[Protective effect of peptide semax (ACTH(4-7)Pro-Gly-Pro) on the rat heart rate after myocardial infarction].

Gavrilova SA, Golubeva AV, Lipina TV, Fominykh ES, Shornikova MV, Postnikov AB, Andrejeva LA, Chentsov IuS, Koshelev VB

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Nov 2006Cited by 1 (Europe PMC)

PMID17385423PepBankPUB-17385423

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats 28 days after myocardial infarction, semax did not affect cardiac work.
In plain wordsIn rats after a heart attack, semax did not change the work of the heart.
Peptide
Semax
Outcome
No significant changeCardiac work
Study
ratn: not reported in source
Myocardial infarction by left descendent coronary artery occlusion
Outcome group
Heart function · Cardiovascular
Studied dose
150 microg/kg · intraperitoneal · twice on the operating day, then once a day for 6 daysAs given in this study (rat).
Source sentences
Summary
Semax did not affect cardiac work
2 context sentences(design, population, supporting numbers)
Summary · context
We suggest that semax is also capable of protecting the rat heart from ischemic damage 28 days after myocardial infarction (MI) induced by left descendent coronary artery occlusion.
Summary · context
Semax (150 microg/kg) was given i. p. in the operating day twice: 15 min and 2 hours after coronary occlusion, and once a day for the following 6 days.
Report a problemFND-1738542301
02AnimalAnimal study (in vivo)Efficacy outcome
In rats 28 days after myocardial infarction, semax partially prevented the growth of end-diastolic pressure in the left ventricle.
In plain wordsIn rats after a heart attack, semax partly prevented the rise in pressure in the left heart chamber at rest.
Peptide
Semax
Outcome
DecreaseLeft ventricular end-diastolic pressure growth
Study
ratn: not reported in source
Myocardial infarction by left descendent coronary artery occlusion
Outcome group
Heart function · Cardiovascular
Studied dose
150 microg/kg · intraperitoneal · twice on the operating day, then once a day for 6 daysAs given in this study (rat).
Source sentences
Summary
partially prevented end-diastolic pressure growth in left ventricle
2 context sentences(design, population, supporting numbers)
Summary · context
We suggest that semax is also capable of protecting the rat heart from ischemic damage 28 days after myocardial infarction (MI) induced by left descendent coronary artery occlusion.
Summary · context
Semax (150 microg/kg) was given i. p. in the operating day twice: 15 min and 2 hours after coronary occlusion, and once a day for the following 6 days.
Report a problemFND-1738542302
03AnimalAnimal study (in vivo)Efficacy outcome
In rats 28 days after myocardial infarction, semax ameliorated cardiomyocyte hypertrophy.
In plain wordsIn rats after a heart attack, semax reduced the enlargement of heart muscle cells.
Peptide
Semax
Outcome
DecreaseCardiomyocyte hypertrophy
Study
ratn: not reported in source
Myocardial infarction by left descendent coronary artery occlusion
Outcome group
Heart function · Cardiovascular
Studied dose
150 microg/kg · intraperitoneal · twice on the operating day, then once a day for 6 daysAs given in this study (rat).
Source sentences
Summary
ameliorated cardiomyocyte hypertrophy
2 context sentences(design, population, supporting numbers)
Summary · context
We suggest that semax is also capable of protecting the rat heart from ischemic damage 28 days after myocardial infarction (MI) induced by left descendent coronary artery occlusion.
Summary · context
Semax (150 microg/kg) was given i. p. in the operating day twice: 15 min and 2 hours after coronary occlusion, and once a day for the following 6 days.
Report a problemFND-1738542303
04AnimalAnimal study (in vivo)Efficacy outcome
In rats 28 days after myocardial infarction, semax ameliorated the disproportionate growth of the contractile and mitochondrial apparatus of cardiomyocytes.
In plain wordsIn rats after a heart attack, semax reduced the uneven growth of contractile parts and mitochondria in heart muscle cells.
Peptide
Semax
Outcome
DecreaseDisproportionate growth of contractile and mitochondrial apparatus
Study
ratn: not reported in source
Myocardial infarction by left descendent coronary artery occlusion
Outcome group
Heart function · Cardiovascular
Studied dose
150 microg/kg · intraperitoneal · twice on the operating day, then once a day for 6 daysAs given in this study (rat).
Source sentences
Summary
disproportionate growth of contractile and mitochondrial apparatus
2 context sentences(design, population, supporting numbers)
Summary · context
We suggest that semax is also capable of protecting the rat heart from ischemic damage 28 days after myocardial infarction (MI) induced by left descendent coronary artery occlusion.
Summary · context
Semax (150 microg/kg) was given i. p. in the operating day twice: 15 min and 2 hours after coronary occlusion, and once a day for the following 6 days.
Report a problemFND-1738542304

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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