Central administration of vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide differentially regulates energy metabolism in chicks.

Tachibana T, Oikawa D, Adachi N, Boswell T, Boswell T, Furuse M

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology16 Jan 2007Cited by 16 (Europe PMC)

PMID17291802DOI10.1016/j.cbpa.2006.12.043PepBankPUB-17291802

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In chicks, intracerebroventricular VIP did not significantly change rectal temperature.
In plain wordsIn chicks, VIP injected into the brain did not significantly change body temperature.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeRectal temperature
Study
domestic chickn: not reported in source
Intracerebroventricular injection in chicks
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (domestic chick).
Source sentences
Summary
I.c.v. injection of VIP did not significantly affect rectal temperature
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was to investigate whether intracerebroventricular (i.c.v.) injection of VIP and PACAP acts in a similar or different manner to affect body temperature and energy expenditure in the domestic chick.
Report a problemFND-1729180201
02AnimalAnimal study (in vivo)Efficacy outcome
In chicks, intracerebroventricular VIP decreased energy expenditure.
In plain wordsIn chicks, VIP injected into the brain lowered energy expenditure.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseEnergy expenditure
Study
domestic chickn: not reported in source
Intracerebroventricular injection in chicks
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (domestic chick).
Source sentences
Summary
but decreased energy expenditure.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was to investigate whether intracerebroventricular (i.c.v.) injection of VIP and PACAP acts in a similar or different manner to affect body temperature and energy expenditure in the domestic chick.
Report a problemFND-1729180202
03AnimalAnimal study (in vivo)Efficacy outcome
In chicks, central administration of VIP reduced the respiratory quotient.
In plain wordsIn chicks, VIP given in the brain lowered the respiratory quotient, a measure of which fuel the body burns.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseRespiratory quotient
Study
domestic chickn: not reported in source
Intracerebroventricular injection in chicks
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (domestic chick).
Source sentences
Summary
central administration of both VIP and PACAP induced a reduction in respiratory quotient and increased plasma non-esterified fatty acid concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was to investigate whether intracerebroventricular (i.c.v.) injection of VIP and PACAP acts in a similar or different manner to affect body temperature and energy expenditure in the domestic chick.
Report a problemFND-1729180203
04AnimalAnimal study (in vivo)Efficacy outcome
In chicks, central administration of VIP increased plasma non-esterified fatty acid concentrations.
In plain wordsIn chicks, VIP given in the brain raised blood fatty acid levels.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePlasma non-esterified fatty acids
Study
domestic chickn: not reported in source
Intracerebroventricular injection in chicks
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (domestic chick).
Source sentences
Summary
central administration of both VIP and PACAP induced a reduction in respiratory quotient and increased plasma non-esterified fatty acid concentrations
1 context sentence(design, population, supporting numbers)
Summary · context
The aim of the present study was to investigate whether intracerebroventricular (i.c.v.) injection of VIP and PACAP acts in a similar or different manner to affect body temperature and energy expenditure in the domestic chick.
Report a problemFND-1729180204

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

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