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Study · In vitro (cells) · mouse · 2007

9 results

Signaling pathways leading to the activation of IKK and MAPK by thymosin alpha1.

Peng X, Zhang P, Wang X, Chan J, Zhu M, Jiang M, Tuthill C, Wan Y, Dragoi AM, Chu WM

Annals of the New York Academy of Sciences13 Jun 2007Cited by 16 (Europe PMC)

PMID17567943 (opens in a new tab)DOI10.1196/annals.1415.025 (opens in a new tab)PepBankPUB-17567943
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In murine bone marrow-derived macrophages, Talpha1 induced production of IL-6 through IKK and MAPK pathways.

    In plain wordsIn mouse immune cells grown in the lab, Talpha1 triggered production of IL-6.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseIL-6 production
    Study

    mousen: not reported in source

    murine bone marrow-derived macrophages
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that Talpha1 induces the production of interleukin-6 (IL-6), IL-10, and IL-12 in murine bone marrow-derived macrophages (BMDMs) through IKK and MAPK pathways.
  2. 02LabIn vitro (cells)Mechanism

    In murine bone marrow-derived macrophages, Talpha1 induced production of IL-10 through IKK and MAPK pathways.

    In plain wordsIn mouse immune cells grown in the lab, Talpha1 triggered production of IL-10.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseIL-10 production
    Study

    mousen: not reported in source

    murine bone marrow-derived macrophages
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that Talpha1 induces the production of interleukin-6 (IL-6), IL-10, and IL-12 in murine bone marrow-derived macrophages (BMDMs) through IKK and MAPK pathways.
  3. 03LabIn vitro (cells)Mechanism

    In murine bone marrow-derived macrophages, Talpha1 induced production of IL-12 through IKK and MAPK pathways.

    In plain wordsIn mouse immune cells grown in the lab, Talpha1 triggered production of IL-12.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseIL-12 production
    Study

    mousen: not reported in source

    murine bone marrow-derived macrophages
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We found that Talpha1 induces the production of interleukin-6 (IL-6), IL-10, and IL-12 in murine bone marrow-derived macrophages (BMDMs) through IKK and MAPK pathways.
  4. 04LabIn vitro (cells)Mechanism

    In murine macrophages, Talpha1 triggered activation of AP-1.

    In plain wordsIn mouse immune cells grown in the lab, Talpha1 switched on the AP-1 signal protein.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAP-1 activation
    Study

    mousen: not reported in source

    murine bone marrow-derived macrophages
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Talpha1 triggers the activation of AP-1 and the phosphorylation of JNK and p38.
  5. 05LabIn vitro (cells)Mechanism

    In murine macrophages, Talpha1 triggered phosphorylation of JNK.

    In plain wordsIn mouse immune cells grown in the lab, Talpha1 switched on the JNK signal protein.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseJNK phosphorylation
    Study

    mousen: not reported in source

    murine bone marrow-derived macrophages
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Talpha1 triggers the activation of AP-1 and the phosphorylation of JNK and p38.
  6. 06LabIn vitro (cells)Mechanism

    In murine macrophages, Talpha1 triggered phosphorylation of p38.

    In plain wordsIn mouse immune cells grown in the lab, Talpha1 switched on the p38 signal protein.

    Peptide
    Thymosin alpha-1
    Outcome
    Increasep38 phosphorylation
    Study

    mousen: not reported in source

    murine bone marrow-derived macrophages
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Talpha1 triggers the activation of AP-1 and the phosphorylation of JNK and p38.

Studies that did not test the peptide alone3

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

  1. 07LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Mechanism

    In murine macrophages, inhibition of p38 impaired the IL-6 production that Talpha1 induced.

    In plain wordsIn mouse immune cells grown in the lab, blocking p38 reduced the IL-6 that Talpha1 triggered.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseIL-6 production with p38 inhibition
    Study

    mousen: not reported in source

    murine bone marrow-derived macrophages
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    Inhibition of p38 impairs IL-6 production in response to Talpha1.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  2. 08LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Mechanism

    In the Talpha1-induced system, TRAF6 was involved in JNK activation, and IRAK4 was involved in activation of IKK and PKCzeta.

    In plain wordsIn mouse immune cells grown in the lab, TRAF6 and IRAK4 took part in the signals that Talpha1 triggered.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableJNK and IKK activation pathway (TRAF6, IRAK4)
    Study

    mousen: not reported in source

    murine bone marrow-derived macrophages
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    Further, TRAF6 is involved in the activation of JNK and IRAK4 is involved for the activation of IKK and PKCzeta in a Talpha1-induced system.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

  3. 09LabNot a test of Thymosin alpha-1 aloneIn vitro (cells)Mechanism

    In murine macrophages, loss of IRAK4 largely blocked IL-6 induction by Talpha1.

    In plain wordsIn mouse immune cells grown in the lab, losing IRAK4 largely stopped the IL-6 response to Talpha1.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseIL-6 induction after IRAK4 loss
    Study

    mousen: not reported in source

    murine bone marrow-derived macrophages
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    Loss of IRAK4 largely blocked induction of IL-6.

    In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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