In vivo treatment with a nonapeptide thymic hormone, facteur thymique serique (FTS), ameliorates chronic colitis induced by dextran sulphate sodium in mice.

Sun X, Yamada H, Yoshihara K, Awaya A, Yoshikai Y

International immunopharmacology28 Mar 2007Cited by 5 (Europe PMC)

PMID17499195DOI10.1016/j.intimp.2007.02.014PepBankPUB-17499195

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice with acute DSS colitis, FTS did not affect survival.
In plain wordsIn mice with acute colitis, FTS did not change survival compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeAcute colitis survival
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Mortality · Gastrointestinal
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
FTS did not affect the course of acute colitis induced by DSS as assessed by survival rate, clinical activity of diseases, extent of tissue damage of colons.
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919501
02AnimalAnimal study (in vivo)Efficacy outcome
In mice with acute DSS colitis, FTS did not affect clinical disease activity.
In plain wordsIn mice with acute colitis, FTS did not change disease activity compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeAcute colitis clinical activity
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
FTS did not affect the course of acute colitis induced by DSS as assessed by survival rate, clinical activity of diseases, extent of tissue damage of colons.
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919502
03AnimalAnimal study (in vivo)Efficacy outcome
In mice with acute DSS colitis, FTS did not affect colon tissue damage.
In plain wordsIn mice with acute colitis, FTS did not change colon damage compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeAcute colitis tissue damage
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
FTS did not affect the course of acute colitis induced by DSS as assessed by survival rate, clinical activity of diseases, extent of tissue damage of colons.
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919503
04AnimalAnimal study (in vivo)Efficacy outcome
In mice with chronic DSS colitis, FTS reduced lethality.
In plain wordsIn mice with chronic colitis, FTS reduced deaths compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseChronic colitis lethality
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Mortality · Gastrointestinal
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
On the other hand, FTS significantly ameliorated chronic colitis induced by multiple cycles of DSS as reflected by lower lethality, weight loss, clinical scores and histological scores.
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919504
05AnimalAnimal study (in vivo)Efficacy outcome
In mice with chronic DSS colitis, FTS reduced weight loss.
In plain wordsIn mice with chronic colitis, FTS reduced weight loss compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseChronic colitis weight loss
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Body weight · Metabolic and weight
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
On the other hand, FTS significantly ameliorated chronic colitis induced by multiple cycles of DSS as reflected by lower lethality, weight loss, clinical scores and histological scores.
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919505
06AnimalAnimal study (in vivo)Efficacy outcome
In mice with chronic DSS colitis, FTS reduced clinical scores.
In plain wordsIn mice with chronic colitis, FTS reduced clinical scores compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseChronic colitis clinical score
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
On the other hand, FTS significantly ameliorated chronic colitis induced by multiple cycles of DSS as reflected by lower lethality, weight loss, clinical scores and histological scores.
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919506
07AnimalAnimal study (in vivo)Efficacy outcome
In mice with chronic DSS colitis, FTS reduced histological scores.
In plain wordsIn mice with chronic colitis, FTS reduced tissue damage scores compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseChronic colitis histological score
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
On the other hand, FTS significantly ameliorated chronic colitis induced by multiple cycles of DSS as reflected by lower lethality, weight loss, clinical scores and histological scores.
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919507
08AnimalAnimal study (in vivo)Mechanism
In DSS-treated mice, FTS reduced unstimulated colonic LP cell IFN-gamma production.
In plain wordsIn mice, FTS reduced IFN-gamma production by unstimulated colon immune cells compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseLP cell IFN-gamma
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
The levels of interferon (IFN)-gamma, interleukin 1(IL-1)-beta, and IL-12p40 in the culture supernatants of lamina propria (LP) cells of colon without any stimulation and IFN-gamma by T cells in the LP T cells under T cell receptor (TCR) triggering were reduced in FTS-treated mice
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919508
09AnimalAnimal study (in vivo)Mechanism
In DSS-treated mice, FTS reduced unstimulated colonic LP cell IL-1-beta production.
In plain wordsIn mice, FTS reduced IL-1-beta production by colon immune cells compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseLP cell IL-1-beta
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
The levels of interferon (IFN)-gamma, interleukin 1(IL-1)-beta, and IL-12p40 in the culture supernatants of lamina propria (LP) cells of colon without any stimulation and IFN-gamma by T cells in the LP T cells under T cell receptor (TCR) triggering were reduced in FTS-treated mice
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919509
10AnimalAnimal study (in vivo)Mechanism
In DSS-treated mice, FTS reduced unstimulated colonic LP cell IL-12p40 production.
In plain wordsIn mice, FTS reduced IL-12p40 production by colon immune cells compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseLP cell IL-12p40
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
The levels of interferon (IFN)-gamma, interleukin 1(IL-1)-beta, and IL-12p40 in the culture supernatants of lamina propria (LP) cells of colon without any stimulation and IFN-gamma by T cells in the LP T cells under T cell receptor (TCR) triggering were reduced in FTS-treated mice
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919510
11AnimalAnimal study (in vivo)Mechanism
In DSS-treated mice, FTS reduced IFN-gamma production by TCR-triggered LP T cells.
In plain wordsIn mice, FTS reduced IFN-gamma production by stimulated intestinal T cells compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseTCR-triggered LP T cell IFN-gamma
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
The levels of interferon (IFN)-gamma, interleukin 1(IL-1)-beta, and IL-12p40 in the culture supernatants of lamina propria (LP) cells of colon without any stimulation and IFN-gamma by T cells in the LP T cells under T cell receptor (TCR) triggering were reduced in FTS-treated mice
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919511
12AnimalAnimal study (in vivo)Mechanism
In DSS-treated mice, FTS increased IL-10 production by LP cells.
In plain wordsIn mice, FTS increased IL-10 production by intestinal immune cells compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseLP cell IL-10
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Immune response · Immune and inflammation
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
whereas the levels of IL-10 by LP cells and LPT cells were higher in FTS-treated mice.
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919512
13AnimalAnimal study (in vivo)Mechanism
In DSS-treated mice, FTS increased IL-10 production by LP T cells.
In plain wordsIn mice, FTS increased IL-10 production by intestinal T cells compared with DSS alone.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseLP T cell IL-10
Study
mousen: not reported in source
DSS-induced colitis in BALB/c mice
Comparator
DSS without FTS
Outcome group
Immune response · Immune and inflammation
Studied dose
1 mug/mouse/day · subcutaneousAs given in this study (mouse).
Source sentences
Summary
whereas the levels of IL-10 by LP cells and LPT cells were higher in FTS-treated mice.
2 context sentences(design, population, supporting numbers)
Summary · context
Here we investigated the effect of FTS on dextran sulphate sodium (DSS)-induced colitis.
Summary · context
BALB/c mice were subcutaneously treated with 1 mug/mouse/day of FTS daily.
Report a problemFND-1749919513

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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