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Study · Animal study (in vivo) · mouse and rat · 2007

5 results

Thymosin alpha1 as a chemopreventive agent in lung and breast cancer.

Moody TW

Annals of the New York Academy of Sciences13 Jun 2007Cited by 27 (Europe PMC)

PMID17567944 (opens in a new tab)DOI10.1196/annals.1415.040 (opens in a new tab)PepBankPUB-17567944
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In A/J mice given a carcinogen, daily subcutaneous thymosin alpha‑1 at 0.4 mg/kg reduced lung adenoma number by 15-45%.

    In plain wordsIn mice exposed to a lung carcinogen, daily thymosin alpha‑1 injections cut the number of lung tumours by 15 to 45%.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseLung adenoma number
    Study

    mousen: not reported in source

    urethane-induced lung adenoma in A/J mice
    Outcome group
    Tumor growth · Cancer
    Studied dose
    0.4 mg/kg · subcutaneousAs given in this study (mouse).

    Measurements

    reduction in lung adenoma number
    15 to 45%
    A/J mice, 0.4 mg/kg s.c.

    Source sentences

    Summary
    The lung adenoma number was reduced by 15-45% if animals were daily treated subcutaneously (s.c.) with Talpha1 (0.4 mg/kg).
    1 context sentence
    Summary · context
    Lung adenomas developed in A/J mice injected with carcinogens, such as urethane.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Fisher rats with N-methylurea-induced mammary cancer, daily thymosin alpha‑1 injection significantly increased survival.

    In plain wordsIn rats with induced breast cancer, daily thymosin alpha‑1 injections increased survival.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSurvival in NMU-induced mammary cancer
    Study

    ratn: not reported in source

    N-methylurea-induced estrogen receptor-dependent mammary cancer in Fisher rats
    Outcome group
    Mortality · Cancer
    Studied dose
    Dose not stated · injectionAs given in this study (rat).

    Source sentences

    Summary
    The rat survival was significantly increased by the daily injection of Talpha1.
    1 context sentence
    Summary · context
    In the Fisher rat, an animal model of mammary cancer that is estrogen receptor dependent, tumors were initiated by the injection of N-methylurea (NMU).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In SV40T antigen transgenic mice with spontaneous mammary cancer, daily thymosin alpha‑1 injection increased survival.

    In plain wordsIn mice that develop breast cancer on their own, daily thymosin alpha‑1 injections increased survival.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseSurvival in SV40T mammary cancer model
    Study

    mousen: not reported in source

    SV40T antigen transgenic female mouse with spontaneous mammary cancer
    Outcome group
    Mortality · Cancer
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    In the SV40T antigen mouse, a transgenic female mouse that spontaneously gets mammary cancer in an estrogen receptor-independent manner, survival was increased
    1 context sentence
    Summary · context
    In the SV40T antigen mouse, a transgenic female mouse that spontaneously gets mammary cancer in an estrogen receptor-independent manner, survival was increased and tumor burden was significantly decreased by daily injection of Talpha1.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In SV40T antigen transgenic mice with spontaneous mammary cancer, daily thymosin alpha‑1 injection significantly decreased tumor burden.

    In plain wordsIn mice that develop breast cancer on their own, daily thymosin alpha‑1 injections reduced tumour burden.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseTumor burden in SV40T mammary cancer model
    Study

    mousen: not reported in source

    SV40T antigen transgenic female mouse with spontaneous mammary cancer
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    In the SV40T antigen mouse, a transgenic female mouse that spontaneously gets mammary cancer in an estrogen receptor-independent manner, survival was increased and tumor burden was significantly decreased by daily injection of Talpha1.
  5. 05LabIn vitro (cells)Efficacy outcome

    In mouse lung cell lines, thymosin alpha‑1 at 1 microM directly inhibited cell growth.

    In plain wordsIn cells from mouse lung, thymosin alpha‑1 slowed cell growth.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseGrowth of mouse lung cell lines
    Study

    mousen: not reported in source

    mouse lung cell lines
    Outcome group
    Tumor growth · Cancer
    Studied dose
    1 microMAs given in this study (mouse).

    Source sentences

    Summary
    Talpha1 (1 microM) directly inhibited the growth of mouse lung cell lines.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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