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Study · Animal study (in vivo) · rat · 2007

5 results

Melanocortinergic activation by melanotan II inhibits feeding and increases uncoupling protein 1 messenger ribonucleic acid in the developing rat.

Glavas MM, Joachim SE, Draper SJ, Smith MS, Grove KL

Endocrinology5 Apr 2007Cited by 29 (Europe PMC)

PMID17412803 (opens in a new tab)DOI10.1210/en.2007-0184 (opens in a new tab)PepBankPUB-17412803
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rat pups, MTII induced hypothalamic c-Fos activation.

    In plain wordsIn rat pups, Melanotan II switched on a brain-activity marker in the hypothalamus.

    Peptide
    Melanotan II
    Outcome
    IncreaseHypothalamic c-Fos activation
    Study

    ratn: not reported in source

    Rat pups
    Comparator
    Saline
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    3 mg/kg body weight · intraperitoneal · P5 to P6, P10-P11, or P15-P16As given in this study (rat).

    Source sentences

    Summary
    MTII induced hypothalamic c-Fos activation
    1 context sentence
    Summary · context
    Rat pups were injected ip with MTII (3 mg/kg body weight) or saline on postnatal day (P) 5 to P6, P10-P11, or P15-P16 at 1700 and 0900 h and then killed at 1300 h.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rat pups, MTII attenuated body weight gain.

    In plain wordsIn rat pups, Melanotan II reduced weight gain.

    Peptide
    Melanotan II
    Outcome
    DecreaseBody weight gain
    Study

    ratn: not reported in source

    Rat pups
    Comparator
    Saline
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    3 mg/kg body weight · intraperitoneal · P5 to P6, P10-P11, or P15-P16As given in this study (rat).

    Source sentences

    Summary
    as well as attenuating body weight gain in rat pups.
    1 context sentence
    Summary · context
    Rat pups were injected ip with MTII (3 mg/kg body weight) or saline on postnatal day (P) 5 to P6, P10-P11, or P15-P16 at 1700 and 0900 h and then killed at 1300 h.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rat pups, MTII significantly decreased stomach weight at all ages, indicating decreased food intake.

    In plain wordsIn rat pups, Melanotan II lowered stomach weight, which points to less eating.

    Peptide
    Melanotan II
    Outcome
    DecreaseStomach weight (marker of food intake)
    Study

    ratn: not reported in source

    Rat pups
    Comparator
    Saline
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    3 mg/kg body weight · intraperitoneal · P5 to P6, P10-P11, or P15-P16As given in this study (rat).

    Source sentences

    Summary
    Stomach weight was significantly decreased
    2 context sentences
    Summary · context
    indicating decreased food intake and increased energy expenditure, respectively.
    Summary · context
    Rat pups were injected ip with MTII (3 mg/kg body weight) or saline on postnatal day (P) 5 to P6, P10-P11, or P15-P16 at 1700 and 0900 h and then killed at 1300 h.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rat pups, MTII increased brown adipose tissue uncoupling protein 1 mRNA at all ages, indicating increased energy expenditure.

    In plain wordsIn rat pups, Melanotan II raised a brown fat heat-producing gene signal, which points to higher energy use.

    Peptide
    Melanotan II
    Outcome
    IncreaseBrown adipose tissue uncoupling protein 1 mRNA
    Study

    ratn: not reported in source

    Rat pups
    Comparator
    Saline
    Outcome group
    Energy expenditure and thermogenesis · Metabolic and weight
    Studied dose
    3 mg/kg body weight · intraperitoneal · P5 to P6, P10-P11, or P15-P16As given in this study (rat).

    Source sentences

    Summary
    and uncoupling protein 1 mRNA was increased at all ages, indicating decreased food intake and increased energy expenditure, respectively.
    1 context sentence
    Summary · context
    Rat pups were injected ip with MTII (3 mg/kg body weight) or saline on postnatal day (P) 5 to P6, P10-P11, or P15-P16 at 1700 and 0900 h and then killed at 1300 h.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rat pups, twice daily MTII had no effect on neuropeptide Y mRNA in any hypothalamic region.

    In plain wordsIn rat pups, Melanotan II did not change the hypothalamic appetite peptide NPY gene signal.

    Peptide
    Melanotan II
    Outcome
    No significant changeHypothalamic NPY mRNA
    Study

    ratn: not reported in source

    Rat pups
    Comparator
    Saline
    Outcome group
    Appetite and food intake · Nervous system and cognition
    Studied dose
    3 mg/kg body weight · intraperitoneal · Twice daily P5-P10 or P10-P15As given in this study (rat).

    Source sentences

    Summary
    However, MTII had no effect on NPY mRNA levels in any hypothalamic region.
    2 context sentences
    Summary · context
    In addition, we assessed central c-Fos activation 90 min after MTII administration and hypothalamic NPY mRNA after twice daily MTII administration from P5-P10 or P10-P15.
    Summary · context
    Rat pups were injected ip with MTII (3 mg/kg body weight) or saline on postnatal day (P) 5 to P6, P10-P11, or P15-P16 at 1700 and 0900 h and then killed at 1300 h.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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