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Study · In vitro (cells) · 2007

4 results

Ghrelin and GHRP-6 enhance electrical and secretory activity in GC somatotropes.

Dominguez B, Felix R, Monjaraz E

Biochemical and biophysical research communications20 Apr 2007Cited by 15 (Europe PMC)

PMID17481583 (opens in a new tab)DOI10.1016/j.bbrc.2007.04.085 (opens in a new tab)PepBankPUB-17481583
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In GC somatotropes, chronic GHRP‑6 treatment increased spontaneous action potential firing frequency.

    In plain wordsIn cells, chronic GHRP‑6 treatment increased the frequency of spontaneous electrical signals.

    Peptide
    GHRP-6
    Outcome
    IncreaseSpontaneous action potential firing frequency
    Study

    n: not reported in source

    Somatotrope GC cell line
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · 96hAs given in this study.

    Source sentences

    Summary
    In the current report, we show that the chronic (96h) treatment with ghrelin and GHRP-6 increases the firing frequency of SAP in the somatotrope GC cell line.
  2. 02LabIn vitro (cells)Mechanism

    In GC somatotropes, chronic GHRP‑6 treatment increased whole-cell inward current density.

    In plain wordsIn cells, chronic GHRP‑6 treatment increased inward electrical current density.

    Peptide
    GHRP-6
    Outcome
    IncreaseWhole-cell inward current density
    Study

    n: not reported in source

    Somatotrope GC cell line
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated · 96hAs given in this study.

    Source sentences

    Summary
    This action is associated with a significant increase in whole-cell inward current density.
    1 context sentence
    Summary · context
    In the current report, we show that the chronic (96h) treatment with ghrelin and GHRP-6 increases the firing frequency of SAP in the somatotrope GC cell line.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 03LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In GC cells, long-term sodium current antagonism decreased GHRP‑6-induced GH release.

    In plain wordsIn cells, sodium current blockers reduced growth hormone release induced by GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    DecreaseGHRP-6-induced GH release with sodium current antagonists
    Study

    n: not reported in source

    Somatotrope GC cell line
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In addition, long-term application of Na(+) or L-type Ca(2+) current antagonists decreases GHRP-6-induced release of GH, indicating that the ionic currents that give rise to SAP play important roles for hormone secretion in the GC cells.
    1 context sentence
    Summary · context
    In the current report, we show that the chronic (96h) treatment with ghrelin and GHRP-6 increases the firing frequency of SAP in the somatotrope GC cell line.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 04LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In GC cells, long-term L-type calcium current antagonism decreased GHRP‑6-induced GH release.

    In plain wordsIn cells, L-type calcium current blockers reduced growth hormone release induced by GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    DecreaseGHRP-6-induced GH release with calcium current antagonists
    Study

    n: not reported in source

    Somatotrope GC cell line
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In addition, long-term application of Na(+) or L-type Ca(2+) current antagonists decreases GHRP-6-induced release of GH, indicating that the ionic currents that give rise to SAP play important roles for hormone secretion in the GC cells.
    1 context sentence
    Summary · context
    In the current report, we show that the chronic (96h) treatment with ghrelin and GHRP-6 increases the firing frequency of SAP in the somatotrope GC cell line.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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