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Study · Not a test of the peptide alone · 2007

3 results

Synthesis, characterization and in vitro cytotoxicity studies of a macromolecular conjugate of paclitaxel bearing oxytocin as targeting moiety.

Cavallaro G, Maniscalco L, Campisi M, Schillaci D, Giammona G

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V21 Oct 2006Cited by 19 (Europe PMC)

PMID17182230 (opens in a new tab)DOI10.1016/j.ejpb.2006.10.013 (opens in a new tab)PepBankPUB-17182230
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneIn vitro (cells)Activity measurement

    In MCF-7 cells, the oxytocin-bearing paclitaxel polymer conjugate had the same cell growth inhibition as free drug.

    In plain wordsIn breast cancer cells in the lab, the oxytocin-bearing conjugate stopped growth as well as the free drug.

    Peptide
    Oxytocin
    Outcome
    No significant changeAntiproliferative activity against MCF-7 cells
    Study

    humann: not reported in source

    MCF-7 cells, oxytocin receptor positive
    Comparator
    Free paclitaxel
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Moreover, preliminary in vitro antiproliferative studies, carried out on MCF-7 cells, that are oxytocin receptor positive cells, showed that the polymeric conjugate has the same cell growing inhibition ability of free drug.
    1 context sentence
    Summary · context
    The present study describes the experimental synthetic procedure and the characterization of a new polyaspartamide macromolecular prodrug of paclitaxel, bearing oxytocin residues as targeting moieties.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneIn vitro (cell-free)Other

    In buffer and human plasma, the linkage between oxytocin and the polymer in a paclitaxel conjugate was highly stable.

    In plain wordsIn lab tests, the link between oxytocin and the polymer in the paclitaxel conjugate stayed stable in buffer and plasma.

    Peptide
    Oxytocin
    Outcome
    Not applicableStability of oxytocin-polymer linkage in conjugate
    Study

    n: not reported in source

    Buffer solutions at pH 7.4 and 5.5 and human plasma
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    the high stability of the targeting portion (oxytocin)-polymer linkage
    1 context sentence
    Summary · context
    The present study describes the experimental synthetic procedure and the characterization of a new polyaspartamide macromolecular prodrug of paclitaxel, bearing oxytocin residues as targeting moieties.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Oxytocin aloneIn vitro (cell-free)Pharmacokinetics

    In human plasma, the oxytocin-bearing paclitaxel conjugate released linked paclitaxel in a prolonged way.

    In plain wordsIn lab tests, the oxytocin-bearing paclitaxel conjugate released paclitaxel slowly in human plasma.

    Peptide
    Oxytocin
    Outcome
    Not applicableProlonged release of paclitaxel from conjugate in plasma
    Study

    n: not reported in source

    Buffer solutions at pH 7.4 and 5.5 and human plasma
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    the ability of this conjugate to release linked paclitaxel in a prolonged way in plasma.
    1 context sentence
    Summary · context
    The present study describes the experimental synthetic procedure and the characterization of a new polyaspartamide macromolecular prodrug of paclitaxel, bearing oxytocin residues as targeting moieties.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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