Luteinizing hormone release after administration of the gonadotropin-releasing hormone agonist Fertilan (goserelin) for synchronization of ovulation in pigs.

Brüssow KP, Schneider F, Tuchscherer A, Rátky J, Kraeling RR, Kanitz W

Journal of animal science1 Jan 2007Cited by 13 (Europe PMC)

PMID17179548DOI10.2527/jas.2006-281PepBankPUB-17179548

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study16

16 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In gilts, ovulation occurred later with Fertilan than Gonavet (P < 0.05); time of ovulation ranged from 34 to 42 h postGnRH.
In plain wordsIn pigs, ovulation occurred later with Fertilan than Gonavet.
Peptide
Goserelin
Outcome
IncreaseTime of ovulation
Study
pign = 12
estrus-synchronized gilts
Comparator
50 microg Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 microg · injectionAs given in this study (pig).
Source sentences
Summary
Time of ovulation ranged from 34 to 42 h postGnRH; however, ovulation occurred earlier in the Gonavet compared with the other groups (P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
3, estrus-synchronized gilts were injected with 20 microg of Fertilan (n = 8) or 50 microg of Gonavet (n = 4), and the time of ovulation was determined by repeated endoscopic examination.
Report a problemFND-1717954816
02AnimalAnimal study (in vivo)Efficacy outcome
In barrows, Fertilan caused dose-dependent stimulation of LH release (P < 0.05).
In plain wordsIn pigs, Fertilan stimulated LH release in a dose-dependent manner.
Peptide
Goserelin
Outcome
IncreaseDose-dependent LH release in barrows
Study
pign = 10
barrows
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10, 20, or 40 microg · injectionAs given in this study (pig).
Source sentences
Summary
There was a dose-dependent stimulation (P < 0.05) of LH release.
1 context sentence(design, population, supporting numbers)
Summary · context
1, 10 barrows were injected on d 1, 4, 7, 10, and 13 with 10, 20, or 40 microg of Fertilan; 50 microg of Gonavet (depherelin; GnRH control) or saline (negative control); and sequential blood samples were collected for 480 min.
Report a problemFND-1717954801
03AnimalAnimal study (in vivo)Efficacy outcome
In estrus-synchronized gilts, an LH surge occurred in 3 of 4 animals given 10 microg Fertilan versus all 4 given Gonavet.
In plain wordsIn pigs, an LH surge occurred in 3 of 4 given 10 microg Fertilan versus all 4 given Gonavet.
Peptide
Goserelin
Outcome
Not applicableLH surge at 10 microg in gilts
Study
pign = 8
estrus-synchronized gilts
Comparator
50 microg Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 microg · injectionAs given in this study (pig).
Source sentences
Summary
An LH surge was induced in 3 of the 4 gilts in both of the Fertilan groups and in all of the Gonavet-treated gilts.
1 context sentence(design, population, supporting numbers)
Summary · context
2, 12 gilts received (after estrus synchronization with Regumate and eCG) injections of 10 or 20 microg of Fertilan or 50 microg of Gonavet 80 h after eCG to stimulate a preovulatory-like LH surge and ovulation.
Report a problemFND-1717954808
04AnimalAnimal study (in vivo)Efficacy outcome
In estrus-synchronized gilts, an LH surge occurred in 3 of 4 animals given 20 microg Fertilan versus all 4 given Gonavet.
In plain wordsIn pigs, an LH surge occurred in 3 of 4 given 20 microg Fertilan versus all 4 given Gonavet.
Peptide
Goserelin
Outcome
Not applicableLH surge at 20 microg in gilts
Study
pign = 8
estrus-synchronized gilts
Comparator
50 microg Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 microg · injectionAs given in this study (pig).
Source sentences
Summary
An LH surge was induced in 3 of the 4 gilts in both of the Fertilan groups and in all of the Gonavet-treated gilts.
1 context sentence(design, population, supporting numbers)
Summary · context
2, 12 gilts received (after estrus synchronization with Regumate and eCG) injections of 10 or 20 microg of Fertilan or 50 microg of Gonavet 80 h after eCG to stimulate a preovulatory-like LH surge and ovulation.
Report a problemFND-1717954809
05AnimalAnimal study (in vivo)Efficacy outcome
In barrows, maximum LH after Fertilan was 2.1 +/- 0.2 ng/mL at 10 microg.
In plain wordsIn pigs, maximum LH after Fertilan was 2.1 +/- 0.2 ng/mL at 10 microg.
