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Study · In vitro (cells) · 2007

5 results

NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis.

Busciglio J, Pelsman A, Helguera P, Ashur-Fabian O, Pinhasov A, Brenneman DE, Gozes I

Current pharmaceutical design1 Jan 2007Cited by 39 (Europe PMC)

PMID17430172 (opens in a new tab)DOI10.2174/138161207780618957 (opens in a new tab)PepBankPUB-17430172
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human cortical neurons exposed to H2O2, NAP significantly increased survival.

    In plain wordsIn cells exposed to H2O2, NAP increased neuron survival.

    Peptide
    Davunetide
    Outcome
    IncreaseSurvival after H2O2
    Study

    humann: not reported in source

    Human cortical neuron cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Femtomolar concentrationsAs given in this study (human).

    Source sentences

    Summary
    Addition of ADNF-9 or NAP at femtomolar concentrations resulted in significant increases in survival of normal neurons treated with H2O2.
    1 context sentence
    Summary · context
    Here, the neuroprotective activity of ADNF-9 and NAP was tested in two human models of neuronal degeneration in culture mediated by oxidative stress: normal human cortical neurons treated with H2O2 and Down's syndrome (DS) cortical neurons.
  2. 02LabIn vitro (cells)Efficacy outcome

    In human cortical neurons, NAP showed neuroprotective efficacy comparable to s-PBN at 100 microM.

    In plain wordsIn cells, NAP showed protection comparable to s-PBN.

    Peptide
    Davunetide
    Outcome
    Not applicableNeuroprotective efficacy versus s-PBN
    Study

    humann: not reported in source

    Human cortical neuron cultures
    Comparator
    s-PBN at 100 microM
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Femtomolar concentrationsAs given in this study (human).

    Source sentences

    Summary
    Femtomolar concentrations of ADNF-9 or NAP exhibited a similar neuroprotective efficacy, comparable to the antioxidant N-tert-butyl-2-sulpho-phenylnitrone at 100 microM (s-PBN).
    1 context sentence
    Summary · context
    Here, the neuroprotective activity of ADNF-9 and NAP was tested in two human models of neuronal degeneration in culture mediated by oxidative stress: normal human cortical neurons treated with H2O2 and Down's syndrome (DS) cortical neurons.
  3. 03LabIn vitro (cells)Efficacy outcome

    In Down's syndrome cortical neurons, NAP significantly increased neuronal survival.

    In plain wordsIn cultured Down's syndrome neurons, NAP increased neuron survival.

    Peptide
    Davunetide
    Outcome
    IncreaseDown syndrome neuron survival
    Study

    humann: not reported in source

    Down's syndrome cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Femtomolar concentrationsAs given in this study (human).

    Source sentences

    Summary
    Treatment of DS cortical neurons with ADNF-9 or NAP resulted in a significant increase in neuronal survival as well as reduction of degenerative morphological changes.
    2 context sentences
    Summary · context
    Here, the neuroprotective activity of ADNF-9 and NAP was tested in two human models of neuronal degeneration in culture mediated by oxidative stress: normal human cortical neurons treated with H2O2 and Down's syndrome (DS) cortical neurons.
    Summary · context
    Femtomolar concentrations of ADNF-9 or NAP exhibited a similar neuroprotective efficacy, comparable to the antioxidant N-tert-butyl-2-sulpho-phenylnitrone at 100 microM (s-PBN).
  4. 04LabIn vitro (cells)Efficacy outcome

    In Down's syndrome cortical neurons, NAP reduced degenerative morphological changes.

    In plain wordsIn cultured Down's syndrome neurons, NAP reduced degenerative changes.

    Peptide
    Davunetide
    Outcome
    DecreaseDegenerative morphology
    Study

    humann: not reported in source

    Down's syndrome cortical neurons
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Femtomolar concentrationsAs given in this study (human).

    Source sentences

    Summary
    Treatment of DS cortical neurons with ADNF-9 or NAP resulted in a significant increase in neuronal survival as well as reduction of degenerative morphological changes.
    2 context sentences
    Summary · context
    Here, the neuroprotective activity of ADNF-9 and NAP was tested in two human models of neuronal degeneration in culture mediated by oxidative stress: normal human cortical neurons treated with H2O2 and Down's syndrome (DS) cortical neurons.
    Summary · context
    Femtomolar concentrations of ADNF-9 or NAP exhibited a similar neuroprotective efficacy, comparable to the antioxidant N-tert-butyl-2-sulpho-phenylnitrone at 100 microM (s-PBN).
  5. 05LabIn vitro (cells)Efficacy outcome

    In human cortical neuron cultures, femtomolar NAP showed neuroprotective efficacy similar to ADNF-9.

    In plain wordsIn cells, NAP showed protection similar to ADNF-9.

    Peptide
    Davunetide
    Outcome
    Not applicableNeuroprotective efficacy versus ADNF-9
    Study

    humann: not reported in source

    Human cortical neuron cultures
    Comparator
    ADNF-9
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Femtomolar concentrationsAs given in this study (human).

    Source sentences

    Summary
    Femtomolar concentrations of ADNF-9 or NAP exhibited a similar neuroprotective efficacy, comparable to the antioxidant N-tert-butyl-2-sulpho-phenylnitrone at 100 microM (s-PBN).
    1 context sentence
    Summary · context
    Here, the neuroprotective activity of ADNF-9 and NAP was tested in two human models of neuronal degeneration in culture mediated by oxidative stress: normal human cortical neurons treated with H2O2 and Down's syndrome (DS) cortical neurons.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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