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Study · In vitro (cells) · 2007

9 results

Thymosin-alpha1 modulates dendritic cell differentiation and functional maturation from human peripheral blood CD14+ monocytes.

Yao Q, Doan LX, Zhang R, Bharadwaj U, Li M, Chen C

Immunology letters15 May 2007Cited by 31 (Europe PMC)

PMID17532057 (opens in a new tab)PMCIDPMC1986709 (opens in a new tab)DOI10.1016/j.imlet.2007.04.007 (opens in a new tab)PepBankPUB-17532057
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human monocyte-derived immature dendritic cells, thymosin alpha‑1 significantly upregulated CD40.

    In plain wordsIn human immune cells grown in the lab, thymosin alpha‑1 raised the surface marker CD40.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD40 expression on immature DCs
    Study

    humann: not reported in source

    monocyte-derived dendritic cells from human peripheral blood CD14+ monocytes
    Comparator
    non-Talpha1-treated cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the presence of Talpha1, iDC surface markers CD40, CD80, MHC class I and class II molecules were significantly upregulated as measured by flow cytemotry analysis.
    1 context sentence
    Summary · context
    Human peripheral blood CD14(+) monocytes were purified by using a magnetic separation column and cultured with GM-CSF and IL-4 to differentiate into immature DCs (iDCs).
  2. 02LabIn vitro (cells)Activity measurement

    In human monocyte-derived immature dendritic cells, thymosin alpha‑1 significantly upregulated CD80.

    In plain wordsIn human immune cells grown in the lab, thymosin alpha‑1 raised the surface marker CD80.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD80 expression on immature DCs
    Study

    humann: not reported in source

    monocyte-derived dendritic cells from human peripheral blood CD14+ monocytes
    Comparator
    non-Talpha1-treated cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the presence of Talpha1, iDC surface markers CD40, CD80, MHC class I and class II molecules were significantly upregulated as measured by flow cytemotry analysis.
    1 context sentence
    Summary · context
    Human peripheral blood CD14(+) monocytes were purified by using a magnetic separation column and cultured with GM-CSF and IL-4 to differentiate into immature DCs (iDCs).
  3. 03LabIn vitro (cells)Activity measurement

    In human monocyte-derived immature dendritic cells, thymosin alpha‑1 significantly upregulated MHC class I molecules.

    In plain wordsIn human immune cells grown in the lab, thymosin alpha‑1 raised MHC class I molecules on the cell surface.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseMHC class I expression on immature DCs
    Study

    humann: not reported in source

    monocyte-derived dendritic cells from human peripheral blood CD14+ monocytes
    Comparator
    non-Talpha1-treated cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the presence of Talpha1, iDC surface markers CD40, CD80, MHC class I and class II molecules were significantly upregulated as measured by flow cytemotry analysis.
    1 context sentence
    Summary · context
    Human peripheral blood CD14(+) monocytes were purified by using a magnetic separation column and cultured with GM-CSF and IL-4 to differentiate into immature DCs (iDCs).
  4. 04LabIn vitro (cells)Activity measurement

    In human monocyte-derived immature dendritic cells, thymosin alpha‑1 significantly upregulated MHC class II molecules.

    In plain wordsIn human immune cells grown in the lab, thymosin alpha‑1 raised MHC class II molecules on the cell surface.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseMHC class II expression on immature DCs
    Study

    humann: not reported in source

    monocyte-derived dendritic cells from human peripheral blood CD14+ monocytes
    Comparator
    non-Talpha1-treated cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the presence of Talpha1, iDC surface markers CD40, CD80, MHC class I and class II molecules were significantly upregulated as measured by flow cytemotry analysis.
    1 context sentence
    Summary · context
    Human peripheral blood CD14(+) monocytes were purified by using a magnetic separation column and cultured with GM-CSF and IL-4 to differentiate into immature DCs (iDCs).
  5. 05LabIn vitro (cells)Activity measurement

    In human monocyte-derived immature dendritic cells, thymosin alpha‑1 reduced FITC-dextran antigen uptake by approximately 30%.

