Fracture repair: modulation of fracture-callus and mechanical properties by sequential application of IL-6 following PTH 1-34 or PTH 28-48.

Rozen N, Lewinson D, Bick T, Jacob ZC, Stein H, Soudry M

Bone8 May 2007Cited by 35 (Europe PMC)

PMID17599848DOI10.1016/j.bone.2007.04.193PepBankPUB-17599848

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with tibial fractures, PTH 1‑34 alone increased callus volume by 20% at 14 days.
In plain wordsIn rats, PTH increased fracture callus volume versus control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus volume at 14 days
Study
ratn: not reported in source
Tibial fracture
Comparator
Vehicle-treated fractured bones
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · Local injection into fracture hematoma · Days 4, 5 and 6 after fractureAs given in this study (rat).
Measurements
Callus volume increase
20%
PTH 1-34 alone at 14 days
Source sentences
Summary
Post-fracture callus volume as measured 14 days post-fracture was increased significantly only by PTH 1-34 (20%; P<0.01).
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study we employed a novel device developed by us implementing a standardized fracture in rat tibiae.
Summary · context
We investigated the effect of PTH 28-48 or PTH 1-34 alone or in sequence combination with IL-6 together with its soluble receptor (IL-6sR) on fracture repair.
Summary · context
PTH 28-48 or PTH 1-34 was applied locally into the hematoma of fractures on days 4, 5 and 6 and IL-6+ its soluble receptor on days 7, 9, and 11.
Report a problemFND-1759984801
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH 1‑34 alone enlarged callus volume on radiographs at 5 weeks.
In plain wordsIn rats, PTH alone enlarged fracture callus volume versus control on radiographs.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseRadiographic callus volume at 5 weeks
Study
ratn: not reported in source
Tibial fracture
Comparator
Vehicle-treated fractured bones
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · Local injection into fracture hematoma · Days 4, 5 and 6 after fractureAs given in this study (rat).
Source sentences
Summary
X-rays radiography at 5 weeks post-fracture showed enlarged callus volume following treatment by either PTH fragments alone, and complete union following the sequential injection of both PTH fragments and IL-6+IL-6sR, only.
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study we employed a novel device developed by us implementing a standardized fracture in rat tibiae.
Summary · context
We investigated the effect of PTH 28-48 or PTH 1-34 alone or in sequence combination with IL-6 together with its soluble receptor (IL-6sR) on fracture repair.
Summary · context
PTH 28-48 or PTH 1-34 was applied locally into the hematoma of fractures on days 4, 5 and 6 and IL-6+ its soluble receptor on days 7, 9, and 11.
Report a problemFND-1759984803
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH 1‑34 alone did not produce the mechanical resistance increase seen only with the sequential IL-6 plus IL-6sR combination.
In plain wordsIn rats, PTH 1‑34 alone did not produce the repaired bone resistance increase seen with the combination.
Peptide
Teriparatide (PTH 1-34)
Outcome
No significant changeMechanical resistance with PTH 1-34 alone
Study
ratn: not reported in source
Tibial fracture
Comparator
Vehicle-treated fractured bones
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · Local injection into fracture hematoma · Days 4, 5 and 6 after fractureAs given in this study (rat).
Source sentences
Summary
Only the combination of one of the PTH fragments with IL-6+IL-6sR, as measured 6 weeks post-fracture by three point bending, changed dramatically the quality of the regenerating bone as presented by a 300% increase in mechanical resistance when PTH 1-34 was combined and 200% when PTH 28-48 was combi…
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study we employed a novel device developed by us implementing a standardized fracture in rat tibiae.
Summary · context
We investigated the effect of PTH 28-48 or PTH 1-34 alone or in sequence combination with IL-6 together with its soluble receptor (IL-6sR) on fracture repair.
Summary · context
PTH 28-48 or PTH 1-34 was applied locally into the hematoma of fractures on days 4, 5 and 6 and IL-6+ its soluble receptor on days 7, 9, and 11.
Report a problemFND-1759984806
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, PTH 1‑34 alone did not produce complete union at 5 weeks, which occurred only with sequential combination treatment.
In plain wordsIn rats, PTH 1‑34 alone did not produce complete fracture union at 5 weeks.
Peptide
Teriparatide (PTH 1-34)
Outcome
Direction not reportedComplete fracture union with PTH 1-34 alone
Study
ratn: not reported in source
Tibial fracture
Comparator
Vehicle-treated fractured bones
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · Local injection into fracture hematoma · Days 4, 5 and 6 after fractureAs given in this study (rat).
Source sentences
Summary
X-rays radiography at 5 weeks post-fracture showed enlarged callus volume following treatment by either PTH fragments alone, and complete union following the sequential injection of both PTH fragments and IL-6+IL-6sR, only.
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study we employed a novel device developed by us implementing a standardized fracture in rat tibiae.
Summary · context
We investigated the effect of PTH 28-48 or PTH 1-34 alone or in sequence combination with IL-6 together with its soluble receptor (IL-6sR) on fracture repair.
Summary · context
PTH 28-48 or PTH 1-34 was applied locally into the hematoma of fractures on days 4, 5 and 6 and IL-6+ its soluble receptor on days 7, 9, and 11.
Report a problemFND-1759984807

