Mechano-growth factor reduces loss of cardiac function in acute myocardial infarction.

Carpenter V, Matthews K, Devlin G, Stuart S, Jensen J, Conaglen J, Jeanplong F, Goldspink P, Yang SY, Goldspink G, Bass J, McMahon C

Heart, lung & circulation19 Jun 2007Cited by 48 (Europe PMC)

PMID17581790DOI10.1016/j.hlc.2007.04.013PepBankPUB-17581790

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

01AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In sheep with induced myocardial infarction, cardiac function improved with the MGF E domain in experiment 1.
In plain wordsIn sheep after a heart attack, treatment with the MGF E domain improved heart function compared with vehicle.
Peptide
MGF / PEG-MGF
Outcome
IncreaseCardiac function in experiment 1
Study
sheepn: not reported in source
Sheep with microsphere-induced myocardial infarction
Comparator
Vehicle
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
In experiment 1, cardiac function improved in sheep treated with the MGF E domain
2 context sentences(design, population, supporting numbers)
Summary · context
Infarcts were induced by injection of microspheres.
Summary · context
In experiment 1, sheep were treated with vehicle, 200 nM each of mature IGF-I, MGF E domain, or full-length MGF.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-1758179001
02AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In sheep with induced myocardial infarction, the MGF E domain preserved cardiac function in experiment 2.
In plain wordsIn sheep after a heart attack, the MGF E domain kept heart function better than vehicle.
Peptide
MGF / PEG-MGF
Outcome
IncreaseCardiac function in experiment 2
Study
sheepn: not reported in source
Sheep with microsphere-induced myocardial infarction
Comparator
Vehicle
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
in experiment 2, MGF E domain preserved cardiac function
2 context sentences(design, population, supporting numbers)
Summary · context
Infarcts were induced by injection of microspheres.
Summary · context
In experiment 2, sheep were treated with vehicle or 200 nM of MGF E domain alone.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-1758179002
03AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Efficacy outcome
In sheep with induced myocardial infarction, the MGF E domain gave 35% less compromised cardiac muscle than controls.
In plain wordsIn sheep after a heart attack, the MGF E domain left less damaged heart muscle than in controls.
Peptide
MGF / PEG-MGF
Outcome
DecreaseCompromised cardiac muscle area
Study
sheepn: not reported in source
Sheep with microsphere-induced myocardial infarction
Comparator
Vehicle
Outcome group
Heart function · Cardiovascular
Measurements
Less compromised cardiac muscle
35%
MGF E domain versus controls
Source sentences
Summary
In experiment 1, cardiac function improved in sheep treated with the MGF E domain, while in experiment 2, MGF E domain preserved cardiac function and there was 35% less compromised cardiac muscle than controls.
2 context sentences(design, population, supporting numbers)
Summary · context
Infarcts were induced by injection of microspheres.
Summary · context
In experiment 2, sheep were treated with vehicle or 200 nM of MGF E domain alone.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-1758179003
04AnimalNot a test of MGF / PEG-MGF aloneAnimal study (in vivo)Mechanism
In sheep with induced myocardial infarction, cleaved caspase 3 immunostaining was absent in hearts treated with the MGF E domain.
In plain wordsIn sheep after a heart attack, a cell-death marker was absent in hearts treated with the MGF E domain.
Peptide
MGF / PEG-MGF
Outcome
DecreaseCleaved caspase 3 immunostaining
Study
sheepn: not reported in source
Sheep with microsphere-induced myocardial infarction
Comparator
Vehicle
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
Furthermore, immunostaining of cleaved caspase 3 was absent in MGF E domain-treated hearts, suggesting that MGF E domain reduced infarct expansion.
2 context sentences(design, population, supporting numbers)
Summary · context
Infarcts were induced by injection of microspheres.
Summary · context
Immunohistochemistry was used to assess the abundance of pAkt(T308) and cleaved caspase 3.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-1758179004

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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