Peptide
Goserelin
Outcome
Not applicableMaximum LH after 10 microg in barrows
Study
pign: not reported in source
barrows
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 microg · injectionAs given in this study (pig).
Source sentences
Summary
Maximal plasma concentrations of LH (LH(MAX)) were 2.1 +/- 0.2, 4.1 +/- 0.3, 2.6 +/- 0.4, and 3.4 +/- 0.3 ng/mL after 10, 20, and 40 microg of Fertilan and 50 microg of Gonavet, respectively,
Report a problemFND-1717954802
06AnimalAnimal study (in vivo)Efficacy outcome
In barrows, maximum LH after Fertilan was 4.1 +/- 0.3 ng/mL at 20 microg.
In plain wordsIn pigs, maximum LH after Fertilan was 4.1 +/- 0.3 ng/mL at 20 microg.
Peptide
Goserelin
Outcome
Not applicableMaximum LH after 20 microg in barrows
Study
pign: not reported in source
barrows
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 microg · injectionAs given in this study (pig).
Source sentences
Summary
Maximal plasma concentrations of LH (LH(MAX)) were 2.1 +/- 0.2, 4.1 +/- 0.3, 2.6 +/- 0.4, and 3.4 +/- 0.3 ng/mL after 10, 20, and 40 microg of Fertilan and 50 microg of Gonavet, respectively,
Report a problemFND-1717954803
07AnimalAnimal study (in vivo)Efficacy outcome
In barrows, maximum LH after Fertilan was 2.6 +/- 0.4 ng/mL at 40 microg.
In plain wordsIn pigs, maximum LH after Fertilan was 2.6 +/- 0.4 ng/mL at 40 microg.
Peptide
Goserelin
Outcome
Not applicableMaximum LH after 40 microg in barrows
Study
pign: not reported in source
barrows
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
40 microg · injectionAs given in this study (pig).
Source sentences
Summary
Maximal plasma concentrations of LH (LH(MAX)) were 2.1 +/- 0.2, 4.1 +/- 0.3, 2.6 +/- 0.4, and 3.4 +/- 0.3 ng/mL after 10, 20, and 40 microg of Fertilan and 50 microg of Gonavet, respectively,
Report a problemFND-1717954804
08AnimalAnimal study (in vivo)Efficacy outcome
In barrows, LH release lasted 78 +/- 9 min after 10 microg Fertilan.
In plain wordsIn pigs, LH release lasted 78 +/- 9 min after 10 microg Fertilan.
Peptide
Goserelin
Outcome
Not applicableLH release duration after 10 microg in barrows
Study
pign: not reported in source
barrows
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 microg · injectionAs given in this study (pig).
Source sentences
Summary
and duration of release was 78 +/- 9, 177 +/- 12, 138 +/- 7, and 180 +/- 11 min, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Maximal plasma concentrations of LH (LH(MAX)) were 2.1 +/- 0.2, 4.1 +/- 0.3, 2.6 +/- 0.4, and 3.4 +/- 0.3 ng/mL after 10, 20, and 40 microg of Fertilan and 50 microg of Gonavet, respectively,
Report a problemFND-1717954805
09AnimalAnimal study (in vivo)Efficacy outcome
In barrows, LH release lasted 177 +/- 12 min after 20 microg Fertilan.
In plain wordsIn pigs, LH release lasted 177 +/- 12 min after 20 microg Fertilan.
Peptide
Goserelin
Outcome
Not applicableLH release duration after 20 microg in barrows
Study
pign: not reported in source
barrows
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 microg · injectionAs given in this study (pig).
Source sentences
Summary
and duration of release was 78 +/- 9, 177 +/- 12, 138 +/- 7, and 180 +/- 11 min, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Maximal plasma concentrations of LH (LH(MAX)) were 2.1 +/- 0.2, 4.1 +/- 0.3, 2.6 +/- 0.4, and 3.4 +/- 0.3 ng/mL after 10, 20, and 40 microg of Fertilan and 50 microg of Gonavet, respectively,
Report a problemFND-1717954806
10AnimalAnimal study (in vivo)Efficacy outcome
In barrows, LH release lasted 138 +/- 7 min after 40 microg Fertilan.
In plain wordsIn pigs, LH release lasted 138 +/- 7 min after 40 microg Fertilan.
Peptide
Goserelin
Outcome
Not applicableLH release duration after 40 microg in barrows
Study
pign: not reported in source
barrows
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
40 microg · injectionAs given in this study (pig).