    In plain wordsIn human immune cells grown in the lab, thymosin alpha‑1 lowered antigen uptake by about 30% compared with untreated cells.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseAntigen uptake by immature DCs
    Study

    humann: not reported in source

    monocyte-derived dendritic cells from human peripheral blood CD14+ monocytes
    Comparator
    non-Talpha1-treated cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    reduction in antigen uptake
    ≈ 30%
    Talpha1-treated iDCs

    Source sentences

    Summary
    There was an approximately 30% reduction in antigen (FITC-conjugated dextran)-uptake by Talpha1-treated iDCs as compared with non-Talpha1-treated iDCs.
    1 context sentence
    Summary · context
    Human peripheral blood CD14(+) monocytes were purified by using a magnetic separation column and cultured with GM-CSF and IL-4 to differentiate into immature DCs (iDCs).
  6. 06LabIn vitro (cells)Activity measurement

    Thymosin alpha‑1-treated mature dendritic cells showed increased stimulation of allogeneic CD3+ T-cell proliferation in a mixed-lymphocyte reaction.

    In plain wordsIn lab tests, mature immune cells treated with thymosin alpha‑1 stimulated T-cell growth more than untreated cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAllogeneic CD3+ T-cell proliferation stimulated by mature DCs
    Study

    humann: not reported in source

    monocyte-derived dendritic cells from human peripheral blood CD14+ monocytes
    Comparator
    non-Talpha1-treated cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, Talpha1-treated matured DCs (mDCs) showed an increased stimulation of allogeneic CD3(+) T-cell proliferation as measured by a mixed-lymphocyte reaction assay.
    1 context sentence
    Summary · context
    Human peripheral blood CD14(+) monocytes were purified by using a magnetic separation column and cultured with GM-CSF and IL-4 to differentiate into immature DCs (iDCs).
  7. 07LabIn vitro (cells)Activity measurement

    Thymosin alpha‑1-treated mature dendritic cells increased the production of several Th1- and Th2-type cytokines.

    In plain wordsIn lab tests, mature immune cells treated with thymosin alpha‑1 made more of several immune signalling proteins than untreated cells.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseTh1- and Th2-type cytokine production by mature DCs
    Study

    humann: not reported in source

    monocyte-derived dendritic cells from human peripheral blood CD14+ monocytes
    Comparator
    non-Talpha1-treated cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Talpha1-treated mDCs also increased the production of several Th1- and Th2-type cytokines as measured by a Bio-Plex cytokine assay.
    1 context sentence
    Summary · context
    Human peripheral blood CD14(+) monocytes were purified by using a magnetic separation column and cultured with GM-CSF and IL-4 to differentiate into immature DCs (iDCs).
  8. 08LabIn vitro (cells)Mechanism

    In immature dendritic cells, thymosin alpha‑1 caused rapid activation of p38 MAPK.

    In plain wordsIn human immune cells grown in the lab, thymosin alpha‑1 quickly switched on the signalling protein p38 MAPK.

    Peptide
    Thymosin alpha-1
    Outcome
    Increasep38 MAPK activation in immature DCs
    Study

    humann: not reported in source

    monocyte-derived dendritic cells from human peripheral blood CD14+ monocytes
    Comparator
    non-Talpha1-treated cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, rapid activation of p38 MAPK and NFkappaB was seen in Talpha1-treated iDCs as measured by a Bio-Plex phosphoprotein assay.
    1 context sentence
    Summary · context
    Human peripheral blood CD14(+) monocytes were purified by using a magnetic separation column and cultured with GM-CSF and IL-4 to differentiate into immature DCs (iDCs).
  9. 09LabIn vitro (cells)Mechanism

    In immature dendritic cells, thymosin alpha‑1 caused rapid activation of NFkappaB.

    In plain wordsIn human immune cells grown in the lab, thymosin alpha‑1 quickly switched on the signalling protein NFkappaB.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseNFkappaB activation in immature DCs
    Study

    humann: not reported in source

    monocyte-derived dendritic cells from human peripheral blood CD14+ monocytes
    Comparator
    non-Talpha1-treated cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, rapid activation of p38 MAPK and NFkappaB was seen in Talpha1-treated iDCs as measured by a Bio-Plex phosphoprotein assay.
    1 context sentence
    Summary · context
    Human peripheral blood CD14(+) monocytes were purified by using a magnetic separation column and cultured with GM-CSF and IL-4 to differentiate into immature DCs (iDCs).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

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