Neonatal oxytocin treatment modulates oxytocin receptor, atrial natriuretic peptide, nitric oxide synthase and estrogen receptor mRNAs expression in rat heart.

Pournajafi-Nazarloo H, Perry A, Partoo L, Papademeteriou E, Azizi F, Carter CS, Cushing BS

Peptides6 May 2007Cited by 21 (Europe PMC)

PMID17537544PMCIDPMC2044561DOI10.1016/j.peptides.2007.04.022PepBankPUB-17537544

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In neonatal rats, oxytocin treatment increased heart oxytocin receptor mRNA expression on day 1 in both males and females.
In plain wordsIn newborn rats, oxytocin treatment raised oxytocin receptor activity in the heart on day 1 in both sexes.
Peptide
Oxytocin
Outcome
IncreaseHeart OTR mRNA expression on day 1
Study
ratn: not reported in source
Neonatal rats, heart tissue
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
7 µg · intraperitonealAs given in this study (rat).
Source sentences
Summary
OT treatment significantly increased heart OTR, ANP and eNOS mRNAs expression on D1 in both males and females
2 context sentences(design, population, supporting numbers)
Summary · context
On the first day of postnatal life, female and male rats were randomly assigned to receive one of the following treatments: (a) 50microl i.p. injection of 7microg OT; (b) 0.7microg of OT antagonist (OTA); or (c) isotonic saline (SAL).
Summary · context
Hearts were collected either on postnatal day 1 or day 21 (D1 or D21) and the mRNAs expression of OTR, ANP, inducible NOS (iNOS), eNOS, ERalpha and estrogen receptor beta (ERbeta) were compared by age, treatment, and sex utilizing real time PCR.
Report a problemFND-1753754401
02AnimalAnimal study (in vivo)Mechanism
In neonatal rats, oxytocin treatment increased heart atrial natriuretic peptide mRNA expression on day 1 in both males and females.
In plain wordsIn newborn rats, oxytocin treatment raised heart ANP gene activity on day 1 in both sexes.
Peptide
Oxytocin
Outcome
IncreaseHeart ANP mRNA expression on day 1
Study
ratn: not reported in source
Neonatal rats, heart tissue
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
7 µg · intraperitonealAs given in this study (rat).
Source sentences
Summary
OT treatment significantly increased heart OTR, ANP and eNOS mRNAs expression on D1 in both males and females
2 context sentences(design, population, supporting numbers)
Summary · context
On the first day of postnatal life, female and male rats were randomly assigned to receive one of the following treatments: (a) 50microl i.p. injection of 7microg OT; (b) 0.7microg of OT antagonist (OTA); or (c) isotonic saline (SAL).
Summary · context
Hearts were collected either on postnatal day 1 or day 21 (D1 or D21) and the mRNAs expression of OTR, ANP, inducible NOS (iNOS), eNOS, ERalpha and estrogen receptor beta (ERbeta) were compared by age, treatment, and sex utilizing real time PCR.
Report a problemFND-1753754402
03AnimalAnimal study (in vivo)Mechanism
In neonatal rats, oxytocin treatment increased heart eNOS mRNA expression on day 1 in both males and females.
In plain wordsIn newborn rats, oxytocin treatment raised heart eNOS gene activity on day 1 in both sexes.
Peptide
Oxytocin
Outcome
IncreaseHeart eNOS mRNA expression on day 1
Study
ratn: not reported in source
Neonatal rats, heart tissue
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
7 µg · intraperitonealAs given in this study (rat).
Source sentences
Summary
OT treatment significantly increased heart OTR, ANP and eNOS mRNAs expression on D1 in both males and females
2 context sentences(design, population, supporting numbers)
Summary · context
On the first day of postnatal life, female and male rats were randomly assigned to receive one of the following treatments: (a) 50microl i.p. injection of 7microg OT; (b) 0.7microg of OT antagonist (OTA); or (c) isotonic saline (SAL).
Summary · context
Hearts were collected either on postnatal day 1 or day 21 (D1 or D21) and the mRNAs expression of OTR, ANP, inducible NOS (iNOS), eNOS, ERalpha and estrogen receptor beta (ERbeta) were compared by age, treatment, and sex utilizing real time PCR.
Report a problemFND-1753754403
04AnimalAnimal study (in vivo)Mechanism
In neonatal rats, oxytocin treatment increased heart estrogen receptor alpha mRNA expression on day 1 in females only.
In plain wordsIn newborn rats, oxytocin treatment raised heart estrogen receptor alpha gene activity on day 1 in females only.
Peptide
Oxytocin
Outcome
IncreaseHeart ERalpha mRNA expression on day 1
Study
ratn: not reported in source
Neonatal rats, heart tissue
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
7 µg · intraperitonealAs given in this study (rat).
Source sentences
Summary
OT treatment significantly increased heart OTR, ANP and eNOS mRNAs expression on D1 in both males and females, ERalpha increased only in females.
2 context sentences(design, population, supporting numbers)
Summary · context
On the first day of postnatal life, female and male rats were randomly assigned to receive one of the following treatments: (a) 50microl i.p. injection of 7microg OT; (b) 0.7microg of OT antagonist (OTA); or (c) isotonic saline (SAL).
Summary · context
Hearts were collected either on postnatal day 1 or day 21 (D1 or D21) and the mRNAs expression of OTR, ANP, inducible NOS (iNOS), eNOS, ERalpha and estrogen receptor beta (ERbeta) were compared by age, treatment, and sex utilizing real time PCR.
Report a problemFND-1753754404
05AnimalAnimal study (in vivo)Mechanism
In rats treated as neonates with oxytocin or an oxytocin antagonist, no significant treatment effects on heart mRNA expression were seen on day 21.
In plain wordsIn rats given oxytocin or an oxytocin blocker as newborns, no treatment effects on heart gene activity were seen at day 21.
Peptide
Oxytocin
Outcome
No significant changeHeart mRNA expression on day 21
Study
ratn: not reported in source
Neonatal rats, heart tissue
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Studied dose
7 µg · intraperitonealAs given in this study (rat).
Source sentences
Summary
there were no significant treatment effects observed in D21 animals.
2 context sentences(design, population, supporting numbers)
Summary · context
On the first day of postnatal life, female and male rats were randomly assigned to receive one of the following treatments: (a) 50microl i.p. injection of 7microg OT; (b) 0.7microg of OT antagonist (OTA); or (c) isotonic saline (SAL).
Summary · context
Hearts were collected either on postnatal day 1 or day 21 (D1 or D21) and the mRNAs expression of OTR, ANP, inducible NOS (iNOS), eNOS, ERalpha and estrogen receptor beta (ERbeta) were compared by age, treatment, and sex utilizing real time PCR.
Report a problemFND-1753754405

