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Study · In vitro (cell-free) · 2007

4 results

Redox chemistry of copper-amyloid-beta: the generation of hydroxyl radical in the presence of ascorbate is linked to redox-potentials and aggregation state.

Guilloreau L, Combalbert S, Sournia-Saquet A, Mazarguil H, Faller P

Chembiochem : a European journal of chemical biology1 Jul 2007Cited by 204 (Europe PMC)

PMID17577900 (opens in a new tab)DOI10.1002/cbic.200700111 (opens in a new tab)PepBankPUB-17577900
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Activity measurement

    In a cell-free assay, the Cu-GHK complex produced more hydroxyl radical than the copper-Abeta complex, which produced more than Cu-DAHK.

    In plain wordsIn lab tests, the copper complex of GHK made more hydroxyl radical than the copper complex of beta-amyloid.

    Peptide
    GHK-Cu
    Outcome
    IncreaseHydroxyl radical (HO.) production
    Study

    n: not reported in source

    Comparator
    Cu-Abeta
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cu-Abeta produced more HO(.) than the complex of copper with Asp-Ala-His-Lys (Cu-DAHK), but less than with Gly-His-Lys (Cu-GHK).
    1 context sentence
    Summary · context
    To get a better understanding of these reactions, we measured the production of HO(.) and the redox potential of Cu-Abeta.
  2. 02LabIn vitro (cell-free)Activity measurement

    In cyclic voltammetry, the Cu-GHK complex had a higher reduction potential than Cu-Abeta and Cu-DAHK.

    In plain wordsIn lab tests, the copper complex of GHK had a higher reduction potential than the copper complexes of beta-amyloid and DAHK.

    Peptide
    GHK-Cu
    Outcome
    IncreaseReduction potential of copper complex
    Study

    n: not reported in source

    Comparator
    Cu-Abeta
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cyclic voltammetry revealed that the order for reduction potential is Cu-GHK>Cu-Abeta>Cu-DAHK, but for the oxidation potential the order is reversed.
    1 context sentence
    Summary · context
    To get a better understanding of these reactions, we measured the production of HO(.) and the redox potential of Cu-Abeta.
  3. 03LabIn vitro (cell-free)Activity measurement

    In cyclic voltammetry, the Cu-GHK complex had a lower oxidation potential than Cu-Abeta and Cu-DAHK (the order was the reverse of the reduction potential order).

    In plain wordsIn lab tests, the copper complex of GHK had a lower oxidation potential than the copper complexes of beta-amyloid and DAHK.

    Peptide
    GHK-Cu
    Outcome
    DecreaseOxidation potential of copper complex
    Study

    n: not reported in source

    Comparator
    Cu-Abeta
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cyclic voltammetry revealed that the order for reduction potential is Cu-GHK>Cu-Abeta>Cu-DAHK, but for the oxidation potential the order is reversed.
    1 context sentence
    Summary · context
    To get a better understanding of these reactions, we measured the production of HO(.) and the redox potential of Cu-Abeta.

Studies that did not test the peptide alone1

In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK-Cu.

  1. 04LabNot a test of GHK-Cu aloneIn vitro (cell-free)Mechanism

    Across the copper complexes tested, including Cu-GHK, easier copper redox cycling correlated with higher hydroxyl radical production.

    In plain wordsIn lab tests, copper complexes that cycled between redox states more easily made more hydroxyl radical.

    Peptide
    GHK-Cu
    Outcome
    Not applicableLink between copper redox cycling and HO. production
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Thus, easier copper redox cycling correlated to higher HO(.) production.
    1 context sentence
    Summary · context
    To get a better understanding of these reactions, we measured the production of HO(.) and the redox potential of Cu-Abeta.

    In this study, GHK-Cu was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK-Cu.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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