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Study · Ex vivo tissue · rat · 2007

2 results

Thyrotrophin-releasing hormone, vasoactive intestinal peptide, prolactin-releasing peptide and dopamine regulation of prolactin secretion by different lactotroph morphological subtypes in the rat.

Christian HC, Chapman LP, Morris JF

Journal of neuroendocrinology1 Aug 2007Cited by 33 (Europe PMC)

PMID17620102 (opens in a new tab)DOI10.1111/j.1365-2826.2007.01567.x (opens in a new tab)PepBankPUB-17620102
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In rat pituitary segments, VIP increased prolactin granule exocytosis from type II and III lactotrophs.

    In plain wordsIn rat pituitary tissue, VIP increased the release of prolactin granules from two of three lactotroph cell types.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseProlactin granule exocytosis from type II and III lactotrophs
    Study

    ratn: not reported in source

    Rat anterior pituitary segments
    Comparator
    Medium with tannic acid, no peptide
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1-10 nMAs given in this study (rat).

    Source sentences

    Summary
    VIP (1-10 nM), TRH (10 nM) and PrRP-31 (10 nM) all caused a significant increase (P < 0.05) in the amount of PRL granule exocytosis from type II and III lactotrophs
    1 context sentence
    Summary · context
    Pituitary segments were incubated in medium containing tannic acid (to capture exocytosis of secretory granules), either alone or with secretagogue peptide.
  2. 02LabEx vivo tissueEfficacy outcome

    In rat pituitary segments, VIP had no effect on prolactin exocytosis from type I lactotrophs.

    In plain wordsIn rat pituitary tissue, VIP did not change prolactin granule release from type I lactotroph cells.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeProlactin granule exocytosis from type I lactotrophs
    Study

    ratn: not reported in source

    Rat anterior pituitary segments
    Comparator
    Medium with tannic acid, no peptide
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1-10 nMAs given in this study (rat).

    Source sentences

    Summary
    but had no effect on PRL exocytosis from type I.
    1 context sentence
    Summary · context
    Pituitary segments were incubated in medium containing tannic acid (to capture exocytosis of secretory granules), either alone or with secretagogue peptide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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