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Study · Animal study (in vivo) · mouse · 2007

4 results

The effects of the EW dipeptide optical and chemical isomers on the CFU-S population in intact and irradiated mice.

Deigin VI, Semenets TN, Zamulaeva IA, Maliutina YV, Selivanova EI, Saenko AS, Semina OV

International immunopharmacology20 Dec 2006Cited by 13 (Europe PMC)

PMID17276896 (opens in a new tab)DOI10.1016/j.intimp.2006.11.010 (opens in a new tab)PepBankPUB-17276896
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In irradiated mice, post-irradiation injection of L-Glu-L-Trp promoted regeneration of the hemopoietic progenitor population.

    In plain wordsIn mice, L-Glu-L-Trp promoted blood progenitor regeneration when injected after irradiation.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseProgenitor regeneration after post-irradiation L-Glu peptides
    Study

    mousen: not reported in source

    bone marrow
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    In animals, pre-irradiation injection of D-Glu-D-Trp, D-gammaGlu-D-Trp, D-Glu-L-Trp, D-gammaGlu-L-Trp, or post-irradiation injection of L-Glu-L-Trp, L-gammaGlu-L-Trp promoted regeneration of the hemopoietic progenitor population.

Studies that did not test the peptide alone3

In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymogen (oglufanide).

  1. 02AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Activity measurement

    In mice, D-Glu-containing Glu-Trp isomers inhibited hemopoietic progenitor proliferation in intact marrow.

    In plain wordsIn mice, the tested D-Glu-containing Glu-Trp isomers reduced blood progenitor cell multiplication in intact marrow.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreaseHemopoietic progenitor proliferation with D-Glu isomers
    Study

    mousen: not reported in source

    bone marrow
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The inversion of the amino acid optical form imparts suppressor properties: D-Glu-D-Trp,D--gammaGlu-D-Trp, D-Glu-L-Trp and D-gammaGlu-L-Trp inhibit proliferation of hemopoietic progenitors in intact bone marrow.

    In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).

  2. 03AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Activity measurement

    In mice, L-gammaGlu-D-Trp stimulated intact marrow CFU-S-8 proliferation, unlike alpha-linked L-Glu-D-Trp.

    In plain wordsIn mice, L-gammaGlu-D-Trp stimulated blood progenitor cell multiplication, unlike alpha-linked L-Glu-D-Trp.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseCFU-S-8 proliferation with gamma-linked isomer
    Study

    mousen: not reported in source

    bone marrow
    Comparator
    L-Glu-D-Trp with alpha-peptide bond
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Unlike L-Glu-D-Trp with alpha-peptide bond, the dipeptide L-gammaGlu-D-Trp with gamma-peptide bond stimulates CFU-S-8 proliferation in intact bone marrow.

    In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).

  3. 04AnimalNot a test of Thymogen (oglufanide) aloneAnimal study (in vivo)Activity measurement

    In irradiated mice, pre-irradiation injection of D-Glu-containing Glu-Trp isomers promoted hemopoietic progenitor regeneration.

    In plain wordsIn mice, the tested D-Glu-containing Glu-Trp isomers promoted blood progenitor regeneration when injected before irradiation.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseProgenitor regeneration after pre-irradiation D-Glu isomers
    Study

    mousen: not reported in source

    bone marrow
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    In animals, pre-irradiation injection of D-Glu-D-Trp, D-gammaGlu-D-Trp, D-Glu-L-Trp, D-gammaGlu-L-Trp, or post-irradiation injection of L-Glu-L-Trp, L-gammaGlu-L-Trp promoted regeneration of the hemopoietic progenitor population.

    In this study, Thymogen (oglufanide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymogen (oglufanide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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