Oxytocin infusion in laparoscopic myomectomy may decrease operative blood loss.

Wang CJ, Lee CL, Yuen LT, Kay N, Han CM, Soong YK

Journal of minimally invasive gynecology1 Mar 2007Cited by 41 (Europe PMC)

PMID17368254DOI10.1016/j.jmig.2006.09.016PepBankPUB-17368254

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanNon-randomized trialEfficacy outcome
In women having laparoscopic myomectomy, oxytocin infusion gave lower blood loss than no oxytocin infusion.
In plain wordsIn women having fibroid surgery, an oxytocin infusion was linked to less blood loss than no infusion.
Peptide
Oxytocin
Outcome
DecreaseOperative blood loss
Study
n = 60
Comparator
No oxytocin infusion
Outcome group
Bleeding and clotting · Reproductive and sexual health
Studied dose
40 mU/min · during laparoscopic myomectomyAs given in this study (human).
Measurements
Blood loss
269.5 mL
oxytocin infusion group A
Blood loss
445 mL
no oxytocin group B
Source sentences
Summary
Blood loss and blood transfusion rate were significantly greater in the group without oxytocin infusion (group B) than in the group with oxytocin infusion (group A), with 445.0 +/- 268.6 mL (95% CI 344.7-545.3) versus 269.5 +/- 225.8 mL (95% CI 185.2-353.8)/(p <.05), and 36.7% versus 6.7% (p <.05), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty women scheduled for myomectomy because of symptomatic uterine myomas.
Summary · context
Two ampules of oxytocin (10 u/mL/amp) were added to 1000 mL of saline solution running at the rate of 40 mU/min during the course of LM.
Report a problemFND-1736825401
02HumanNon-randomized trialEfficacy outcome
In women having laparoscopic myomectomy, oxytocin infusion gave a lower blood transfusion rate than no oxytocin infusion.
In plain wordsIn women having fibroid surgery, fewer needed a blood transfusion with an oxytocin infusion than without it.
Peptide
Oxytocin
Outcome
DecreaseBlood transfusion rate
Study
n = 60
Comparator
No oxytocin infusion
Outcome group
Bleeding and clotting · Reproductive and sexual health
Studied dose
40 mU/min · during laparoscopic myomectomyAs given in this study (human).
Measurements
Transfusion rate
6.7%
oxytocin infusion group A
Transfusion rate
36.7%
no oxytocin group B
Source sentences
Summary
Blood loss and blood transfusion rate were significantly greater in the group without oxytocin infusion (group B) than in the group with oxytocin infusion (group A), with 445.0 +/- 268.6 mL (95% CI 344.7-545.3) versus 269.5 +/- 225.8 mL (95% CI 185.2-353.8)/(p <.05), and 36.7% versus 6.7% (p <.05), respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty women scheduled for myomectomy because of symptomatic uterine myomas.
Summary · context
Two ampules of oxytocin (10 u/mL/amp) were added to 1000 mL of saline solution running at the rate of 40 mU/min during the course of LM.
Report a problemFND-1736825402
03HumanNon-randomized trialEfficacy outcome
In women having laparoscopic myomectomy, postoperative stay did not differ significantly between oxytocin infusion and no oxytocin infusion.
In plain wordsIn women having fibroid surgery, length of hospital stay after surgery did not differ significantly between the oxytocin and no-oxytocin groups.
Peptide
Oxytocin
Outcome
No significant changePostoperative stay
Study
n = 60
Comparator
No oxytocin infusion
Outcome group
Intensive care and hospital outcomes · Reproductive and sexual health
Studied dose
40 mU/min · during laparoscopic myomectomyAs given in this study (human).
Source sentences
Summary
There was no significant difference in mean total myoma weight, main myoma size, postoperative stay, and complications between the 2 groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty women scheduled for myomectomy because of symptomatic uterine myomas.
Summary · context
Two ampules of oxytocin (10 u/mL/amp) were added to 1000 mL of saline solution running at the rate of 40 mU/min during the course of LM.
Report a problemFND-1736825403
04HumanNon-randomized trialSafety outcome
In women having laparoscopic myomectomy, complication rates did not differ significantly between oxytocin infusion and no oxytocin infusion.
In plain wordsIn women having fibroid surgery, complications did not differ significantly between the oxytocin and no-oxytocin groups.
Peptide
Oxytocin
Outcome
No significant changeComplications
Study
n = 60
Comparator
No oxytocin infusion
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
40 mU/min · during laparoscopic myomectomyAs given in this study (human).
Source sentences
Summary
There was no significant difference in mean total myoma weight, main myoma size, postoperative stay, and complications between the 2 groups.
2 context sentences(design, population, supporting numbers)
Summary · context
Sixty women scheduled for myomectomy because of symptomatic uterine myomas.
Summary · context
Two ampules of oxytocin (10 u/mL/amp) were added to 1000 mL of saline solution running at the rate of 40 mU/min during the course of LM.
Report a problemFND-1736825404

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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