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Study · In vitro (cells) · 2007

5 results

A new pro-migratory activity on human myogenic precursor cells for a synthetic peptide within the E domain of the mechano growth factor.

Mills P, Lafrenière JF, Benabdallah BF, El Fahime el M, Tremblay JP

Experimental cell research7 Nov 2006Cited by 56 (Europe PMC)

PMID17156777 (opens in a new tab)DOI10.1016/j.yexcr.2006.10.032 (opens in a new tab)PepBankPUB-17156777
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In human myogenic precursor cells in vitro, the synthetic MGF-Ct24E peptide acted as a motogenic factor (promoted migration); the abstract also mentions in vivo work without detail.

    In plain wordsIn cells, a lab-made piece of MGF helped human muscle precursor cells to move.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMigration of human myogenic precursor cells
    Study

    humann: not reported in source

    Human myogenic precursor cells
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we demonstrated that this synthetic peptide is a motogenic factor for human precursor myogenic cells in vitro and in vivo.
    1 context sentence
    Summary · context
    The MGF isoform contains a C-terminal 24 amino acids peptide in the E domain (MGF-Ct24E) that has intrinsic properties.
  2. 02LabIn vitro (cells)Activity measurement

    In human myogenic cells, MGF-Ct24E peptide increased expression of u-PA, u-PAR and MMP-7.

    In plain wordsIn cells, the MGF-Ct24E peptide raised levels of three proteins linked to cell movement.

    Peptide
    MGF / PEG-MGF
    Outcome
    Increaseu-PA, u-PAR and MMP-7 expression
    Study

    humann: not reported in source

    Human myogenic precursor cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MGF-Ct24E peptide enhances the expression of u-PA, u-PAR and MMP-7
    1 context sentence
    Summary · context
    The MGF isoform contains a C-terminal 24 amino acids peptide in the E domain (MGF-Ct24E) that has intrinsic properties.
  3. 03LabIn vitro (cells)Activity measurement

    In human myogenic cells, MGF-Ct24E peptide reduced PAI-1 activity.

    In plain wordsIn cells, the MGF-Ct24E peptide lowered PAI-1 activity, which is linked to cell movement.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreasePAI-1 activity
    Study

    humann: not reported in source

    Human myogenic precursor cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    while reducing PAI-1 activity.
    1 context sentence
    Summary · context
    The MGF isoform contains a C-terminal 24 amino acids peptide in the E domain (MGF-Ct24E) that has intrinsic properties.
  4. 04LabIn vitro (cells)Activity measurement

    In human myogenic cells, MGF-Ct24E peptide had no effect on the gelatinases MMP-2 and MMP-9.

    In plain wordsIn cells, the MGF-Ct24E peptide did not change MMP-2 and MMP-9.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMMP-2 and MMP-9 gelatinases
    Study

    humann: not reported in source

    Human myogenic precursor cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    MGF-Ct24E peptide enhances the expression of u-PA, u-PAR and MMP-7 while reducing PAI-1 activity. Moreover, it has no effect on the gelatinases MMP-2 and -9.
    1 context sentence
    Summary · context
    The MGF isoform contains a C-terminal 24 amino acids peptide in the E domain (MGF-Ct24E) that has intrinsic properties.
  5. 05LabIn vitro (cells)Mechanism

    In human myogenic cells, results suggest that MGF-Ct24E peptide induces cell responses through a mechanism that does not involve the IGF-1 receptor.

    In plain wordsIn cells, results suggest the MGF-Ct24E peptide works without the IGF-1 receptor.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableIGF-1 receptor dependence of cell responses
    Study

    humann: not reported in source

    Human myogenic precursor cells
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, we present some results suggesting that the MGF-Ct24E peptide induces these cell responses through a mechanism that does not involve the IGF-1 receptor.
    1 context sentence
    Summary · context
    The MGF isoform contains a C-terminal 24 amino acids peptide in the E domain (MGF-Ct24E) that has intrinsic properties.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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