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

06AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In neonatal rats, an oxytocin receptor antagonist decreased basal heart ANP mRNA expression on day 1 in both sexes.
In plain wordsIn newborn rats, a drug that blocks oxytocin receptors lowered basal heart ANP gene activity on day 1 in both sexes.
Peptide
Oxytocin
Outcome
DecreaseBasal heart ANP mRNA expression on day 1 with oxytocin antagonist
Study
ratn: not reported in source
Neonatal rats, heart tissue
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
OTA treatment significantly decreased basal ANP and eNOS mRNAs expression on D1 in both sexes.
2 context sentences(design, population, supporting numbers)
Summary · context
On the first day of postnatal life, female and male rats were randomly assigned to receive one of the following treatments: (a) 50microl i.p. injection of 7microg OT; (b) 0.7microg of OT antagonist (OTA); or (c) isotonic saline (SAL).
Summary · context
Hearts were collected either on postnatal day 1 or day 21 (D1 or D21) and the mRNAs expression of OTR, ANP, inducible NOS (iNOS), eNOS, ERalpha and estrogen receptor beta (ERbeta) were compared by age, treatment, and sex utilizing real time PCR.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1753754406
07AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In neonatal rats, an oxytocin receptor antagonist decreased basal heart eNOS mRNA expression on day 1 in both sexes.
In plain wordsIn newborn rats, a drug that blocks oxytocin receptors lowered basal heart eNOS gene activity on day 1 in both sexes.
Peptide
Oxytocin
Outcome
DecreaseBasal heart eNOS mRNA expression on day 1 with oxytocin antagonist
Study
ratn: not reported in source
Neonatal rats, heart tissue
Comparator
Saline
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
OTA treatment significantly decreased basal ANP and eNOS mRNAs expression on D1 in both sexes.
2 context sentences(design, population, supporting numbers)
Summary · context
On the first day of postnatal life, female and male rats were randomly assigned to receive one of the following treatments: (a) 50microl i.p. injection of 7microg OT; (b) 0.7microg of OT antagonist (OTA); or (c) isotonic saline (SAL).
Summary · context
Hearts were collected either on postnatal day 1 or day 21 (D1 or D21) and the mRNAs expression of OTR, ANP, inducible NOS (iNOS), eNOS, ERalpha and estrogen receptor beta (ERbeta) were compared by age, treatment, and sex utilizing real time PCR.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1753754407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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