I-vasoactive intestinal peptide in brain of mice following the intranasal administration of 125I-vasoactive intestinal peptide carried by nanoparticles and wheat germ agglutinin-conjugated ones was significantly enlarged by 3.5 approximately 4.7 folds
    2 context sentences
    Summary · context
    compared with that after intranasal application of 125I-vasoactive intestinal peptide solution.
    Summary · context
    In the present study, vasoactive intestinal peptide, a neuroprotective peptide, was efficiently incorporated into the poly (ethylene glycol)-poly (lactic acid) nanoparticles modified with wheat germ agglutinin and the biodistribution, brain uptake and neuroprotective effect of the formulation were assessed.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In mice, intranasal VIP carried by wheat germ agglutinin-conjugated nanoparticles raised the brain AUC of intact VIP by 5.6 to 7.7 fold versus VIP solution.

    In plain wordsIn mice, VIP carried by wheat germ agglutinin-coated nanoparticles reached the brain at 5.6 to 7.7 times the level of plain VIP solution.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseBrain AUC of intact 125I-VIP with WGA-conjugated nanoparticles
    Study

    mousen: not reported in source

    Intranasal dosing in mice
    Comparator
    VIP solution
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · intranasalAs given in this study (mouse).

    Measurements

    Brain AUC fold increase
    5.6 to 7.7 fold
    WGA nanoparticles versus solution

    Source sentences

    Summary
    and wheat germ agglutinin-conjugated ones was significantly enlarged by 3.5 approximately 4.7 folds and 5.6 approximately 7.7 folds, respectively, compared with that after intranasal application of 125I-vasoactive intestinal peptide solution.
    1 context sentence
    Summary · context
    In the present study, vasoactive intestinal peptide, a neuroprotective peptide, was efficiently incorporated into the poly (ethylene glycol)-poly (lactic acid) nanoparticles modified with wheat germ agglutinin and the biodistribution, brain uptake and neuroprotective effect of the formulation were assessed.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In ethylcholine aziridium-treated rats, intranasal VIP in unmodified nanoparticles at 25 microg/kg improved spatial memory.

    In plain wordsIn rats with induced memory impairment, nasal VIP in nanoparticles at 25 microg/kg improved spatial memory.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseSpatial memory with VIP-loaded unmodified nanoparticles
    Study

    ratn: not reported in source

    Ethylcholine aziridium-treated rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    25 microg/kg · intranasalAs given in this study (rat).

    Source sentences

    Summary
    The same improvements in spatial memory in ethylcholine aziridium-treated rats were observed following intranasal administration of 25 microg/kg and 12.5 microg/kg of vasoactive intestinal peptide loaded by unmodified nanoparticles
    1 context sentence
    Summary · context
    In the present study, vasoactive intestinal peptide, a neuroprotective peptide, was efficiently incorporated into the poly (ethylene glycol)-poly (lactic acid) nanoparticles modified with wheat germ agglutinin and the biodistribution, brain uptake and neuroprotective effect of the formulation were assessed.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In ethylcholine aziridium-treated rats, intranasal VIP in wheat germ agglutinin-modified nanoparticles at 12.5 microg/kg improved spatial memory.

    In plain wordsIn rats with induced memory impairment, nasal VIP in coated nanoparticles at 12.5 microg/kg improved spatial memory.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseSpatial memory with VIP-loaded WGA-modified nanoparticles
    Study

    ratn: not reported in source

    Ethylcholine aziridium-treated rats
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    12.5 microg/kg · intranasalAs given in this study (rat).

    Source sentences

    Summary
    The same improvements in spatial memory
    2 context sentences
    Summary · context
    12.5 microg/kg of vasoactive intestinal peptide loaded by unmodified nanoparticles
    Summary · context
    In the present study, vasoactive intestinal peptide, a neuroprotective peptide, was efficiently incorporated into the poly (ethylene glycol)-poly (lactic acid) nanoparticles modified with wheat germ agglutinin and the biodistribution, brain uptake and neuroprotective effect of the formulation were assessed.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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