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Study · Ex vivo tissue · chicken · 2008

9 results

Effects of ghrelin and its analogues on chicken ovarian granulosa cells.

Sirotkin AV, Grossmann R

Domestic animal endocrinology20 Dec 2006Cited by 25 (Europe PMC)

PMID17207955 (opens in a new tab)DOI10.1016/j.domaniend.2006.11.005 (opens in a new tab)PepBankPUB-17207955
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In isolated chicken ovarian follicular fragments, GHRP6 stimulated progesterone secretion.

    In plain wordsIn lab tests on chicken ovarian tissue, GHRP6 increased progesterone release.

    Peptide
    GHRP-6
    Outcome
    IncreaseProgesterone secretion
    Study

    chickenn: not reported in source

    isolated chicken ovarian follicular fragments
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Secretion of P(4) by ovarian follicular fragments was decreased after addition of ghrelin 1-28 or ghrelin 1-5 but stimulated by GHRP6 and ghrelin 1-18.
    1 context sentence
    Summary · context
    We compared the effect of full-length ghrelin 1-28, a synthetic activator of GHS-R1a, GHRP6, and ghrelin molecular fragments 1-18 and 1-5 on cultured chicken ovarian cells.
  2. 02LabEx vivo tissueActivity measurement

    In isolated chicken ovarian follicular fragments, GHRP6 did not inhibit testosterone secretion.

    In plain wordsIn lab tests on chicken ovarian tissue, GHRP6 did not change testosterone release.

    Peptide
    GHRP-6
    Outcome
    No significant changeTestosterone secretion
    Study

    chickenn: not reported in source

    isolated chicken ovarian follicular fragments
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Testosterone secretion was inhibited by ghrelins 1-28 and 1-18, but not by GHRP6 or ghrelin 1-5.
    1 context sentence
    Summary · context
    We compared the effect of full-length ghrelin 1-28, a synthetic activator of GHS-R1a, GHRP6, and ghrelin molecular fragments 1-18 and 1-5 on cultured chicken ovarian cells.
  3. 03LabEx vivo tissueActivity measurement

    In isolated chicken ovarian follicular fragments, GHRP6 had no effect on estradiol secretion.

    In plain wordsIn lab tests on chicken ovarian tissue, GHRP6 had no effect on estradiol release.

    Peptide
    GHRP-6
    Outcome
    No significant changeEstradiol secretion
    Study

    chickenn: not reported in source

    isolated chicken ovarian follicular fragments
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Estradiol secretion was reduced after treatment with ghrelin 1-28 but stimulated by ghrelins 1-18 and 1-5; GHRP6 had no effect.
    1 context sentence
    Summary · context
    We compared the effect of full-length ghrelin 1-28, a synthetic activator of GHS-R1a, GHRP6, and ghrelin molecular fragments 1-18 and 1-5 on cultured chicken ovarian cells.
  4. 04LabEx vivo tissueActivity measurement

    In isolated chicken ovarian follicular fragments, GHRP6 stimulated secretion of arginine-vasotocin.

    In plain wordsIn lab tests on chicken ovarian tissue, GHRP6 increased release of the hormone arginine-vasotocin.

    Peptide
    GHRP-6
    Outcome
    IncreaseArginine-vasotocin secretion
    Study

    chickenn: not reported in source

    isolated chicken ovarian follicular fragments
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    AVT secretion was stimulated by ghrelin 1-28, GHRP6 and ghrelin 1-18, but inhibited by ghrelin 1-5.
    1 context sentence
    Summary · context
    We compared the effect of full-length ghrelin 1-28, a synthetic activator of GHS-R1a, GHRP6, and ghrelin molecular fragments 1-18 and 1-5 on cultured chicken ovarian cells.
  5. 05LabIn vitro (cells)Mechanism

    In cultured chicken ovarian granulosa cells, GHRP6 increased accumulation of the apoptotic peptide bax.

    In plain wordsIn chicken ovarian cells, GHRP6 increased a marker of cell death called bax.

