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Study · Animal study (in vivo) · rat · 2006

4 results

[Selank-induced normalizing effects on the integrative brain activity and biogenic amine level disorders due to antenatal hypoxia].

Semenova TP, Kozlovskaia MM, Zuĭkov AV, Kozlovskiĭ II, Zakharova NM, Andreeva LA

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Nov 2006

PMID17385425 (opens in a new tab)PepBankPUB-17385425
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult rats exposed to antenatal hypoxia, Selank increased sensory attention 2--3-fold.

    In plain wordsIn rats exposed to hypoxia before birth, Selank increased sensory attention about two to three times.

    Peptide
    Selank
    Outcome
    IncreaseSensory attention
    Study

    ratn: not reported in source

    antenatal hypoxia (gestation days 14-16)
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    300 mkg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    increased 2--3-fold (p < 0.01) the sensory attention, facilitated 1.5-fold the learning capacity (p < 0.01), normalized exploratory activity in the open field and hole board, and recovered the balance of serotonergic and noradrenergic brain system activity.
    1 context sentence
    Summary · context
    The effects of Selank synthetic analog of Tuftsin, representing the heptapeptide forming Thr-Lys-Pro-Arg-Pro-Gly-Pro, on behavior and serotonin/noradrenalin concentrations in brain were investigated in adult rats exposed to hypoxia during 14-16 days of gestation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult rats exposed to antenatal hypoxia, Selank facilitated learning capacity 1.5-fold.

    In plain wordsIn rats exposed to hypoxia before birth, Selank improved learning capacity about one and a half times.

    Peptide
    Selank
    Outcome
    IncreaseLearning capacity
    Study

    ratn: not reported in source

    antenatal hypoxia (gestation days 14-16)
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    300 mkg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    facilitated 1.5-fold the learning capacity (p < 0.01), normalized exploratory activity in the open field and hole board, and recovered the balance of serotonergic and noradrenergic brain system activity.
    1 context sentence
    Summary · context
    The effects of Selank synthetic analog of Tuftsin, representing the heptapeptide forming Thr-Lys-Pro-Arg-Pro-Gly-Pro, on behavior and serotonin/noradrenalin concentrations in brain were investigated in adult rats exposed to hypoxia during 14-16 days of gestation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult rats exposed to antenatal hypoxia, Selank normalized exploratory activity in the open field and hole board tests.

    In plain wordsIn rats exposed to hypoxia before birth, Selank brought exploratory behaviour back to normal in two behaviour tests.

    Peptide
    Selank
    Outcome
    Direction not reportedExploratory activity in open field and hole board
    Study

    ratn: not reported in source

    antenatal hypoxia (gestation days 14-16)
    Outcome group
    Anxiety and mood · Nervous system and cognition
    Studied dose
    300 mkg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    normalized exploratory activity in the open field and hole board
    1 context sentence
    Summary · context
    The effects of Selank synthetic analog of Tuftsin, representing the heptapeptide forming Thr-Lys-Pro-Arg-Pro-Gly-Pro, on behavior and serotonin/noradrenalin concentrations in brain were investigated in adult rats exposed to hypoxia during 14-16 days of gestation.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In adult rats exposed to antenatal hypoxia, Selank recovered the balance of serotonergic and noradrenergic brain system activity.

    In plain wordsIn rats exposed to hypoxia before birth, Selank restored the balance between two brain chemical systems.

    Peptide
    Selank
    Outcome
    Direction not reportedBalance of serotonergic and noradrenergic brain activity
    Study

    ratn: not reported in source

    antenatal hypoxia (gestation days 14-16)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    300 mkg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    recovered the balance of serotonergic and noradrenergic brain system activity
    1 context sentence
    Summary · context
    The effects of Selank synthetic analog of Tuftsin, representing the heptapeptide forming Thr-Lys-Pro-Arg-Pro-Gly-Pro, on behavior and serotonin/noradrenalin concentrations in brain were investigated in adult rats exposed to hypoxia during 14-16 days of gestation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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