Synthetic adrenocorticotropic hormone stimulation tests in healthy neonatal foals.

Hart KA, Ferguson DC, Heusner GL, Barton MH

Journal of veterinary internal medicine1 Mar 2007Cited by 16 (Europe PMC)

PMID17427394DOI10.1892/0891-6640(2007)21[314:sahsti]2.0.co;2PepBankPUB-17427394

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone11

In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cosyntropin.

01AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In neonatal foals, 1 microg cosyntropin did not significantly increase cortisol.
In plain wordsIn foals, 1 microg cosyntropin did not significantly increase cortisol.
Peptide
Cosyntropin
Outcome
No significant changeCortisol response to 1 microg
Study
horsen: not reported in source
Healthy neonatal foals
Comparator
Baseline
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
Serum cortisol concentrations did not significantly increase after administration of 1 microg of cosyntropin.
3 context sentences(design, population, supporting numbers)
Summary · context
14 healthy neonatal foals, 3-4 days of age.
Summary · context
A randomized cross-over model was used in which cosyntropin (1, 10, 100, or 250 microg) was administered intravenously on days 3 and 4 of life.
Summary · context
Blood samples were collected before and 30, 60, 90, 120, and 150 minutes after administration of cosyntropin for determination of serum cortisol concentration.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1742739401
02AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In neonatal foals, cortisol peaked 30 minutes after 10 microg cosyntropin.
In plain wordsIn foals, cortisol peaked 30 minutes after 10 microg cosyntropin.
Peptide
Cosyntropin
Outcome
Not applicableTime to peak cortisol at 10 microg
Study
horsen: not reported in source
Healthy neonatal foals
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
Cortisol concentration peaked 30 minutes after administration of 10 microg of cosyntropin and 90 minutes after 100 and 250 microg of cosyntropin.
3 context sentences(design, population, supporting numbers)
Summary · context
14 healthy neonatal foals, 3-4 days of age.
Summary · context
A randomized cross-over model was used in which cosyntropin (1, 10, 100, or 250 microg) was administered intravenously on days 3 and 4 of life.
Summary · context
Blood samples were collected before and 30, 60, 90, 120, and 150 minutes after administration of cosyntropin for determination of serum cortisol concentration.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1742739402
03AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In neonatal foals, cortisol peaked 90 minutes after 100 microg cosyntropin.
In plain wordsIn foals, cortisol peaked 90 minutes after 100 microg cosyntropin.
Peptide
Cosyntropin
Outcome
Not applicableTime to peak cortisol at 100 microg
Study
horsen: not reported in source
Healthy neonatal foals
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
Cortisol concentration peaked 30 minutes after administration of 10 microg of cosyntropin and 90 minutes after 100 and 250 microg of cosyntropin.
3 context sentences(design, population, supporting numbers)
Summary · context
14 healthy neonatal foals, 3-4 days of age.
Summary · context
A randomized cross-over model was used in which cosyntropin (1, 10, 100, or 250 microg) was administered intravenously on days 3 and 4 of life.
Summary · context
Blood samples were collected before and 30, 60, 90, 120, and 150 minutes after administration of cosyntropin for determination of serum cortisol concentration.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1742739403
04AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In neonatal foals, cortisol peaked 90 minutes after 250 microg cosyntropin.
In plain wordsIn foals, cortisol peaked 90 minutes after 250 microg cosyntropin.
Peptide
Cosyntropin
Outcome
Not applicableTime to peak cortisol at 250 microg
Study
horsen: not reported in source
Healthy neonatal foals
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
Cortisol concentration peaked 30 minutes after administration of 10 microg of cosyntropin and 90 minutes after 100 and 250 microg of cosyntropin.
3 context sentences(design, population, supporting numbers)
Summary · context
14 healthy neonatal foals, 3-4 days of age.
Summary · context
A randomized cross-over model was used in which cosyntropin (1, 10, 100, or 250 microg) was administered intravenously on days 3 and 4 of life.
Summary · context
Blood samples were collected before and 30, 60, 90, 120, and 150 minutes after administration of cosyntropin for determination of serum cortisol concentration.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1742739404
05AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In neonatal foals, cosyntropin dose had no relationship with cortisol at 30 minutes.
In plain wordsIn foals, cosyntropin dose had no relationship with cortisol at 30 minutes.
Peptide
Cosyntropin
Outcome
No significant changeDose relationship at 30 minutes
Study
horsen: not reported in source
Healthy neonatal foals
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
There was no relationship between cosyntropin dose and serum cortisol concentration at 30 minutes.
3 context sentences(design, population, supporting numbers)
Summary · context
14 healthy neonatal foals, 3-4 days of age.
Summary · context
A randomized cross-over model was used in which cosyntropin (1, 10, 100, or 250 microg) was administered intravenously on days 3 and 4 of life.
Summary · context
Blood samples were collected before and 30, 60, 90, 120, and 150 minutes after administration of cosyntropin for determination of serum cortisol concentration.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1742739405
06AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In neonatal foals, 100 microg cosyntropin induced significantly greater cortisol at 90 minutes than 10 microg.
In plain wordsIn foals, 100 microg cosyntropin produced more cortisol at 90 minutes than 10 microg.
Peptide
Cosyntropin
Outcome
IncreaseCortisol at 90 minutes after 100 microg
Study
horsen: not reported in source
Healthy neonatal foals
Comparator
10 microg cosyntropin
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
Compared with the 10-microg dose, 100 and 250 microg of cosyntropin induced significantly greater cortisol concentrations at 90 minutes, at which point the 10-microg cosyntropin-dose cortisol values were indistinguishable from baseline.
3 context sentences(design, population, supporting numbers)
