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Study · Not a test of the peptide alone · 2007

3 results

Neuroprotective peptides prevent some alcohol-induced alteration in gamma-aminobutyric acid A-beta3, which plays a role in cleft lip and palate and learning in fetal alcohol syndrome.

Toso L, Roberson R, Abebe D, Spong CY

American journal of obstetrics and gynecology1 Mar 2007Cited by 9 (Europe PMC)

PMID17346546 (opens in a new tab)DOI10.1016/j.ajog.2007.01.015 (opens in a new tab)PepBankPUB-17346546
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Davunetide.

  1. 01AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism

    In alcohol-exposed mouse embryos, NAP+SAL prevented the GABAbeta3 decrease twenty-four hours after treatment.

    In plain wordsIn mouse embryos, NAP+SAL prevented reduced GABAbeta3 expression twenty-four hours after alcohol exposure compared with alcohol alone.

    Peptide
    Davunetide
    Outcome
    IncreaseEmbryonic GABAbeta3 expression at twenty-four hours
    Study

    Mousen: not reported in source

    Prenatal alcohol exposure in C57B16/J mice
    Comparator
    Alcohol alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Twenty-four hours and 10 days after treatment, alcohol decreased GABAbeta3 in the embryos (P < or = .01); this decrease was prevented by the peptides (P = .01).
    2 context sentences
    Summary · context
    With a model for fetal alcohol syndrome, timed pregnant C57B16/J mice were treated on gestational day 8 with alcohol (25% alcohol) or control (saline solution) or alcohol plus peptides NAPVSIPQ + SALLRSIPA (NAP + SAL; 20 microg).
    Summary · context
    Embryos were harvested at 6 and 24 hours and 10 days after treatment.

    In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.

  2. 02AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism

    In alcohol-exposed mouse embryos, NAP+SAL prevented the GABAbeta3 decrease 10 days after treatment.

    In plain wordsIn mouse embryos, NAP+SAL prevented reduced GABAbeta3 expression 10 days after alcohol exposure compared with alcohol alone.

    Peptide
    Davunetide
    Outcome
    IncreaseEmbryonic GABAbeta3 expression at ten days
    Study

    Mousen: not reported in source

    Prenatal alcohol exposure in C57B16/J mice
    Comparator
    Alcohol alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Twenty-four hours and 10 days after treatment, alcohol decreased GABAbeta3 in the embryos (P < or = .01); this decrease was prevented by the peptides (P = .01).
    2 context sentences
    Summary · context
    With a model for fetal alcohol syndrome, timed pregnant C57B16/J mice were treated on gestational day 8 with alcohol (25% alcohol) or control (saline solution) or alcohol plus peptides NAPVSIPQ + SALLRSIPA (NAP + SAL; 20 microg).
    Summary · context
    Embryos were harvested at 6 and 24 hours and 10 days after treatment.

    In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.

  3. 03AnimalNot a test of Davunetide aloneAnimal study (in vivo)Mechanism

    In adult mice exposed prenatally to alcohol, NAP+SAL did not prevent elevated brain GABAbeta3.

    In plain wordsIn adult mice exposed prenatally to alcohol, NAP+SAL did not prevent elevated brain GABAbeta3 compared with alcohol alone.

    Peptide
    Davunetide
    Outcome
    Not applicableAdult brain GABAbeta3 elevation
    Study

    Mousen: not reported in source

    Prenatal alcohol exposure in C57B16/J mice
    Comparator
    Alcohol alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    GABAbeta3 was higher in alcohol treated adult brains respect to the controls (P = .002); this rise was not prevented by the peptides.
    2 context sentences
    Summary · context
    With a model for fetal alcohol syndrome, timed pregnant C57B16/J mice were treated on gestational day 8 with alcohol (25% alcohol) or control (saline solution) or alcohol plus peptides NAPVSIPQ + SALLRSIPA (NAP + SAL; 20 microg).
    Summary · context
    Embryos were harvested at 6 and 24 hours and 10 days after treatment.

    In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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