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Study · Animal study (in vivo) · rat · 2006

8 results

[Changes in the focus of experimental ischemic stroke under the influence of neuroprotective drugs].

Onishchenko LS, Gaĭkova ON, Ianishevskiĭ SN

Morfologiia (Saint Petersburg, Russia)1 Jan 2006Cited by 4 (Europe PMC)

PMID17338215 (opens in a new tab)PepBankPUB-17338215
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats with ischemic stroke, the reported alpha-GPC or Cerebrolysin treatments increased neuronal tolerance to ischemic damage.

    In plain wordsIn rats with ischemic stroke, alpha-GPC or Cerebrolysin treatments increased neuronal tolerance to injury.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuronal tolerance to ischemia
    Study

    ratn: not reported in source

    Temporary cerebral ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with alpha-GPC or cerebrolysin resulted in an increased tolerance of neurons to ischemic damage and in delayed realization of the program of cell death.
    2 context sentences
    Summary · context
    Temporary disturbance of cerebral circulation (acute ischemia) in right cerebral hemisphere was induced by clipping the trunk of innominate artery for 40 minutes.
    Summary · context
    Areas of cerebral cortex, brainstem and cerebellar cortex were studied using light and electron microscopy.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with ischemic stroke, the reported alpha-GPC or Cerebrolysin treatments delayed the cell-death program.

    In plain wordsIn rats with ischemic stroke, alpha-GPC or Cerebrolysin treatments delayed cell death.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseDelay of cell death
    Study

    ratn: not reported in source

    Temporary cerebral ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with alpha-GPC or cerebrolysin resulted in an increased tolerance of neurons to ischemic damage and in delayed realization of the program of cell death.
    2 context sentences
    Summary · context
    Temporary disturbance of cerebral circulation (acute ischemia) in right cerebral hemisphere was induced by clipping the trunk of innominate artery for 40 minutes.
    Summary · context
    Areas of cerebral cortex, brainstem and cerebellar cortex were studied using light and electron microscopy.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with ischemic stroke, alpha-GPC or Cerebrolysin treatment produced nuclear envelope indentation, interpreted as a possible adaptation or repair sign.

    In plain wordsIn rats with ischemic stroke, alpha-GPC or Cerebrolysin produced nuclear envelope indentation, interpreted as a possible adaptation or repair sign.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableNuclear envelope indentation
    Study

    ratn: not reported in source

    Temporary cerebral ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Some intracellular changes were detected that could be regarded as the signs of adaptation and repair (indentation of nuclear envelope, increased number of ribosomes, hypertrophy of endoplasmic reticulum and Golgi complex).
    3 context sentences
    Summary · context
    Treatment with alpha-GPC or cerebrolysin resulted in an increased tolerance of neurons to ischemic damage and in delayed realization of the program of cell death.
    Summary · context
    Temporary disturbance of cerebral circulation (acute ischemia) in right cerebral hemisphere was induced by clipping the trunk of innominate artery for 40 minutes.
    Summary · context
    Areas of cerebral cortex, brainstem and cerebellar cortex were studied using light and electron microscopy.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with ischemic stroke, the reported alpha-GPC or Cerebrolysin treatments preserved nuclear membrane structure.

    In plain wordsIn rats with ischemic stroke, alpha-GPC or Cerebrolysin treatments preserved nuclear membranes.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableNuclear membrane structure
    Study

    ratn: not reported in source

    Temporary cerebral ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These drugs preserved the structure of the membranes in the nucleus and major organelles.
    3 context sentences
    Summary · context
    Treatment with alpha-GPC or cerebrolysin resulted in an increased tolerance of neurons to ischemic damage and in delayed realization of the program of cell death.
    Summary · context
    Temporary disturbance of cerebral circulation (acute ischemia) in right cerebral hemisphere was induced by clipping the trunk of innominate artery for 40 minutes.
    Summary · context
    Areas of cerebral cortex, brainstem and cerebellar cortex were studied using light and electron microscopy.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with ischemic stroke, the reported alpha-GPC or Cerebrolysin treatments preserved membrane structure in major organelles.