Summary · context
14 healthy neonatal foals, 3-4 days of age.
Summary · context
A randomized cross-over model was used in which cosyntropin (1, 10, 100, or 250 microg) was administered intravenously on days 3 and 4 of life.
Summary · context
Blood samples were collected before and 30, 60, 90, 120, and 150 minutes after administration of cosyntropin for determination of serum cortisol concentration.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1742739406
07AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In neonatal foals, 250 microg cosyntropin induced significantly greater cortisol at 90 minutes than 10 microg.
In plain wordsIn foals, 250 microg cosyntropin produced more cortisol at 90 minutes than 10 microg.
Peptide
Cosyntropin
Outcome
IncreaseCortisol at 90 minutes after 250 microg
Study
horsen: not reported in source
Healthy neonatal foals
Comparator
10 microg cosyntropin
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
Compared with the 10-microg dose, 100 and 250 microg of cosyntropin induced significantly greater cortisol concentrations at 90 minutes, at which point the 10-microg cosyntropin-dose cortisol values were indistinguishable from baseline.
3 context sentences(design, population, supporting numbers)
Summary · context
14 healthy neonatal foals, 3-4 days of age.
Summary · context
A randomized cross-over model was used in which cosyntropin (1, 10, 100, or 250 microg) was administered intravenously on days 3 and 4 of life.
Summary · context
Blood samples were collected before and 30, 60, 90, 120, and 150 minutes after administration of cosyntropin for determination of serum cortisol concentration.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1742739407
08AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In neonatal foals, cortisol 90 minutes after 10 microg cosyntropin was indistinguishable from baseline.
In plain wordsIn foals, cortisol 90 minutes after 10 microg cosyntropin did not differ from baseline.
Peptide
Cosyntropin
Outcome
No significant changeCortisol at 90 minutes after 10 microg
Study
horsen: not reported in source
Healthy neonatal foals
Comparator
Baseline
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
Compared with the 10-microg dose, 100 and 250 microg of cosyntropin induced significantly greater cortisol concentrations at 90 minutes, at which point the 10-microg cosyntropin-dose cortisol values were indistinguishable from baseline.
3 context sentences(design, population, supporting numbers)
Summary · context
14 healthy neonatal foals, 3-4 days of age.
Summary · context
A randomized cross-over model was used in which cosyntropin (1, 10, 100, or 250 microg) was administered intravenously on days 3 and 4 of life.
Summary · context
Blood samples were collected before and 30, 60, 90, 120, and 150 minutes after administration of cosyntropin for determination of serum cortisol concentration.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1742739408
09AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In neonatal foals, cortisol area under the curve did not differ significantly between 100 and 250 microg cosyntropin.
In plain wordsIn foals, total cortisol responses did not differ significantly between 100 and 250 microg cosyntropin.
Peptide
Cosyntropin
Outcome
No significant changeCortisol area under curve
Study
horsen: not reported in source
Healthy neonatal foals
Comparator
250 microg cosyntropin
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
There was no significant difference in the area under the cortisol concentration curve between the 100- and 250-microg doses.
3 context sentences(design, population, supporting numbers)
Summary · context
14 healthy neonatal foals, 3-4 days of age.
Summary · context
A randomized cross-over model was used in which cosyntropin (1, 10, 100, or 250 microg) was administered intravenously on days 3 and 4 of life.
Summary · context
Blood samples were collected before and 30, 60, 90, 120, and 150 minutes after administration of cosyntropin for determination of serum cortisol concentration.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1742739409
10AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In neonatal foals, testing day did not affect peak cortisol after cosyntropin.
In plain wordsIn foals, testing day did not affect peak cortisol after cosyntropin.
Peptide
Cosyntropin
Outcome
No significant changeTesting day effect on peak cortisol
Study
horsen: not reported in source
Healthy neonatal foals
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
No effect of day of testing or foal weight on peak cortisol concentration was detected.
3 context sentences(design, population, supporting numbers)
Summary · context
14 healthy neonatal foals, 3-4 days of age.
Summary · context
A randomized cross-over model was used in which cosyntropin (1, 10, 100, or 250 microg) was administered intravenously on days 3 and 4 of life.
Summary · context
Blood samples were collected before and 30, 60, 90, 120, and 150 minutes after administration of cosyntropin for determination of serum cortisol concentration.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1742739410
11AnimalNot a test of Cosyntropin aloneAnimal study (in vivo)Activity measurement
In neonatal foals, weight did not affect peak cortisol after cosyntropin.
In plain wordsIn foals, weight did not affect peak cortisol after cosyntropin.
Peptide
Cosyntropin
Outcome
No significant changeWeight effect on peak cortisol
Study
horsen: not reported in source
Healthy neonatal foals
Outcome group
Adrenal Function · Endocrine and hormones
Source sentences
Summary
No effect of day of testing or foal weight on peak cortisol concentration was detected.
3 context sentences(design, population, supporting numbers)
Summary · context
14 healthy neonatal foals, 3-4 days of age.
Summary · context
A randomized cross-over model was used in which cosyntropin (1, 10, 100, or 250 microg) was administered intravenously on days 3 and 4 of life.
Summary · context
Blood samples were collected before and 30, 60, 90, 120, and 150 minutes after administration of cosyntropin for determination of serum cortisol concentration.
In this study, Cosyntropin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cosyntropin.
Report a problemFND-1742739411

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

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Terms as the source lists them.

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MeSH terms

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