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Study · Animal study (in vivo) · rat · 2006

2 results

Morphochemical study of hippocampus of august rats after systemic treatment with amphetamine followed by injection of delta sleep-inducing peptide.

Gershtein LM, Sergutina AV, Rakhmanova VI

Bulletin of experimental biology and medicine1 Apr 2006

PMID17152373 (opens in a new tab)DOI10.1007/s10517-006-0201-5 (opens in a new tab)PepBankPUB-17152373
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In August rats given chronic amphetamine, a single DSIP injection did not reverse the larger CA3 neuronal cytoplasm and nuclear area.

    In plain wordsIn rats given amphetamine, one DSIP injection did not undo the enlarged brain cell areas caused by amphetamine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeHippocampal CA3 neuron cytoplasm and nucleus area
    Study

    ratn: not reported in source

    chronic amphetamine in August rats
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    60 microg/kg · single injectionAs given in this study (rat).

    Source sentences

    Summary
    These changes persisted after single injection of delta sleep-inducing peptide (60 microg/kg).
    1 context sentence
    Summary · context
    Quantitative interferometry showed that chronic amphetamine administration to August rats (2.5 mg/kg/day for 3 weeks) increased the area of neuronal cytoplasm and nuclei and content and concentrations of proteins in hippocampal CA3 neurons.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In August rats given chronic amphetamine, a single DSIP injection did not reverse the higher protein content and concentration in CA3 neurons.

    In plain wordsIn rats given amphetamine, one DSIP injection did not undo the higher protein levels in brain cells caused by amphetamine.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeHippocampal CA3 neuron protein content and concentration
    Study

    ratn: not reported in source

    chronic amphetamine in August rats
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    60 microg/kg · single injectionAs given in this study (rat).

    Source sentences

    Summary
    These changes persisted after single injection of delta sleep-inducing peptide (60 microg/kg).
    1 context sentence
    Summary · context
    Quantitative interferometry showed that chronic amphetamine administration to August rats (2.5 mg/kg/day for 3 weeks) increased the area of neuronal cytoplasm and nuclei and content and concentrations of proteins in hippocampal CA3 neurons.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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