GABA-mediated oxytocinergic inhibition in dorsal horn neurons by hypothalamic paraventricular nucleus stimulation.

Rojas-Piloni G, López-Hidalgo M, Martínez-Lorenzana G, Rodríguez-Jiménez J, Condés-Lara M

Brain research22 Dec 2006Cited by 60 (Europe PMC)

PMID17229405DOI10.1016/j.brainres.2006.12.045PepBankPUB-17229405

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anaesthetized rats, electrical stimulation of the paraventricular nucleus inhibited Adelta, C-fiber and post-discharge peripheral responses of dorsal horn WDR neurons.
In plain wordsIn anaesthetized rats, stimulating a brain area called the PVN reduced pain-related nerve cell responses in the spinal cord.
Peptide
Oxytocin
Outcome
DecreasePeripheral-evoked responses of WDR cells during PVN stimulation
Study
ratn: not reported in source
Anaesthetized rats, dorsal horn neuron recordings with PVN stimulation
Outcome group
Pain · Nervous system and cognition
Measurements
Adelta response change
−55%
WDR cells, PVN stimulation
C-fiber response change
−73.1%
WDR cells, PVN stimulation
Post-discharge change
−75%
WDR cells, PVN stimulation
Source sentences
Summary
PVN electrical stimulation inhibits Adelta (-55.0+/-10.2%), C-fiber (-73.1+/-6.7%), and post-discharge (-75.0+/-8.9%) peripheral activation in WDR cells
1 context sentence(design, population, supporting numbers)
Summary · context
In anaesthetized rats, we tested whether the unit activity of dorsal horn neurons that receive nociceptive input is modulated by electrical stimulation of the hypothalamic paraventricular nucleus (PVN).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1722940501
02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anaesthetized rats, intrathecal oxytocin antagonist or bicuculline blocked the inhibition of WDR cell peripheral responses caused by PVN stimulation.
In plain wordsIn anaesthetized rats, blocking oxytocin receptors or GABA receptors in the spinal cord stopped the pain-signal reduction caused by PVN stimulation.
Peptide
Oxytocin
Outcome
Not applicableBlock of PVN-induced inhibition in WDR cells by an oxytocin antagonist
Study
ratn: not reported in source
Anaesthetized rats, dorsal horn neuron recordings with PVN stimulation
Outcome group
Pain · Nervous system and cognition
Source sentences
Summary
In WDR cells, the inhibition of peripheral responses caused by PVN stimulation was blocked by intrathecal administration of a specific oxytocin antagonist or bicuculline.
1 context sentence(design, population, supporting numbers)
Summary · context
In anaesthetized rats, we tested whether the unit activity of dorsal horn neurons that receive nociceptive input is modulated by electrical stimulation of the hypothalamic paraventricular nucleus (PVN).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1722940502
03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anaesthetized rats, the oxytocin antagonist blocked PVN-ON cell activation, but bicuculline did not.
In plain wordsIn anaesthetized rats, an oxytocin blocker stopped activation of a type of spinal cell, but a GABA blocker did not.
Peptide
Oxytocin
Outcome
Not applicableBlock of PVN-ON cell activation by an oxytocin antagonist
Study
ratn: not reported in source
Anaesthetized rats, dorsal horn neuron recordings with PVN stimulation
Outcome group
Pain · Nervous system and cognition
Source sentences
Summary
However, PVN-ON cell activation was blocked by the same specific oxytocin antagonist, but not by bicuculline.
1 context sentence(design, population, supporting numbers)
Summary · context
In anaesthetized rats, we tested whether the unit activity of dorsal horn neurons that receive nociceptive input is modulated by electrical stimulation of the hypothalamic paraventricular nucleus (PVN).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1722940503
04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In anaesthetized rats, electrical stimulation of the paraventricular nucleus activated typically silent dorsal horn interneurons, called PVN-ON cells.
In plain wordsIn anaesthetized rats, stimulating a brain area called the PVN switched on a group of normally silent spinal cord cells.
Peptide
Oxytocin
Outcome
IncreaseActivation of silent interneurons (PVN-ON cells) by PVN stimulation
Study
ratn: not reported in source
Anaesthetized rats, dorsal horn neuron recordings with PVN stimulation
Outcome group
Pain · Nervous system and cognition
Source sentences
Summary
PVN electrical stimulation inhibits Adelta (-55.0+/-10.2%), C-fiber (-73.1+/-6.7%), and post-discharge (-75.0+/-8.9%) peripheral activation in WDR cells, and silent interneurons were activated.
1 context sentence(design, population, supporting numbers)
Summary · context
In anaesthetized rats, we tested whether the unit activity of dorsal horn neurons that receive nociceptive input is modulated by electrical stimulation of the hypothalamic paraventricular nucleus (PVN).
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-1722940504

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:51 UTC
First added · source update from Europe PMC

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