Extracellular amino acid levels in the paraventricular nucleus and the central amygdala in high- and low-anxiety dams rats during maternal aggression: regulation by oxytocin.

Bosch OJ, Sartori SB, Singewald N, Neumann ID

Stress (Amsterdam, Netherlands)1 Aug 2007Cited by 25 (Europe PMC)

PMID17613940DOI10.1080/10253890701223197PepBankPUB-17613940

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In lactating LAB rats, local infusion of an oxytocin receptor antagonist increased extracellular glutamate and aspartate in the central amygdala.
In plain wordsIn low-anxiety mother rats, blocking oxytocin receptors in the amygdala raised glutamate and aspartate levels.
Peptide
Oxytocin
Outcome
IncreaseCeA glutamate and aspartate with oxytocin antagonist in LAB dams
Study
ratn: not reported in source
Lactating HAB and LAB dams, microdialysis
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Source sentences
Summary
Infusion of a selective OTA increased the concentrations of glutamate and aspartate in LAB dams and GABA in HAB dams.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the dynamic changes in extracellular concentrations of the amino acids aspartate, glutamate, gamma-aminobutyric acid (GABA), serine, histidine, arginine and taurine in the PVN and CeA in lactating rats bred for high (HAB) and low (LAB) anxiety-related behavior under basal condi…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1761394001
02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In lactating HAB rats, local infusion of an oxytocin receptor antagonist increased extracellular GABA in the central amygdala.
In plain wordsIn high-anxiety mother rats, blocking oxytocin receptors in the amygdala raised GABA levels.
Peptide
Oxytocin
Outcome
IncreaseCeA GABA with oxytocin antagonist in HAB dams
Study
ratn: not reported in source
Lactating HAB and LAB dams, microdialysis
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Source sentences
Summary
Infusion of a selective OTA increased the concentrations of glutamate and aspartate in LAB dams and GABA in HAB dams.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the dynamic changes in extracellular concentrations of the amino acids aspartate, glutamate, gamma-aminobutyric acid (GABA), serine, histidine, arginine and taurine in the PVN and CeA in lactating rats bred for high (HAB) and low (LAB) anxiety-related behavior under basal condi…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1761394002
03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In OTA-treated HAB and LAB dams, taurine levels increased during maternal aggression.
In plain wordsIn mother rats given an oxytocin receptor blocker, taurine levels rose during maternal aggression.
Peptide
Oxytocin
Outcome
IncreaseTaurine during maternal aggression with oxytocin antagonist
Study
ratn: not reported in source
Lactating HAB and LAB dams, microdialysis
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Source sentences
Summary
In OTA-treated HAB and LAB dams taurine levels increased during maternal aggression.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the dynamic changes in extracellular concentrations of the amino acids aspartate, glutamate, gamma-aminobutyric acid (GABA), serine, histidine, arginine and taurine in the PVN and CeA in lactating rats bred for high (HAB) and low (LAB) anxiety-related behavior under basal condi…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1761394003
04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In highly aggressive HAB dams, local oxytocin antagonist administration attenuated the increase in paraventricular serine.
In plain wordsIn high-anxiety mother rats, blocking oxytocin receptors reduced the rise in serine in the paraventricular nucleus.
Peptide
Oxytocin
Outcome
DecreasePVN serine increase in HAB dams with oxytocin antagonist
Study
ratn: not reported in source
Lactating HAB and LAB dams, microdialysis
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Source sentences
Summary
Within the PVN, the highly-aggressive HAB dams showed a more pronounced increase in aspartate and serine levels; the latter being attenuated by local OTA administration.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the dynamic changes in extracellular concentrations of the amino acids aspartate, glutamate, gamma-aminobutyric acid (GABA), serine, histidine, arginine and taurine in the PVN and CeA in lactating rats bred for high (HAB) and low (LAB) anxiety-related behavior under basal condi…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1761394004
05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In LAB dams, the oxytocin antagonist did not affect the level of any amino acid in the paraventricular nucleus.
In plain wordsIn low-anxiety mother rats, blocking oxytocin receptors did not change any amino acid level in the paraventricular nucleus.
Peptide
Oxytocin
Outcome
No significant changePVN amino acids with oxytocin antagonist in LAB dams
Study
ratn: not reported in source
Lactating HAB and LAB dams, microdialysis
Outcome group
Neurotransmitters and neurotrophic factors · Nervous system and cognition
Source sentences
Summary
However, OTA did not affect the level of any amino acid in the LAB dams.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we investigated the dynamic changes in extracellular concentrations of the amino acids aspartate, glutamate, gamma-aminobutyric acid (GABA), serine, histidine, arginine and taurine in the PVN and CeA in lactating rats bred for high (HAB) and low (LAB) anxiety-related behavior under basal condi…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1761394005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

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