Source sentences
Summary
and duration of release was 78 +/- 9, 177 +/- 12, 138 +/- 7, and 180 +/- 11 min, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Maximal plasma concentrations of LH (LH(MAX)) were 2.1 +/- 0.2, 4.1 +/- 0.3, 2.6 +/- 0.4, and 3.4 +/- 0.3 ng/mL after 10, 20, and 40 microg of Fertilan and 50 microg of Gonavet, respectively,
Report a problemFND-1717954807
11AnimalAnimal study (in vivo)Efficacy outcome
In gilts, maximum LH was 5.0 +/- 0.9 ng/mL with 10 microg Fertilan versus 6.6 +/- 1.1 with Gonavet, without a group difference.
In plain wordsIn pigs, maximum LH did not differ between 10 microg Fertilan and Gonavet.
Peptide
Goserelin
Outcome
No significant changeMaximum LH at 10 microg in gilts
Study
pign: not reported in source
estrus-synchronized gilts
Comparator
50 microg Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 microg · injectionAs given in this study (pig).
Source sentences
Summary
Characteristics of induced release of LH did not differ among groups: LH(MAX), 5.0 +/- 0.9 vs. 4.6 +/- 1.8 vs. 6.6 +/- 1.1 ng/mL; duration, 11.7 +/- 2.0 vs. 12.3 +/- 2.2 vs. 14.3 +/- 0.5 h; interval from GnRH injection to LH(MAX), 4.0 +/- 2.0 vs. 6.7 +/- 1.3 vs. 5.8 +/- 1.6 h.
1 context sentence(design, population, supporting numbers)
Summary · context
2, 12 gilts received (after estrus synchronization with Regumate and eCG) injections of 10 or 20 microg of Fertilan or 50 microg of Gonavet 80 h after eCG to stimulate a preovulatory-like LH surge and ovulation.
Report a problemFND-1717954810
12AnimalAnimal study (in vivo)Efficacy outcome
In gilts, maximum LH was 4.6 +/- 1.8 ng/mL with 20 microg Fertilan versus 6.6 +/- 1.1 with Gonavet, without a group difference.
In plain wordsIn pigs, maximum LH did not differ between 20 microg Fertilan and Gonavet.
Peptide
Goserelin
Outcome
No significant changeMaximum LH at 20 microg in gilts
Study
pign: not reported in source
estrus-synchronized gilts
Comparator
50 microg Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 microg · injectionAs given in this study (pig).
Source sentences
Summary
Characteristics of induced release of LH did not differ among groups: LH(MAX), 5.0 +/- 0.9 vs. 4.6 +/- 1.8 vs. 6.6 +/- 1.1 ng/mL; duration, 11.7 +/- 2.0 vs. 12.3 +/- 2.2 vs. 14.3 +/- 0.5 h; interval from GnRH injection to LH(MAX), 4.0 +/- 2.0 vs. 6.7 +/- 1.3 vs. 5.8 +/- 1.6 h.
1 context sentence(design, population, supporting numbers)
Summary · context
2, 12 gilts received (after estrus synchronization with Regumate and eCG) injections of 10 or 20 microg of Fertilan or 50 microg of Gonavet 80 h after eCG to stimulate a preovulatory-like LH surge and ovulation.
Report a problemFND-1717954811
13AnimalAnimal study (in vivo)Efficacy outcome
In gilts, LH release lasted 11.7 +/- 2.0 h with 10 microg Fertilan versus 14.3 +/- 0.5 h with Gonavet, without a group difference.
In plain wordsIn pigs, LH release duration did not differ between 10 microg Fertilan and Gonavet.
Peptide
Goserelin
Outcome
No significant changeLH release duration at 10 microg in gilts
Study
pign: not reported in source
estrus-synchronized gilts
Comparator
50 microg Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 microg · injectionAs given in this study (pig).
Source sentences
Summary
Characteristics of induced release of LH did not differ among groups: LH(MAX), 5.0 +/- 0.9 vs. 4.6 +/- 1.8 vs. 6.6 +/- 1.1 ng/mL; duration, 11.7 +/- 2.0 vs. 12.3 +/- 2.2 vs. 14.3 +/- 0.5 h; interval from GnRH injection to LH(MAX), 4.0 +/- 2.0 vs. 6.7 +/- 1.3 vs. 5.8 +/- 1.6 h.
