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Study · Animal study (in vivo) · rat · 2007

5 results

Neurotrophin gene expression in rat brain under the action of Semax, an analogue of ACTH 4-10.

Agapova TY, Agniullin YV, Shadrina MI, Shram SI, Slominsky PA, Lymborska SA, Myasoedov NF

Neuroscience letters20 Feb 2007Cited by 10 (Europe PMC)

PMID17353092 (opens in a new tab)DOI10.1016/j.neulet.2007.02.042 (opens in a new tab)PepBankPUB-17353092
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In normal rats, intranasal Semax increased Ngf gene expression in the hippocampus.

    In plain wordsIn rats, a nasal dose of Semax raised Ngf gene activity in the hippocampus within an hour.

    Peptide
    Semax
    Outcome
    IncreaseNgf gene expression in hippocampus
    Study

    ratn: not reported in source

    Normal male Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50 microg/kg · intranasal · single application, 1 hAs given in this study (rat).

    Source sentences

    Summary
    It was revealed that an intranasal application of Semax increased the expression of both neurotrophin genes in rat hippocampus.
    1 context sentence
    Summary · context
    Male Wistar rats were treated for 1h with Semax (50 microg/kg, single intranasal application) and neurotrophin gene expression in rat brain was analyzed by real-time polymerase chain reaction (PCR).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In normal rats, intranasal Semax increased Bdnf gene expression in the hippocampus.

    In plain wordsIn rats, a nasal dose of Semax raised Bdnf gene activity in the hippocampus within an hour.

    Peptide
    Semax
    Outcome
    IncreaseBdnf gene expression in hippocampus
    Study

    ratn: not reported in source

    Normal male Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50 microg/kg · intranasal · single application, 1 hAs given in this study (rat).

    Source sentences

    Summary
    It was revealed that an intranasal application of Semax increased the expression of both neurotrophin genes in rat hippocampus.
    1 context sentence
    Summary · context
    Male Wistar rats were treated for 1h with Semax (50 microg/kg, single intranasal application) and neurotrophin gene expression in rat brain was analyzed by real-time polymerase chain reaction (PCR).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In normal rats, Semax increased Bdnf gene expression in the brainstem.

    In plain wordsIn rats, a nasal dose of Semax raised Bdnf gene activity in the brainstem.

    Peptide
    Semax
    Outcome
    IncreaseBdnf gene expression in brainstem
    Study

    ratn: not reported in source

    Normal male Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50 microg/kg · intranasal · single application, 1 hAs given in this study (rat).

    Source sentences

    Summary
    Bdnf gene expression also increased in the brainstem and cerebellum.
    1 context sentence
    Summary · context
    Male Wistar rats were treated for 1h with Semax (50 microg/kg, single intranasal application) and neurotrophin gene expression in rat brain was analyzed by real-time polymerase chain reaction (PCR).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In normal rats, Semax increased Bdnf gene expression in the cerebellum.

    In plain wordsIn rats, a nasal dose of Semax raised Bdnf gene activity in the cerebellum.

    Peptide
    Semax
    Outcome
    IncreaseBdnf gene expression in cerebellum
    Study

    ratn: not reported in source

    Normal male Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50 microg/kg · intranasal · single application, 1 hAs given in this study (rat).

    Source sentences

    Summary
    Bdnf gene expression also increased in the brainstem and cerebellum.
    1 context sentence
    Summary · context
    Male Wistar rats were treated for 1h with Semax (50 microg/kg, single intranasal application) and neurotrophin gene expression in rat brain was analyzed by real-time polymerase chain reaction (PCR).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In normal rats, Semax decreased Ngf gene expression in the frontal cortex.

    In plain wordsIn rats, a nasal dose of Semax lowered Ngf gene activity in the frontal cortex.

    Peptide
    Semax
    Outcome
    DecreaseNgf gene expression in frontal cortex
    Study

    ratn: not reported in source

    Normal male Wistar rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50 microg/kg · intranasal · single application, 1 hAs given in this study (rat).

    Source sentences

    Summary
    Ngf gene expression decreased in rat frontal cortex.
    1 context sentence
    Summary · context
    Male Wistar rats were treated for 1h with Semax (50 microg/kg, single intranasal application) and neurotrophin gene expression in rat brain was analyzed by real-time polymerase chain reaction (PCR).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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