    Peptide
    GHRP-6
    Outcome
    IncreaseBax accumulation
    Study

    chickenn: not reported in source

    cultured chicken ovarian granulosa cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It was observed that accumulation of bax was increased by ghrelin 1-28, GHRP6 and ghrelin 1-18, but not by ghrelin 1-5.
    1 context sentence
    Summary · context
    We compared the effect of full-length ghrelin 1-28, a synthetic activator of GHS-R1a, GHRP6, and ghrelin molecular fragments 1-18 and 1-5 on cultured chicken ovarian cells.
  6. 06LabIn vitro (cells)Mechanism

    In cultured chicken ovarian granulosa cells, GHRP6 suppressed expression of the anti-apoptotic peptide bcl-2.

    In plain wordsIn chicken ovarian cells, GHRP6 lowered a protein that protects cells from death.

    Peptide
    GHRP-6
    Outcome
    DecreaseBcl-2 expression
    Study

    chickenn: not reported in source

    cultured chicken ovarian granulosa cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Expression of bcl-2 was suppressed by addition of ghrelin 1-28, GHRP6 and ghrelin 1-5, but promoted by ghrelin 1-18.
    1 context sentence
    Summary · context
    We compared the effect of full-length ghrelin 1-28, a synthetic activator of GHS-R1a, GHRP6, and ghrelin molecular fragments 1-18 and 1-5 on cultured chicken ovarian cells.
  7. 07LabIn vitro (cells)Mechanism

    In cultured chicken ovarian granulosa cells, GHRP6 reduced the occurrence of the proliferation marker PCNA.

    In plain wordsIn chicken ovarian cells, GHRP6 lowered a marker of cell growth.

    Peptide
    GHRP-6
    Outcome
    DecreasePCNA expression (proliferation)
    Study

    chickenn: not reported in source

    cultured chicken ovarian granulosa cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The occurrence of PCNA was reduced by ghrelin 1-28, GHRP6, ghrelin 1-18 and ghrelin 1-5.
    1 context sentence
    Summary · context
    We compared the effect of full-length ghrelin 1-28, a synthetic activator of GHS-R1a, GHRP6, and ghrelin molecular fragments 1-18 and 1-5 on cultured chicken ovarian cells.
  8. 08LabIn vitro (cells)Mechanism

    In cultured chicken ovarian granulosa cells, GHRP6 increased expression of MAPK/ERK1, 2.

    In plain wordsIn chicken ovarian cells, GHRP6 increased a signalling protein called MAPK.

    Peptide
    GHRP-6
    Outcome
    IncreaseMAPK/ERK1,2 expression
    Study

    chickenn: not reported in source

    cultured chicken ovarian granulosa cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    An increase in the expression of MAPK/ERK1, 2 was observed after addition of ghrelin 1-28, GHRP6 and ghrelin 1-18, but not ghrelin 1-5.
    1 context sentence
    Summary · context
    We compared the effect of full-length ghrelin 1-28, a synthetic activator of GHS-R1a, GHRP6, and ghrelin molecular fragments 1-18 and 1-5 on cultured chicken ovarian cells.
  9. 09LabIn vitro (cells)Mechanism

    In cultured chicken ovarian granulosa cells, GHRP6 increased accumulation of PKA.

    In plain wordsIn chicken ovarian cells, GHRP6 increased a signalling protein called PKA.

    Peptide
    GHRP-6
    Outcome
    IncreasePKA accumulation
    Study

    chickenn: not reported in source

    cultured chicken ovarian granulosa cells
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The accumulation of PKA decreased after treatment with ghrelin 1-28 and increased after treatment with GHRP6 and ghrelin 1-18 but not ghrelin 1-5.
    1 context sentence
    Summary · context
    We compared the effect of full-length ghrelin 1-28, a synthetic activator of GHS-R1a, GHRP6, and ghrelin molecular fragments 1-18 and 1-5 on cultured chicken ovarian cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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