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Study · In vitro (cells) · 2007

7 results

In vitro observations on the influence of copper peptide aids for the LED photoirradiation of fibroblast collagen synthesis.

Huang PJ, Huang YC, Su MF, Yang TY, Huang JR, Jiang CP

Photomedicine and laser surgery1 Jun 2007Cited by 26 (Europe PMC)

PMID17603859 (opens in a new tab)DOI10.1089/pho.2007.2062 (opens in a new tab)PepBankPUB-17603859
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human fibroblasts, LED photoirradiation plus Cu-GHK increased bFGF secretion compared with LED photoirradiation alone.

    In plain wordsIn cells, red light plus Cu-GHK raised bFGF release more than red light alone.

    Peptide
    GHK-Cu
    Outcome
    IncreasebFGF secretion
    Study

    humann: not reported in source

    Human fibroblasts (HS68)
    Comparator
    LED-PI alone
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Measurements

    bFGF secretion increase
    ≈ 230%
    vs LED-PI alone

    Source sentences

    Summary
    The combinative effects of LED-PI and Cu-GHK led to an increase not only in bFGF secretion (approximately 230%)
    2 context sentences
    Summary · context
    Cell activity/viability, procollagen type I C-peptide (P1CP), and bFGF were evaluated in vitro with human fibroblasts (HS68).
    Summary · context
    The effects of single factors (LED-PI using 0, 1, and 2 J energy doses) or a combination of factors (LED-PI and Cu-GHK) on fibroblast viability (i.e., alamarBlue reduction), collagen production (i.e., P1CP production and COL1 mRNA expression), and bFGF secretion were also evaluated.
  2. 02LabIn vitro (cells)Efficacy outcome

    In human fibroblasts, LED photoirradiation plus Cu-GHK increased P1CP production compared with LED photoirradiation alone.

    In plain wordsIn cells, red light plus Cu-GHK raised collagen precursor production more than red light alone.

    Peptide
    GHK-Cu
    Outcome
    IncreaseP1CP production
    Study

    humann: not reported in source

    Human fibroblasts (HS68)
    Comparator
    LED-PI alone
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Measurements

    P1CP production increase
    ≈ 30%
    vs LED-PI alone

    Source sentences

    Summary
    The combinative effects of LED-PI and Cu-GHK led to an increase not only in bFGF secretion (approximately 230%) but also in P1CP production (approximately 30%) and COL1 mRNA expression (approximately 70%) compared with LED-PI alone.
    2 context sentences
    Summary · context
    Cell activity/viability, procollagen type I C-peptide (P1CP), and bFGF were evaluated in vitro with human fibroblasts (HS68).
    Summary · context
    The effects of single factors (LED-PI using 0, 1, and 2 J energy doses) or a combination of factors (LED-PI and Cu-GHK) on fibroblast viability (i.e., alamarBlue reduction), collagen production (i.e., P1CP production and COL1 mRNA expression), and bFGF secretion were also evaluated.
  3. 03LabIn vitro (cells)Efficacy outcome

    In human fibroblasts, LED photoirradiation plus Cu-GHK increased COL1 mRNA expression compared with LED photoirradiation alone.

    In plain wordsIn cells, red light plus Cu-GHK raised type I collagen gene activity more than red light alone.

    Peptide
    GHK-Cu
    Outcome
    IncreaseCOL1 mRNA expression
    Study

    humann: not reported in source

    Human fibroblasts (HS68)
    Comparator
    LED-PI alone
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Measurements

    COL1 mRNA expression increase
    ≈ 70%
    vs LED-PI alone

    Source sentences

    Summary
    The combinative effects of LED-PI and Cu-GHK led to an increase not only in bFGF secretion (approximately 230%) but also in P1CP production (approximately 30%) and COL1 mRNA expression (approximately 70%) compared with LED-PI alone.
    2 context sentences
    Summary · context
    Cell activity/viability, procollagen type I C-peptide (P1CP), and bFGF were evaluated in vitro with human fibroblasts (HS68).
    Summary · context
    The effects of single factors (LED-PI using 0, 1, and 2 J energy doses) or a combination of factors (LED-PI and Cu-GHK) on fibroblast viability (i.e., alamarBlue reduction), collagen production (i.e., P1CP production and COL1 mRNA expression), and bFGF secretion were also evaluated.

Studies that did not test the peptide alone4

In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK-Cu.

  1. 04LabNot a test of GHK-Cu aloneIn vitro (cells)Efficacy outcome

    In human fibroblasts, the reduction in cell viability was significantly suppressed with LED photoirradiation (1 J) and Cu-GHK-supplied incubation.

    In plain wordsIn cells, Cu-GHK given with red light helped fibroblasts keep their viability.

