Cerebrolysin enhances functional recovery following focal cerebral infarction in rats.

Ren J, Sietsma D, Qiu S, Moessler H, Finklestein SP

Restorative neurology and neuroscience1 Jan 2007Cited by 43 (Europe PMC)

PMID17473393DOI10.3233/rnn-2007-00349PepBankPUB-17473393

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats after focal cerebral infarction, Cerebrolysin enhanced sensorimotor recovery, especially at the 2.5 ml/kg dose.
In plain wordsIn rats after stroke, Cerebrolysin improved sensorimotor recovery, especially at the 2.5 ml/kg dose.
Peptide
Cerebrolysin
Outcome
IncreaseSensorimotor recovery
Study
ratn: not reported in source
Middle cerebral artery occlusion
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
1.0, 2.5, or 5.0 ml/kg · intraperitoneal · 21 daysAs given in this study (rat).
Source sentences
Summary
Enhancement of sensorimotor recovery, as assessed by forelimb and hindlimb placing and body swing tests, was seen with Cerebrolysin treatment, especially at the 2.5 ml/kg dose.
1 context sentence(design, population, supporting numbers)
Summary · context
Cerebrolysin (1.0, 2.5, or 5.0 ml/kg) was administered once daily intraperitoneally for 21 days, starting 24 hours after focal cerebral infarction (stroke) due to middle cerebral artery occlusion in mature rats.
Report a problemFND-1747339301
02AnimalAnimal study (in vivo)Efficacy outcome
In rats after stroke, Cerebrolysin enhanced recovery when treatment began at 24 hours.
In plain wordsIn rats after stroke, Cerebrolysin improved recovery when treatment began at 24 hours.
Peptide
Cerebrolysin
Outcome
IncreaseRecovery with treatment starting at 24 hours
Study
ratn: not reported in source
Middle cerebral artery occlusion
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
2.5 ml/kg · intraperitoneal · 21 daysAs given in this study (rat).
Source sentences
Summary
At this dose, enhanced recovery was found when Cerebrolysin treatment was begun at 24 or 48 (but not 72 hours) after stroke onset.
2 context sentences(design, population, supporting numbers)
Summary · context
Enhancement of sensorimotor recovery, as assessed by forelimb and hindlimb placing and body swing tests, was seen with Cerebrolysin treatment, especially at the 2.5 ml/kg dose.
Summary · context
Cerebrolysin (1.0, 2.5, or 5.0 ml/kg) was administered once daily intraperitoneally for 21 days, starting 24 hours after focal cerebral infarction (stroke) due to middle cerebral artery occlusion in mature rats.
Report a problemFND-1747339302
03AnimalAnimal study (in vivo)Efficacy outcome
In rats after stroke, Cerebrolysin enhanced recovery when treatment began at 48 hours.
In plain wordsIn rats after stroke, Cerebrolysin improved recovery when treatment began at 48 hours.
Peptide
Cerebrolysin
Outcome
IncreaseRecovery with treatment starting at 48 hours
Study
ratn: not reported in source
Middle cerebral artery occlusion
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
2.5 ml/kg · intraperitoneal · 21 daysAs given in this study (rat).
Source sentences
Summary
At this dose, enhanced recovery was found when Cerebrolysin treatment was begun at 24 or 48 (but not 72 hours) after stroke onset.
2 context sentences(design, population, supporting numbers)
Summary · context
Enhancement of sensorimotor recovery, as assessed by forelimb and hindlimb placing and body swing tests, was seen with Cerebrolysin treatment, especially at the 2.5 ml/kg dose.
Summary · context
Cerebrolysin (1.0, 2.5, or 5.0 ml/kg) was administered once daily intraperitoneally for 21 days, starting 24 hours after focal cerebral infarction (stroke) due to middle cerebral artery occlusion in mature rats.
Report a problemFND-1747339303
04AnimalAnimal study (in vivo)Efficacy outcome
In rats after stroke, Cerebrolysin did not enhance recovery when treatment began at 72 hours.
In plain wordsIn rats after stroke, Cerebrolysin did not improve recovery when treatment began at 72 hours.
Peptide
Cerebrolysin
Outcome
No significant changeRecovery with treatment starting at 72 hours
Study
ratn: not reported in source
Middle cerebral artery occlusion
Outcome group
Exercise and physical function · Nervous system and cognition
Studied dose
2.5 ml/kg · intraperitoneal · 21 daysAs given in this study (rat).
Source sentences
Summary
At this dose, enhanced recovery was found when Cerebrolysin treatment was begun at 24 or 48 (but not 72 hours) after stroke onset.
2 context sentences(design, population, supporting numbers)
Summary · context
Enhancement of sensorimotor recovery, as assessed by forelimb and hindlimb placing and body swing tests, was seen with Cerebrolysin treatment, especially at the 2.5 ml/kg dose.
Summary · context
Cerebrolysin (1.0, 2.5, or 5.0 ml/kg) was administered once daily intraperitoneally for 21 days, starting 24 hours after focal cerebral infarction (stroke) due to middle cerebral artery occlusion in mature rats.
Report a problemFND-1747339304
05AnimalAnimal study (in vivo)Efficacy outcome
In rats after focal cerebral infarction, Cerebrolysin had no effect on body weight.
In plain wordsIn rats after stroke, Cerebrolysin did not change body weight.
Peptide
Cerebrolysin
Outcome
No significant changeBody weight
Study
ratn: not reported in source
Middle cerebral artery occlusion
Outcome group
Body weight · Metabolic and weight
Studied dose
1.0, 2.5, or 5.0 ml/kg · intraperitoneal · 21 daysAs given in this study (rat).
Source sentences
Summary
There were no effects on body weight or infarct volume when Cerebrolysin was administered in this manner.
1 context sentence(design, population, supporting numbers)
Summary · context
Cerebrolysin (1.0, 2.5, or 5.0 ml/kg) was administered once daily intraperitoneally for 21 days, starting 24 hours after focal cerebral infarction (stroke) due to middle cerebral artery occlusion in mature rats.
Report a problemFND-1747339305
06AnimalAnimal study (in vivo)Efficacy outcome
In rats after focal cerebral infarction, Cerebrolysin had no effect on infarct volume.
In plain wordsIn rats after stroke, Cerebrolysin did not change the size of the infarct.
Peptide
Cerebrolysin
Outcome
No significant changeInfarct volume
Study
ratn: not reported in source
Middle cerebral artery occlusion
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1.0, 2.5, or 5.0 ml/kg · intraperitoneal · 21 daysAs given in this study (rat).
Source sentences
Summary
There were no effects on body weight or infarct volume when Cerebrolysin was administered in this manner.
1 context sentence(design, population, supporting numbers)
Summary · context
Cerebrolysin (1.0, 2.5, or 5.0 ml/kg) was administered once daily intraperitoneally for 21 days, starting 24 hours after focal cerebral infarction (stroke) due to middle cerebral artery occlusion in mature rats.
Report a problemFND-1747339306

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

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