In baboons with endometriosis, ganirelix produced a greater negative relative change in peritoneal lesion surface area than controls.
In plain wordsIn baboons with endometriosis, ganirelix reduced lesion surface area more than controls.
- Peptide
- Ganirelix
- Outcome
- DecreaseRelative change in lesion surface area
- Study
baboonn: not reported in source
induced endometriosis- Comparator
- placebo controls
- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
- Studied dose
- 125 microg/day · 30 daysAs given in this study (baboon).
Source sentences
Baboons treated with rosiglitazone or ganirelix had a greater negative relative change in surface area of peritoneal endometriotic lesions than controls.
3 context sentences(design, population, supporting numbers)
Endometriosis was induced using intrapelvic injection of eutopic menstrual endometrium in 12 female baboons with a normal pelvis that had undergone at least one menstrual cycle since the time of captivity.
The 12 baboons were randomized into three groups and treated from the day after the staging laparoscopy for a total duration of 30 days.
They received phosphate-buffered saline tablets (n = 4, placebo control; placebo tablets once a day by mouth for 30 days), GnRH-antagonists (n = 4, active control; ganirelix acetate 125 microg/day for 30 days), or rosiglitazone (n = 4, test drug, 2 mg by mouth each day for 30 days).