    Peptide
    GHK-Cu
    Outcome
    DecreaseFibroblast viability reduction with LED-PI and Cu-GHK
    Study

    humann: not reported in source

    Human fibroblasts (HS68)
    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    Reduction in cell viability was significantly suppressed with LED-PI (1 J) and Cu-GHK-supplied incubation.
    2 context sentences
    Summary · context
    Cell activity/viability, procollagen type I C-peptide (P1CP), and bFGF were evaluated in vitro with human fibroblasts (HS68).
    Summary · context
    The effects of single factors (LED-PI using 0, 1, and 2 J energy doses) or a combination of factors (LED-PI and Cu-GHK) on fibroblast viability (i.e., alamarBlue reduction), collagen production (i.e., P1CP production and COL1 mRNA expression), and bFGF secretion were also evaluated.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  2. 05LabNot a test of GHK-Cu aloneIn vitro (cells)Efficacy outcome

    In human fibroblasts, cell viability was increased 12.5-fold compared with the non-irradiated group (0 J); the abstract does not separate the effect of Cu-GHK from that of LED photoirradiation.

    In plain wordsIn cells, viability was 12.5-fold higher than in cells that received no light; the abstract does not show how much of this came from Cu-GHK.

    Peptide
    GHK-Cu
    Outcome
    IncreaseFibroblast viability fold change
    Study

    humann: not reported in source

    Human fibroblasts (HS68)
    Comparator
    Non-irradiated group (0 J)
    Outcome group
    Wound healing · Skin and wound

    Measurements

    Cell viability increase
    12.5 fold
    vs non-irradiated group (0 J)

    Source sentences

    Summary
    Reduction in cell viability was significantly suppressed with LED-PI (1 J) and Cu-GHK-supplied incubation. Cell viability was increased 12.5-fold compared with the non-irradiated group (0 J).
    2 context sentences
    Summary · context
    Cell activity/viability, procollagen type I C-peptide (P1CP), and bFGF were evaluated in vitro with human fibroblasts (HS68).
    Summary · context
    The effects of single factors (LED-PI using 0, 1, and 2 J energy doses) or a combination of factors (LED-PI and Cu-GHK) on fibroblast viability (i.e., alamarBlue reduction), collagen production (i.e., P1CP production and COL1 mRNA expression), and bFGF secretion were also evaluated.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  3. 06LabNot a test of GHK-Cu aloneIn vitro (cells)Efficacy outcome

    In human fibroblasts, collagen production increased significantly with LED photoirradiation and Cu-GHK incorporation.

    In plain wordsIn cells, collagen production rose significantly with red light plus Cu-GHK.

    Peptide
    GHK-Cu
    Outcome
    IncreaseCollagen production (P1CP)
    Study

    humann: not reported in source

    Human fibroblasts (HS68)
    Outcome group
    Wound healing · Skin and wound

    Measurements

    Collagen production
    197.6 ng/mL
    LED-PI plus Cu-GHK

    Source sentences

    Summary
    Collagen production was also increased significantly with LED-PI and Cu-GHK incorporation (197.6 ng/mL).
    2 context sentences
    Summary · context
    Cell activity/viability, procollagen type I C-peptide (P1CP), and bFGF were evaluated in vitro with human fibroblasts (HS68).
    Summary · context
    The effects of single factors (LED-PI using 0, 1, and 2 J energy doses) or a combination of factors (LED-PI and Cu-GHK) on fibroblast viability (i.e., alamarBlue reduction), collagen production (i.e., P1CP production and COL1 mRNA expression), and bFGF secretion were also evaluated.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

  4. 07LabNot a test of GHK-Cu aloneIn vitro (cells)Activity measurement

    In human fibroblasts, a dose-response effect was observed for LED photoirradiation combined with Cu-GHK.

    In plain wordsIn cells, a dose-response effect was seen for red light combined with Cu-GHK.

    Peptide
    GHK-Cu
    Outcome
    Not applicableDose-response of LED-PI combined with Cu-GHK
    Study

    humann: not reported in source

    Human fibroblasts (HS68)
    Outcome group
    Wound healing · Skin and wound

    Source sentences

    Summary
    A dose-response effect was observed for LED-PI combined with Cu-GHK.
    2 context sentences
    Summary · context
    Cell activity/viability, procollagen type I C-peptide (P1CP), and bFGF were evaluated in vitro with human fibroblasts (HS68).
    Summary · context
    The effects of single factors (LED-PI using 0, 1, and 2 J energy doses) or a combination of factors (LED-PI and Cu-GHK) on fibroblast viability (i.e., alamarBlue reduction), collagen production (i.e., P1CP production and COL1 mRNA expression), and bFGF secretion were also evaluated.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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