1 context sentence(design, population, supporting numbers)
Summary · context
2, 12 gilts received (after estrus synchronization with Regumate and eCG) injections of 10 or 20 microg of Fertilan or 50 microg of Gonavet 80 h after eCG to stimulate a preovulatory-like LH surge and ovulation.
Report a problemFND-1717954812
14AnimalAnimal study (in vivo)Efficacy outcome
In gilts, LH release lasted 12.3 +/- 2.2 h with 20 microg Fertilan versus 14.3 +/- 0.5 h with Gonavet, without a group difference.
In plain wordsIn pigs, LH release duration did not differ between 20 microg Fertilan and Gonavet.
Peptide
Goserelin
Outcome
No significant changeLH release duration at 20 microg in gilts
Study
pign: not reported in source
estrus-synchronized gilts
Comparator
50 microg Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 microg · injectionAs given in this study (pig).
Source sentences
Summary
Characteristics of induced release of LH did not differ among groups: LH(MAX), 5.0 +/- 0.9 vs. 4.6 +/- 1.8 vs. 6.6 +/- 1.1 ng/mL; duration, 11.7 +/- 2.0 vs. 12.3 +/- 2.2 vs. 14.3 +/- 0.5 h; interval from GnRH injection to LH(MAX), 4.0 +/- 2.0 vs. 6.7 +/- 1.3 vs. 5.8 +/- 1.6 h.
1 context sentence(design, population, supporting numbers)
Summary · context
2, 12 gilts received (after estrus synchronization with Regumate and eCG) injections of 10 or 20 microg of Fertilan or 50 microg of Gonavet 80 h after eCG to stimulate a preovulatory-like LH surge and ovulation.
Report a problemFND-1717954813
15AnimalAnimal study (in vivo)Efficacy outcome
In gilts, time to maximum LH was 4.0 +/- 2.0 h with 10 microg Fertilan versus 5.8 +/- 1.6 h with Gonavet, without a group difference.
In plain wordsIn pigs, time to maximum LH did not differ between 10 microg Fertilan and Gonavet.
Peptide
Goserelin
Outcome
No significant changeTime to maximum LH at 10 microg in gilts
Study
pign: not reported in source
estrus-synchronized gilts
Comparator
50 microg Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
10 microg · injectionAs given in this study (pig).
Source sentences
Summary
Characteristics of induced release of LH did not differ among groups: LH(MAX), 5.0 +/- 0.9 vs. 4.6 +/- 1.8 vs. 6.6 +/- 1.1 ng/mL; duration, 11.7 +/- 2.0 vs. 12.3 +/- 2.2 vs. 14.3 +/- 0.5 h; interval from GnRH injection to LH(MAX), 4.0 +/- 2.0 vs. 6.7 +/- 1.3 vs. 5.8 +/- 1.6 h.
1 context sentence(design, population, supporting numbers)
Summary · context
2, 12 gilts received (after estrus synchronization with Regumate and eCG) injections of 10 or 20 microg of Fertilan or 50 microg of Gonavet 80 h after eCG to stimulate a preovulatory-like LH surge and ovulation.
Report a problemFND-1717954814
16AnimalAnimal study (in vivo)Efficacy outcome
In gilts, time to maximum LH was 6.7 +/- 1.3 h with 20 microg Fertilan versus 5.8 +/- 1.6 h with Gonavet, without a group difference.
In plain wordsIn pigs, time to maximum LH did not differ between 20 microg Fertilan and Gonavet.
Peptide
Goserelin
Outcome
No significant changeTime to maximum LH at 20 microg in gilts
Study
pign: not reported in source
estrus-synchronized gilts
Comparator
50 microg Gonavet
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 microg · injectionAs given in this study (pig).
Source sentences
Summary
Characteristics of induced release of LH did not differ among groups: LH(MAX), 5.0 +/- 0.9 vs. 4.6 +/- 1.8 vs. 6.6 +/- 1.1 ng/mL; duration, 11.7 +/- 2.0 vs. 12.3 +/- 2.2 vs. 14.3 +/- 0.5 h; interval from GnRH injection to LH(MAX), 4.0 +/- 2.0 vs. 6.7 +/- 1.3 vs. 5.8 +/- 1.6 h.
1 context sentence(design, population, supporting numbers)
Summary · context
2, 12 gilts received (after estrus synchronization with Regumate and eCG) injections of 10 or 20 microg of Fertilan or 50 microg of Gonavet 80 h after eCG to stimulate a preovulatory-like LH surge and ovulation.
Report a problemFND-1717954815

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.