Oxytocin is not important for the control of gonadotrophin secretion in the late follicular phase of the cycle.

Vanakara P, Dafopoulos K, Papastergiopoulou L, Kallitsaris A, Papageorgiou I, Messinis IE

Clinical endocrinology4 Apr 2007Cited by 5 (Europe PMC)

PMID17408422DOI10.1111/j.1365-2265.2007.02818.xPepBankPUB-17408422

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialEfficacy outcome
In normally cycling women, a 3-hour intravenous oxytocin infusion did not change LH response to GnRH versus saline or atosiban.
In plain wordsIn women with normal cycles, oxytocin infusion did not change the LH hormone response to GnRH compared with saline or atosiban.
Peptide
Oxytocin
Outcome
No significant changeLH response to GnRH
Study
n = 12
Comparator
Saline infusion and atosiban infusion
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous · 3 hAs given in this study (human).
Source sentences
Summary
No significant differences in LH and FSH response to GnRH (sensitivity and reserve) during the 240-min experiment were found between the three cycles.
2 context sentences(design, population, supporting numbers)
Summary · context
When the diameter of the leading follicle was 15-16 mm, the women were infused intravenously (i.v.) for 3 h with normal saline (cycle 1), atosiban (cycle 2) or oxytocin (cycle 3).
Summary · context
The study included 12 normally cycling women aged 23-38 years.
Report a problemFND-1740842201
02HumanNon-randomized trialEfficacy outcome
In normally cycling women, a 3-hour intravenous oxytocin infusion did not change FSH response to GnRH versus saline or atosiban.
In plain wordsIn women with normal cycles, oxytocin infusion did not change the FSH hormone response to GnRH compared with saline or atosiban.
Peptide
Oxytocin
Outcome
No significant changeFSH response to GnRH
Study
n = 12
Comparator
Saline infusion and atosiban infusion
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous · 3 hAs given in this study (human).
Source sentences
Summary
No significant differences in LH and FSH response to GnRH (sensitivity and reserve) during the 240-min experiment were found between the three cycles.
2 context sentences(design, population, supporting numbers)
Summary · context
When the diameter of the leading follicle was 15-16 mm, the women were infused intravenously (i.v.) for 3 h with normal saline (cycle 1), atosiban (cycle 2) or oxytocin (cycle 3).
Summary · context
The study included 12 normally cycling women aged 23-38 years.
Report a problemFND-1740842202
03HumanNon-randomized trialEfficacy outcome
In normally cycling women, the time of LH surge onset after oxytocin infusion was similar to that after saline or atosiban.
In plain wordsIn women with normal cycles, the timing of the LH surge after oxytocin infusion was similar to that after saline or atosiban.
Peptide
Oxytocin
Outcome
No significant changeTime of LH surge onset
Study
n = 12
Comparator
Saline infusion and atosiban infusion
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous · 3 hAs given in this study (human).
Source sentences
Summary
The time of LH surge onset from the initiation of the infusion was similar in the three cycles.
2 context sentences(design, population, supporting numbers)
Summary · context
When the diameter of the leading follicle was 15-16 mm, the women were infused intravenously (i.v.) for 3 h with normal saline (cycle 1), atosiban (cycle 2) or oxytocin (cycle 3).
Summary · context
The study included 12 normally cycling women aged 23-38 years.
Report a problemFND-1740842203
04HumanNon-randomized trialEfficacy outcome
In normally cycling women, oestradiol levels after oxytocin infusion were similar to those after saline or atosiban.
In plain wordsIn women with normal cycles, oestradiol levels after oxytocin infusion were similar to those after saline or atosiban.
Peptide
Oxytocin
Outcome
No significant changeOestradiol levels
Study
n = 12
Comparator
Saline infusion and atosiban infusion
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous · 3 hAs given in this study (human).
Source sentences
Summary
Also similar in the three cycles were oestradiol (E2)
2 context sentences(design, population, supporting numbers)
Summary · context
When the diameter of the leading follicle was 15-16 mm, the women were infused intravenously (i.v.) for 3 h with normal saline (cycle 1), atosiban (cycle 2) or oxytocin (cycle 3).
Summary · context
The study included 12 normally cycling women aged 23-38 years.
Report a problemFND-1740842204
05HumanNon-randomized trialEfficacy outcome
In normally cycling women, gonadotrophin levels after oxytocin infusion were similar to those after saline or atosiban.
In plain wordsIn women with normal cycles, gonadotrophin hormone levels after oxytocin infusion were similar to those after saline or atosiban.
Peptide
Oxytocin
Outcome
No significant changeGonadotrophin levels
Study
n = 12
Comparator
Saline infusion and atosiban infusion
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous · 3 hAs given in this study (human).
Source sentences
Summary
Also similar in the three cycles were oestradiol (E2) and gonadotrophin levels as well as the 30-min response to GnRH for 48 h following the 3-h infusion.
2 context sentences(design, population, supporting numbers)
Summary · context
When the diameter of the leading follicle was 15-16 mm, the women were infused intravenously (i.v.) for 3 h with normal saline (cycle 1), atosiban (cycle 2) or oxytocin (cycle 3).
Summary · context
The study included 12 normally cycling women aged 23-38 years.
Report a problemFND-1740842205
06HumanNon-randomized trialEfficacy outcome
In normally cycling women, the 30-minute response to GnRH for 48 hours after oxytocin infusion was similar to that after saline or atosiban.
In plain wordsIn women with normal cycles, the pituitary response to GnRH over 48 hours after oxytocin infusion was similar to that after saline or atosiban.
Peptide
Oxytocin
Outcome
No significant change30-min pituitary response to GnRH for 48 h after infusion
Study
n = 12
Comparator
Saline infusion and atosiban infusion
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intravenous · 3 hAs given in this study (human).
Source sentences
Summary
Also similar in the three cycles were oestradiol (E2) and gonadotrophin levels as well as the 30-min response to GnRH for 48 h following the 3-h infusion.
2 context sentences(design, population, supporting numbers)
Summary · context
When the diameter of the leading follicle was 15-16 mm, the women were infused intravenously (i.v.) for 3 h with normal saline (cycle 1), atosiban (cycle 2) or oxytocin (cycle 3).
Summary · context
The study included 12 normally cycling women aged 23-38 years.
Report a problemFND-1740842206

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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