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Study · Animal study (in vivo) · rat · 2006

3 results

[Intranasal epitalon infusion modulates neuronal activity in the rat neocortex].

Sibarov DA, Vol'nova AB, Frolov DS, Nosdrachev AD

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Aug 2006

PMID17217245 (opens in a new tab)PepBankPUB-17217245
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In anesthetized rats, intranasal epitalon raised the neuronal spike frequency in the motor cortex 2-2.5-fold within minutes.

    In plain wordsIn rats, epitalon given through the nose raised nerve cell firing in the motor cortex 2-2.5-fold within minutes.

    Peptide
    Epitalon
    Outcome
    IncreaseSpike frequency of motor cortex neurons
    Study

    ratn: not reported in source

    Urethane-anesthetized Wistar male rats, motor cortex
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2 ng · intranasalAs given in this study (rat).

    Measurements

    spike frequency increase
    2 to 2.5 fold
    after intranasal epitalon

    Source sentences

    Summary
    Within a few minutes after the infusion, significant activation of neural activity was observed (2-2.5-fold higher frequency of neuronal spikes).
    2 context sentences
    Summary · context
    Wistar male rats were anesthetized with urethane (1 g/kg).
    Summary · context
    After recording of spontaneous activity (10-15 min), epitalon intranasal infusion (2 ng) was followed by 30-minute recording.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In anesthetized rats, in some recordings the epitalon-induced rise in spike frequency came in several phases, at 5 to 7 min, 11-12 min and 17-18 min.

    In plain wordsIn rats, in some recordings the rise in nerve cell firing after nasal epitalon came in three phases over about 18 minutes.

    Peptide
    Epitalon
    Outcome
    Not applicablePhases of the neuronal response
    Study

    ratn: not reported in source

    Urethane-anesthetized Wistar male rats, motor cortex
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2 ng · intranasalAs given in this study (rat).

    Measurements

    first phase duration
    5 to 7 min
    after infusion
    second phase
    11 to 12 min
    after infusion
    third phase
    17 to 18 min
    after infusion

    Source sentences

    Summary
    Complex response consisting of several phases was identified in some recordings. The spikes frequency growth during 5 to 7 min (first phase) after the infusion was followed by the second (11-12 min) and the third (17-18 min) phases.
    2 context sentences
    Summary · context
    Wistar male rats were anesthetized with urethane (1 g/kg).
    Summary · context
    After recording of spontaneous activity (10-15 min), epitalon intranasal infusion (2 ng) was followed by 30-minute recording.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In anesthetized rats, the rise in spontaneous activity came from higher firing frequency of already active units and the involvement of previously silent cells.

    In plain wordsIn rats, the rise in nerve cell firing came from active cells firing more and from silent cells starting to fire.

    Peptide
    Epitalon
    Outcome
    IncreaseRecruitment of active and silent neurons
    Study

    ratn: not reported in source

    Urethane-anesthetized Wistar male rats, motor cortex
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2 ng · intranasalAs given in this study (rat).

    Source sentences

    Summary
    An increase of neuronal spontaneous activity was conditioned by the higher frequency of already active units and by the involvement of previously silent cells.
    2 context sentences
    Summary · context
    Wistar male rats were anesthetized with urethane (1 g/kg).
    Summary · context
    After recording of spontaneous activity (10-15 min), epitalon intranasal infusion (2 ng) was followed by 30-minute recording.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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