Studies that did not test the peptide alone3

In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Teriparatide (PTH 1-34).

05AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In rats, sequential PTH 1‑34 or PTH 28-48 followed by IL-6 plus IL-6sR increased callus volume by 33%.
In plain wordsIn rats, PTH fragment regimens, including PTH 1‑34, followed by IL-6 plus its soluble receptor increased callus volume versus control.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCallus volume with sequential combination
Study
ratn: not reported in source
Tibial fracture
Comparator
Vehicle-treated fractured bones
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
When one of the PTH fragments and IL-6+IL-6sR were applied sequentially callus volume was increased significantly (33%; P<0.01).
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study we employed a novel device developed by us implementing a standardized fracture in rat tibiae.
Summary · context
We investigated the effect of PTH 28-48 or PTH 1-34 alone or in sequence combination with IL-6 together with its soluble receptor (IL-6sR) on fracture repair.
Summary · context
PTH 28-48 or PTH 1-34 was applied locally into the hematoma of fractures on days 4, 5 and 6 and IL-6+ its soluble receptor on days 7, 9, and 11.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1759984802
06AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In rats, complete union at 5 weeks occurred only with sequential PTH fragments, including PTH 1‑34, followed by IL-6 plus IL-6sR.
In plain wordsIn rats, only PTH fragment regimens followed by IL-6 plus its soluble receptor produced complete fracture union.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseComplete fracture union
Study
ratn: not reported in source
Tibial fracture
Comparator
Vehicle-treated fractured bones
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
X-rays radiography at 5 weeks post-fracture showed enlarged callus volume following treatment by either PTH fragments alone, and complete union following the sequential injection of both PTH fragments and IL-6+IL-6sR, only.
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study we employed a novel device developed by us implementing a standardized fracture in rat tibiae.
Summary · context
We investigated the effect of PTH 28-48 or PTH 1-34 alone or in sequence combination with IL-6 together with its soluble receptor (IL-6sR) on fracture repair.
Summary · context
PTH 28-48 or PTH 1-34 was applied locally into the hematoma of fractures on days 4, 5 and 6 and IL-6+ its soluble receptor on days 7, 9, and 11.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1759984804
07AnimalNot a test of Teriparatide (PTH 1-34) aloneAnimal study (in vivo)Efficacy outcome
In rats, sequential PTH 1‑34 and IL-6 plus IL-6sR increased mechanical resistance by 300% versus vehicle-treated fractured bones.
In plain wordsIn rats, PTH 1‑34 followed by IL-6 plus its soluble receptor increased repaired bone resistance versus vehicle.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseMechanical resistance at 6 weeks
Study
ratn: not reported in source
Tibial fracture
Comparator
Vehicle-treated fractured bones
Outcome group
Bone and joint · Musculoskeletal
Measurements
Mechanical resistance increase
300%
PTH 1-34 combination versus vehicle
Source sentences
Summary
Only the combination of one of the PTH fragments with IL-6+IL-6sR, as measured 6 weeks post-fracture by three point bending, changed dramatically the quality of the regenerating bone as presented by a 300% increase in mechanical resistance when PTH 1-34 was combined and 200% when PTH 28-48 was combi…
3 context sentences(design, population, supporting numbers)
Summary · context
In the present study we employed a novel device developed by us implementing a standardized fracture in rat tibiae.
Summary · context
We investigated the effect of PTH 28-48 or PTH 1-34 alone or in sequence combination with IL-6 together with its soluble receptor (IL-6sR) on fracture repair.
Summary · context
PTH 28-48 or PTH 1-34 was applied locally into the hematoma of fractures on days 4, 5 and 6 and IL-6+ its soluble receptor on days 7, 9, and 11.
In this study, Teriparatide (PTH 1-34) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Teriparatide (PTH 1-34).
Report a problemFND-1759984805

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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