In a cell-free assay, binding of Ala-Glu-Asp-Gly peptide to duplex DNA was associated with a hyperchromic effect, indicating local separation of the double helix.
In plain wordsIn lab tests without cells, the peptide AEDG binding to DNA was linked to a local opening of the double helix.
- Peptide
- Epitalon
- Outcome
- IncreaseHyperchromic effect on duplex DNA
- Study
n: not reported in source
poly(dA-dT):poly(dA-dT) duplex DNA- Outcome group
- Receptor activity and mechanism · Pharmacology
- Studied dose
- Dose not stated
Source sentences
Peptide binding to duplex DNA was associated with hyperchromic effect indicating local separation of the double helix.
1 context sentence(design, population, supporting numbers)
Formation of Ala-Glu-Asp-Gly peptide complex with duplex DNA [poly(dA-dT):poly(dA-dT)] at neutral pH and ambient temperature was studied experimentally.