New GHK hydrophobic derivatives: interaction with phospholipid bilayers.

Almiñana N, Alsina MA, Reig F

Colloids and surfaces. B, Biointerfaces12 Feb 2007Cited by 3 (Europe PMC)

PMID17383163DOI10.1016/j.colsurfb.2007.02.006PepBankPUB-17383163

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

01LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cells)Safety outcome
In hemolysis tests, myristoyl-GHK produced total hemolysis at 2.5x10(-4)M.
In plain wordsIn lab tests, myristoyl-GHK produced total hemolysis at the reported concentration.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
IncreaseMyristoyl-GHK hemolysis
Study
n: not reported in source
hemolysis assay
Outcome group
Adverse events · Pharmacology
Source sentences
Summary
Besides, results indicate that myristoyl-GHK produces total hemolysis at 2.5x10(-4)M but decanoyl and hexanoyl derivatives at 5x10(-4)M induce only 10% of hemolysis.
1 context sentence(design, population, supporting numbers)
Summary · context
Three hydrophobic derivatives of GHK peptide containing either N-terminal hexanoyl, decanoyl or myristoyl acyl moieties were synthesized.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1738316305
02LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cells)Safety outcome
In hemolysis tests, decanoyl-GHK induced only 10% hemolysis at 5x10(-4)M.
In plain wordsIn lab tests, decanoyl-GHK induced only 10% hemolysis at the reported concentration.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
IncreaseDecanoyl-GHK hemolysis
Study
n: not reported in source
hemolysis assay
Outcome group
Adverse events · Pharmacology
Source sentences
Summary
Besides, results indicate that myristoyl-GHK produces total hemolysis at 2.5x10(-4)M but decanoyl and hexanoyl derivatives at 5x10(-4)M induce only 10% of hemolysis.
1 context sentence(design, population, supporting numbers)
Summary · context
Three hydrophobic derivatives of GHK peptide containing either N-terminal hexanoyl, decanoyl or myristoyl acyl moieties were synthesized.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1738316306
03LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cells)Safety outcome
In hemolysis tests, hexanoyl-GHK induced only 10% hemolysis at 5x10(-4)M.
In plain wordsIn lab tests, hexanoyl-GHK induced only 10% hemolysis at the reported concentration.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
IncreaseHexanoyl-GHK hemolysis
Study
n: not reported in source
hemolysis assay
Outcome group
Adverse events · Pharmacology
Source sentences
Summary
Besides, results indicate that myristoyl-GHK produces total hemolysis at 2.5x10(-4)M but decanoyl and hexanoyl derivatives at 5x10(-4)M induce only 10% of hemolysis.
1 context sentence(design, population, supporting numbers)
Summary · context
Three hydrophobic derivatives of GHK peptide containing either N-terminal hexanoyl, decanoyl or myristoyl acyl moieties were synthesized.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1738316307
04LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cell-free)Mechanism
In phospholipid bilayers, hydrophobic GHK derivatives showed high affinity for lipids ordered in liposomes.
In plain wordsIn lab tests, hydrophobic GHK derivatives showed high affinity for lipids in liposomes.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
Not applicableLipid binding affinity
Study
n: not reported in source
phospholipid bilayers
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Binding experiments indicate a high affinity of these peptidolipids for lipids ordered in liposomes.
1 context sentence(design, population, supporting numbers)
Summary · context
Three hydrophobic derivatives of GHK peptide containing either N-terminal hexanoyl, decanoyl or myristoyl acyl moieties were synthesized.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1738316301
05LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cell-free)Mechanism
In liposomes, binding of hydrophobic GHK derivatives did not promote entrapped carboxyfluorescein release.
In plain wordsIn lab tests, hydrophobic GHK derivatives did not promote dye release from liposomes.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
No significant changeCarboxyfluorescein release
Study
n: not reported in source
phospholipid bilayers
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Nevertheless, this interaction does not promote the release of entrapped carboxyfluorescein.
1 context sentence(design, population, supporting numbers)
Summary · context
Three hydrophobic derivatives of GHK peptide containing either N-terminal hexanoyl, decanoyl or myristoyl acyl moieties were synthesized.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1738316302
06LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cell-free)Mechanism
In bilayer experiments, GHK derivative association protected the surface and suggested external insertion of the hydrophobic moiety.
In plain wordsIn lab tests, GHK derivatives protected the bilayer surface, suggesting insertion of their hydrophobic portion.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
Not applicableBilayer association protection
Study
n: not reported in source
phospholipid bilayers
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Experiments carried out by the asymmetric membrane method (NBD-PE/dithionite) and quenching studies (PC-pyrene/KI) indicate that this association has a protective effect suggesting that the hydrophobic moiety inserts in the external part of the bilayer and the peptide chain remains protruding from t…
1 context sentence(design, population, supporting numbers)
Summary · context
Three hydrophobic derivatives of GHK peptide containing either N-terminal hexanoyl, decanoyl or myristoyl acyl moieties were synthesized.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1738316303
07LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cell-free)Mechanism
In DPPC bilayers, GHK peptidolipids did not affect microviscosity.
In plain wordsIn lab tests, GHK peptidolipids did not affect bilayer microviscosity.
Peptide
GHK (glycyl-L-histidyl-L-lysine)
Outcome
No significant changeDPPC bilayer microviscosity
Study
n: not reported in source
phospholipid bilayers
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
The microviscosity of DPPC bilayers determined using TMA-DPH as fluorescent marker was not affected by the presence of peptidolipids.
1 context sentence(design, population, supporting numbers)
Summary · context
Three hydrophobic derivatives of GHK peptide containing either N-terminal hexanoyl, decanoyl or myristoyl acyl moieties were synthesized.
In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).
Report a problemFND-1738316304

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

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Journal Article

MeSH terms

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