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Study · Not a test of the peptide alone · 2007

2 results

Maternal obesity increases hypothalamic leptin receptor expression and sensitivity in juvenile obesity-prone rats.

Gorski JN, Dunn-Meynell AA, Levin BE

American journal of physiology. Regulatory, integrative and comparative physiology11 Jan 2007Cited by 49 (Europe PMC)

PMID17218441 (opens in a new tab)DOI10.1152/ajpregu.00749.2006 (opens in a new tab)PepBankPUB-17218441
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 01AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In juvenile rats, the anorectic response to melanotan II did not differ between offspring of obese DIO dams and offspring of lean DR or DIO dams.

    In plain wordsIn rats, offspring of obese mothers responded to melanotan II's appetite-reducing effect the same as offspring of lean mothers.

    Peptide
    Melanotan II
    Outcome
    No significant changeAnorectic response to MTII by maternal group
    Study

    ratn: not reported in source

    offspring of obese or lean DIO or DR dams
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    their anorectic and brown adipose thermogenic responses to the melanocortin agonist, Melanotan II (MTII), did not differ from those of offspring of lean DR or DIO dams.
    1 context sentence
    Summary · context
    In rats selectively bred to develop diet-induced obesity (DIO) or to be diet-resistant (DR), DIO maternal obesity selectively enhances the development of obesity and insulin resistance in their adult offspring.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

  2. 02AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In juvenile rats, the brown adipose thermogenic response to melanotan II did not differ between offspring of obese DIO dams and offspring of lean DR or DIO dams.

    In plain wordsIn rats, offspring of obese mothers showed the same brown fat heat response to melanotan II as offspring of lean mothers.

    Peptide
    Melanotan II
    Outcome
    No significant changeBrown adipose thermogenic response to MTII by maternal group
    Study

    ratn: not reported in source

    offspring of obese or lean DIO or DR dams
    Outcome group
    Receptor activity and mechanism · Metabolic and weight

    Source sentences

    Summary
    their anorectic and brown adipose thermogenic responses to the melanocortin agonist, Melanotan II (MTII), did not differ from those of offspring of lean DR or DIO dams.
    1 context sentence
    Summary · context
    In rats selectively bred to develop diet-induced obesity (DIO) or to be diet-resistant (DR), DIO maternal obesity selectively enhances the development of obesity and insulin resistance in their adult offspring.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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