In patients with thyrotoxicosis, GH responsiveness to GHRP‑6 was significantly lower than in controls.
In plain wordsIn people with an overactive thyroid, GHRP‑6 raised growth hormone significantly less than in controls.
- Peptide
- GHRP-6
- Outcome
- DecreaseGH response to GHRP-6 in hyperthyroid patients versus controls
- Study
n = 18
- Comparator
- Controls
- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
- Studied dose
- 1 µg/kg · intravenousAs given in this study (human).
Measurements
- Peak GH
- 12.6 microg/l
- hyperthyroid
- Peak GH
- 26.7 microg/l
- controls
Source sentences
There was a significant decrease in GH responsiveness to ghrelin, GHRP-6 and GHRH in the hyperthyroid group compared to controls.
2 context sentences(design, population, supporting numbers)
In control subjects and hyperthyroid patients peak GH (microg/l; mean +/- SE) values after ghrelin injection (controls: 66.7 +/- 13.6; hyper: 19.3 +/- 2.4) were significantly higher than those obtained after GHRP-6 (controls: 26.7 +/- 5.1; hyper: 12.6 +/- 1.3) and GHRH (controls: 13.5 +/- 4.3; hyper: 5.3 +/- 1.3).
The aim of this study was to evaluate the effects of ghrelin (1 microg/kg), GHRP-6 (1 mug/kg) and GHRH (100 microg), i.v., on GH levels in 10 hyperthyroid patients and in 8 controls.