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Study · Animal study (in vivo) · rat · 2006

4 results

Valproate and delta-sleep peptide display high efficacy against metaphit-induced audiogenic seizure in rats.

Stanojlović O, Hrncić D, Zivanović D, Rasić A, Susić V

Acta physiologica Hungarica1 Dec 2006

PMID17191662 (opens in a new tab)DOI10.1556/aphysiol.93.2006.4.6 (opens in a new tab)PepBankPUB-17191662
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats with metaphit-induced audiogenic seizures, DSIP reduced seizure incidence in a dose-dependent manner.

    In plain wordsIn rats with induced seizures, DSIP lowered how often seizures happened, with bigger doses working more.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseSeizure incidence
    Study

    ratn: not reported in source

    metaphit-induced audiogenic seizure
    Outcome group
    Seizures · Nervous system and cognition
    Studied dose
    0.1-1.0 mg kg(-1) · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Valproate and DSIP reduced the incidence of seizure and prolonged duration of latency in a dose-dependent manner.
    2 context sentences
    Summary · context
    The effects of valproate (VPA) and delta sleep-inducing peptide (DSIP) on metaphit-induced generalized, audiogenic seizure in adult rat males were compared.
    Summary · context
    The animals were i.p. injected with: (1) Saline; (2) metaphit (mp, 10 mg kg(-1)); 3. metaphit (10 mg kg(-1)) and 8 h later with DSIP (0.1, 0.2, 0.4 or 1.0 mg kg(-1)), 4. metaphit (10 mg kg(-1)) and 8 h later with VPA (50, 75 or 100 mg kg(-1)); 5.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult male rats with metaphit-induced audiogenic seizures, DSIP prolonged seizure latency in a dose-dependent manner.

    In plain wordsIn rats with induced seizures, DSIP delayed the start of seizures, with bigger doses working more.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSeizure latency
    Study

    ratn: not reported in source

    metaphit-induced audiogenic seizure
    Outcome group
    Seizures · Nervous system and cognition
    Studied dose
    0.1-1.0 mg kg(-1) · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Valproate and DSIP reduced the incidence of seizure and prolonged duration of latency in a dose-dependent manner.
    2 context sentences
    Summary · context
    The effects of valproate (VPA) and delta sleep-inducing peptide (DSIP) on metaphit-induced generalized, audiogenic seizure in adult rat males were compared.
    Summary · context
    The animals were i.p. injected with: (1) Saline; (2) metaphit (mp, 10 mg kg(-1)); 3. metaphit (10 mg kg(-1)) and 8 h later with DSIP (0.1, 0.2, 0.4 or 1.0 mg kg(-1)), 4. metaphit (10 mg kg(-1)) and 8 h later with VPA (50, 75 or 100 mg kg(-1)); 5.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In rats with metaphit-induced audiogenic seizures, the ED50 of DSIP was 3.19 mg kg(-1) four hours after injection.

    In plain wordsIn rats with induced seizures, DSIP had a half-maximal effective dose of 3.19 mg per kg four hours after injection.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableED50 against metaphit seizure
    Study

    ratn: not reported in source

    metaphit-induced audiogenic seizure
    Outcome group
    Seizures · Nervous system and cognition
    Studied dose
    0.1-1.0 mg kg(-1) · intraperitonealAs given in this study (rat).

    Measurements

    ED50
    3.19 mg kg(-1)
    DSIP, four hours after injection

    Source sentences

    Summary
    ED50 of valproate in the 1st hour after administration was 63.19 mg kg(-1) and that of DSIP 3.19 mg kg(-1) four hours after injection.
    2 context sentences
    Summary · context
    The effects of valproate (VPA) and delta sleep-inducing peptide (DSIP) on metaphit-induced generalized, audiogenic seizure in adult rat males were compared.
    Summary · context
    The animals were i.p. injected with: (1) Saline; (2) metaphit (mp, 10 mg kg(-1)); 3. metaphit (10 mg kg(-1)) and 8 h later with DSIP (0.1, 0.2, 0.4 or 1.0 mg kg(-1)), 4. metaphit (10 mg kg(-1)) and 8 h later with VPA (50, 75 or 100 mg kg(-1)); 5.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with metaphit-induced seizures, no DSIP dose eliminated the epileptiform EEG signs.

    In plain wordsIn rats with induced seizures, no DSIP dose removed the abnormal brain-wave signs of seizure activity.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeEpileptiform EEG signs
    Study

    ratn: not reported in source

    metaphit-induced audiogenic seizure
    Outcome group
    Seizures · Nervous system and cognition
    Studied dose
    0.1-1.0 mg kg(-1) · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    None of the applied VPA and DSIP doses eliminated the metaphit-provoked EEG signs of epileptiform activity.
    2 context sentences
    Summary · context
    The effects of valproate (VPA) and delta sleep-inducing peptide (DSIP) on metaphit-induced generalized, audiogenic seizure in adult rat males were compared.
    Summary · context
    The animals were i.p. injected with: (1) Saline; (2) metaphit (mp, 10 mg kg(-1)); 3. metaphit (10 mg kg(-1)) and 8 h later with DSIP (0.1, 0.2, 0.4 or 1.0 mg kg(-1)), 4. metaphit (10 mg kg(-1)) and 8 h later with VPA (50, 75 or 100 mg kg(-1)); 5.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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