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Study · Ex vivo tissue · rat · 2006

3 results

Effects of delta sleep-inducing peptide on pre- and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats.

Grigor'ev VV, Ivanova TA, Kustova EA, Petrova LN, Serkova TP, Bachurin SO

Bulletin of experimental biology and medicine1 Aug 2006Cited by 6 (Europe PMC)

PMID17369935 (opens in a new tab)DOI10.1007/s10517-006-0323-9 (opens in a new tab)PepBankPUB-17369935
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rat hippocampal and cerebellar neurons, DSIP potentiated GABA-activated currents in a dose-dependent way.

    In plain wordsIn rat brain neurons, DSIP strengthened the current produced by the calming signal GABA, more at higher doses.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseGABA-activated currents in hippocampal and cerebellar neurons
    Study

    ratn: not reported in source

    Isolated rat neurons (cortex, hippocampus, cerebellum)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was shown that delta sleep-inducing peptide considerably and dose-dependently potentiates GABA-activated currents in these neurons
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide on GABA receptors of hippocampal and cerebellar neurons in rats.
  2. 02LabEx vivo tissueActivity measurement

    In rat cortical and hippocampal neurons, DSIP blocked NMDA-activated potentiation.

    In plain wordsIn rat brain neurons, DSIP blocked an effect that NMDA receptor activation normally produces.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseNMDA-activated potentiation in cortical and hippocampal neurons
    Study

    ratn: not reported in source

    Isolated rat neurons (cortex, hippocampus, cerebellum)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    blocks NMDA-activated potentiation in cortical and hippocampal neurons.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide on GABA receptors of hippocampal and cerebellar neurons in rats.
  3. 03LabEx vivo tissueActivity measurement

    In rat brain cortex synaptosomes, DSIP changed 45Ca2+ uptake after stimulation with glutamate and NMDA, which indicates modulation of presynaptic NMDA receptors.

    In plain wordsIn rat brain nerve-ending preparations, DSIP changed calcium uptake after glutamate and NMDA stimulation.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reported45Ca2+ uptake into cortical synaptosomes
    Study

    ratn: not reported in source

    Isolated rat neurons (cortex, hippocampus, cerebellum)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The peptide modulates activity of presynaptic NMDA receptors, which is seen from changes in (45)Ca(2+) uptake into synaptosomes of the brain cortex after uptake stimulation with glutamate and NMDA.
    1 context sentence
    Summary · context
    We studied the effect of delta sleep-inducing peptide on GABA receptors of hippocampal and cerebellar neurons in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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