    In plain wordsIn rats with ischemic stroke, alpha-GPC or Cerebrolysin treatments preserved organelle membranes.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableOrganelle membrane structure
    Study

    ratn: not reported in source

    Temporary cerebral ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These drugs preserved the structure of the membranes in the nucleus and major organelles.
    3 context sentences
    Summary · context
    Treatment with alpha-GPC or cerebrolysin resulted in an increased tolerance of neurons to ischemic damage and in delayed realization of the program of cell death.
    Summary · context
    Temporary disturbance of cerebral circulation (acute ischemia) in right cerebral hemisphere was induced by clipping the trunk of innominate artery for 40 minutes.
    Summary · context
    Areas of cerebral cortex, brainstem and cerebellar cortex were studied using light and electron microscopy.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with ischemic stroke, alpha-GPC or Cerebrolysin treatment increased ribosome numbers, interpreted as a possible adaptation or repair sign.

    In plain wordsIn rats with ischemic stroke, alpha-GPC or Cerebrolysin increased ribosome numbers, interpreted as a possible adaptation or repair sign.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseRibosome number
    Study

    ratn: not reported in source

    Temporary cerebral ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Some intracellular changes were detected that could be regarded as the signs of adaptation and repair (indentation of nuclear envelope, increased number of ribosomes, hypertrophy of endoplasmic reticulum and Golgi complex).
    2 context sentences
    Summary · context
    Treatment with alpha-GPC or cerebrolysin resulted in an increased tolerance of neurons to ischemic damage and in delayed realization of the program of cell death.
    Summary · context
    Temporary disturbance of cerebral circulation (acute ischemia) in right cerebral hemisphere was induced by clipping the trunk of innominate artery for 40 minutes.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with ischemic stroke, alpha-GPC or Cerebrolysin treatment produced endoplasmic reticulum hypertrophy, interpreted as a possible adaptation or repair sign.

    In plain wordsIn rats with ischemic stroke, alpha-GPC or Cerebrolysin enlarged the endoplasmic reticulum, interpreted as a possible adaptation or repair sign.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableEndoplasmic reticulum hypertrophy
    Study

    ratn: not reported in source

    Temporary cerebral ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Some intracellular changes were detected that could be regarded as the signs of adaptation and repair (indentation of nuclear envelope, increased number of ribosomes, hypertrophy of endoplasmic reticulum and Golgi complex).
    2 context sentences
    Summary · context
    Treatment with alpha-GPC or cerebrolysin resulted in an increased tolerance of neurons to ischemic damage and in delayed realization of the program of cell death.
    Summary · context
    Temporary disturbance of cerebral circulation (acute ischemia) in right cerebral hemisphere was induced by clipping the trunk of innominate artery for 40 minutes.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with ischemic stroke, alpha-GPC or Cerebrolysin treatment produced Golgi complex hypertrophy, interpreted as a possible adaptation or repair sign.

    In plain wordsIn rats with ischemic stroke, alpha-GPC or Cerebrolysin enlarged the Golgi complex, interpreted as a possible adaptation or repair sign.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableGolgi complex hypertrophy
    Study

    ratn: not reported in source

    Temporary cerebral ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Some intracellular changes were detected that could be regarded as the signs of adaptation and repair (indentation of nuclear envelope, increased number of ribosomes, hypertrophy of endoplasmic reticulum and Golgi complex).
    2 context sentences
    Summary · context
    Treatment with alpha-GPC or cerebrolysin resulted in an increased tolerance of neurons to ischemic damage and in delayed realization of the program of cell death.
    Summary · context
    Temporary disturbance of cerebral circulation (acute ischemia) in right cerebral hemisphere was induced by clipping the trunk of innominate artery for 40 minutes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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