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Study · Not a test of the peptide alone · 2007

2 results

Social approach behaviors in oxytocin knockout mice: comparison of two independent lines tested in different laboratory environments.

Crawley JN, Chen T, Puri A, Washburn R, Sullivan TL, Hill JM, Young NB, Nadler JJ, Moy SS, Young LJ, Caldwell HK, Young WS

Neuropeptides8 Apr 2007Cited by 183 (Europe PMC)

PMID17420046 (opens in a new tab)DOI10.1016/j.npep.2007.02.002 (opens in a new tab)PepBankPUB-17420046
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In oxytocin knockout mice of two independent lines, sociability toward a stranger mouse was normal compared with wild-type littermates.

    In plain wordsIn mice lacking oxytocin, interest in a stranger mouse was normal compared with normal littermates.

    Peptide
    Oxytocin
    Outcome
    No significant changeSociability in oxytocin knockout mice
    Study

    mousen: not reported in source

    Oxytocin knockout mice (NIMH and Baylor/Emory lines)
    Comparator
    Wild-type littermate controls
    Outcome group
    Social behavior and cognition · Nervous system and cognition

    Source sentences

    Summary
    Normal sociability, measured as time spent with a novel stranger mouse as compared to time spent with a novel object, was seen in both the NIMH and the Baylor/Emory lines of oxytocin null mutants, heterozygotes, and wild-type littermate controls.
    1 context sentence
    Summary · context
    Two lines of oxytocin knockout mice were tested, the National Institute of Mental Health line in Bethesda, and the Baylor/Emory line at the University of North Carolina in Chapel Hill.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In oxytocin knockout mice of two independent lines, preference for social novelty was normal compared with wild-type littermates, with minor exceptions.

    In plain wordsIn mice lacking oxytocin, preference for a new mouse over a familiar one was normal compared with normal littermates, with minor exceptions.

    Peptide
    Oxytocin
    Outcome
    No significant changePreference for social novelty in oxytocin knockout mice
    Study

    mousen: not reported in source

    Oxytocin knockout mice (NIMH and Baylor/Emory lines)
    Comparator
    Wild-type littermate controls
    Outcome group
    Social behavior and cognition · Nervous system and cognition

    Source sentences

    Summary
    Normal preference for social novelty, measured as time spent with a second novel stranger as compared to time spent with a more familiar mouse, was seen in both the NIMH and the Baylor/Emory lines of oxytocin null mutants, heterozygotes, and wild-type littermate controls, with minor exceptions.
    1 context sentence
    Summary · context
    Two lines of oxytocin knockout mice were tested, the National Institute of Mental Health line in Bethesda, and the Baylor/Emory line at the University of North Carolina in Chapel Hill.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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