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Study · Animal study (in vivo) · rat · 2007

5 results

High-dose atorvastatin causes regression of endometriotic implants: a rat model.

Oktem M, Esinler I, Eroglu D, Haberal N, Bayraktar N, Zeyneloglu HB

Human reproduction (Oxford, England)18 Jan 2007Cited by 65 (Europe PMC)

PMID17234677 (opens in a new tab)DOI10.1093/humrep/del505 (opens in a new tab)PepBankPUB-17234677
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with endometriosis, leuprolide reduced implant area from 41.2 to 13.1 mm(2).

    In plain wordsIn rats with endometriosis, implant area decreased from baseline with leuprolide.

    Peptide
    Leuprolide
    Outcome
    DecreaseImplant area change
    Study

    ratn = 9

    Wistar-Albino rats with experimentally induced endometriosis
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kg single dose · subcutaneous · 21 daysAs given in this study (rat).

    Measurements

    Baseline area
    41.2 mm(2)
    leuprolide
    Final area
    13.1 mm(2)
    leuprolide

    Source sentences

    Summary
    decreased from 41.2 +/- 18.1 to 13.1 +/- 13.8 mm(2) in Group III (both P < 0.05)
    4 context sentences
    Summary · context
    Thirty-seven Wistar-Albino rats in which endometriotic implants were induced were randomly divided into four groups.
    Summary · context
    Group III were given a single dose of 1 mg kg(-1) s.c. leuprolide acetate (GnRH agonist group, nine rats).
    Summary · context
    Group IV were given no medication and served as controls (10 rats).
    Summary · context
    All rats received the treatment for 21 days and were then euthanized to assess the implants' size, vascular endothelial growth factor (VEGF) level in peritoneal fluid and histological score.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with endometriosis, leuprolide produced smaller implant areas than low-dose atorvastatin.

    In plain wordsIn rats with endometriosis, leuprolide produced smaller implant areas than low-dose atorvastatin.

    Peptide
    Leuprolide
    Outcome
    DecreaseImplant area
    Study

    ratn: not reported in source

    Wistar-Albino rats with experimentally induced endometriosis
    Comparator
    Low-dose atorvastatin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kg single dose · subcutaneous · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    At the end of the treatment, the mean areas of implants were smaller and VEGF levels in peritoneal fluid were lower in Groups II and III than those in Group I and the control group (all P < 0.05).
    4 context sentences
    Summary · context
    Thirty-seven Wistar-Albino rats in which endometriotic implants were induced were randomly divided into four groups.
    Summary · context
    Group III were given a single dose of 1 mg kg(-1) s.c. leuprolide acetate (GnRH agonist group, nine rats).
    Summary · context
    Group IV were given no medication and served as controls (10 rats).
    Summary · context
    All rats received the treatment for 21 days and were then euthanized to assess the implants' size, vascular endothelial growth factor (VEGF) level in peritoneal fluid and histological score.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with endometriosis, leuprolide produced smaller implant areas than untreated controls.

    In plain wordsIn rats with endometriosis, leuprolide produced smaller implant areas than untreated controls.

    Peptide
    Leuprolide
    Outcome
    DecreaseImplant area
    Study

    ratn: not reported in source

    Wistar-Albino rats with experimentally induced endometriosis
    Comparator
    Untreated controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kg single dose · subcutaneous · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    At the end of the treatment, the mean areas of implants were smaller and VEGF levels in peritoneal fluid were lower in Groups II and III than those in Group I and the control group (all P < 0.05).
    4 context sentences
    Summary · context
    Thirty-seven Wistar-Albino rats in which endometriotic implants were induced were randomly divided into four groups.
    Summary · context
    Group III were given a single dose of 1 mg kg(-1) s.c. leuprolide acetate (GnRH agonist group, nine rats).
    Summary · context
    Group IV were given no medication and served as controls (10 rats).
    Summary · context
    All rats received the treatment for 21 days and were then euthanized to assess the implants' size, vascular endothelial growth factor (VEGF) level in peritoneal fluid and histological score.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with endometriosis, leuprolide produced lower peritoneal VEGF levels than low-dose atorvastatin.

    In plain wordsIn rats with endometriosis, leuprolide produced lower peritoneal VEGF levels than low-dose atorvastatin.

    Peptide
    Leuprolide
    Outcome
    DecreasePeritoneal VEGF
    Study

    ratn: not reported in source

    Wistar-Albino rats with experimentally induced endometriosis
    Comparator
    Low-dose atorvastatin
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    1 mg/kg single dose · subcutaneous · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    At the end of the treatment, the mean areas of implants were smaller and VEGF levels in peritoneal fluid were lower in Groups II and III than those in Group I and the control group (all P < 0.05).
    4 context sentences
    Summary · context
    Thirty-seven Wistar-Albino rats in which endometriotic implants were induced were randomly divided into four groups.
    Summary · context
    Group III were given a single dose of 1 mg kg(-1) s.c. leuprolide acetate (GnRH agonist group, nine rats).
    Summary · context
    Group IV were given no medication and served as controls (10 rats).
    Summary · context
    All rats received the treatment for 21 days and were then euthanized to assess the implants' size, vascular endothelial growth factor (VEGF) level in peritoneal fluid and histological score.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with endometriosis, leuprolide produced lower peritoneal VEGF levels than untreated controls.

    In plain wordsIn rats with endometriosis, leuprolide produced lower peritoneal VEGF levels than untreated controls.

    Peptide
    Leuprolide
    Outcome
    DecreasePeritoneal VEGF
    Study

    ratn: not reported in source

    Wistar-Albino rats with experimentally induced endometriosis
    Comparator
    Untreated controls
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    1 mg/kg single dose · subcutaneous · 21 daysAs given in this study (rat).

    Source sentences

    Summary
    At the end of the treatment, the mean areas of implants were smaller and VEGF levels in peritoneal fluid were lower in Groups II and III than those in Group I and the control group (all P < 0.05).
    4 context sentences
    Summary · context
    Thirty-seven Wistar-Albino rats in which endometriotic implants were induced were randomly divided into four groups.
    Summary · context
    Group III were given a single dose of 1 mg kg(-1) s.c. leuprolide acetate (GnRH agonist group, nine rats).
    Summary · context
    Group IV were given no medication and served as controls (10 rats).
    Summary · context
    All rats received the treatment for 21 days and were then euthanized to assess the implants' size, vascular endothelial growth factor (VEGF) level in peritoneal fluid and histological score.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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