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Study · Animal study (in vivo) · rat · 2007

6 results

Impact of proestrous milieu on expression of orexin receptors and prepro-orexin in rat hypothalamus and hypophysis: actions of Cetrorelix and Nembutal.

Silveyra P, Catalano PN, Lux-Lantos V, Libertun C

American journal of physiology. Endocrinology and metabolism22 Nov 2006Cited by 72 (Europe PMC)

PMID17122088 (opens in a new tab)DOI10.1152/ajpendo.00467.2006 (opens in a new tab)PepBankPUB-17122088
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In proestrous rats, cetrorelix prevented the increase in pituitary OX1 expression.

    In plain wordsIn rats, cetrorelix prevented the rise in pituitary OX1 expression.

    Peptide
    Cetrorelix
    Outcome
    DecreasePituitary OX1 expression
    Study

    ratn: not reported in source

    Sprague-Dawley female cycling rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cetrorelix or pentobarbital prevented increases of OX1 and OX2 only in the pituitary and blunted gonadotropin surges, but left OX1, OX2, and PPO brain expression unchanged.
    2 context sentences
    Summary · context
    Primarily, PPO, OX1, and OX2 expression was determined in Sprague-Dawley female cycling rats during proestrus and in males.
    Summary · context
    Finally, OX1, OX2, and PPO were measured by real-time RT-PCR in tissues collected at 1900 of proestrus after treatments at 1400 with ovulation-blocking agents Cetrorelix or pentobarbital.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In proestrous rats, cetrorelix prevented the increase in pituitary OX2 expression.

    In plain wordsIn rats, cetrorelix prevented the rise in pituitary OX2 expression.

    Peptide
    Cetrorelix
    Outcome
    DecreasePituitary OX2 expression
    Study

    ratn: not reported in source

    Sprague-Dawley female cycling rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cetrorelix or pentobarbital prevented increases of OX1 and OX2 only in the pituitary and blunted gonadotropin surges, but left OX1, OX2, and PPO brain expression unchanged.
    2 context sentences
    Summary · context
    Primarily, PPO, OX1, and OX2 expression was determined in Sprague-Dawley female cycling rats during proestrus and in males.
    Summary · context
    Finally, OX1, OX2, and PPO were measured by real-time RT-PCR in tissues collected at 1900 of proestrus after treatments at 1400 with ovulation-blocking agents Cetrorelix or pentobarbital.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In proestrous rats, cetrorelix blunted gonadotropin surges.

    In plain wordsIn rats, cetrorelix reduced gonadotropin surges.

    Peptide
    Cetrorelix
    Outcome
    DecreaseGonadotropin surges
    Study

    ratn: not reported in source

    Sprague-Dawley female cycling rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cetrorelix or pentobarbital prevented increases of OX1 and OX2 only in the pituitary and blunted gonadotropin surges, but left OX1, OX2, and PPO brain expression unchanged.
    2 context sentences
    Summary · context
    Primarily, PPO, OX1, and OX2 expression was determined in Sprague-Dawley female cycling rats during proestrus and in males.
    Summary · context
    Finally, OX1, OX2, and PPO were measured by real-time RT-PCR in tissues collected at 1900 of proestrus after treatments at 1400 with ovulation-blocking agents Cetrorelix or pentobarbital.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In proestrous rats, cetrorelix left brain OX1 expression unchanged.

    In plain wordsIn rats, cetrorelix did not change brain OX1 expression.

    Peptide
    Cetrorelix
    Outcome
    No significant changeBrain OX1 expression
    Study

    ratn: not reported in source

    Sprague-Dawley female cycling rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cetrorelix or pentobarbital prevented increases of OX1 and OX2 only in the pituitary and blunted gonadotropin surges, but left OX1, OX2, and PPO brain expression unchanged.
    2 context sentences
    Summary · context
    Primarily, PPO, OX1, and OX2 expression was determined in Sprague-Dawley female cycling rats during proestrus and in males.
    Summary · context
    Finally, OX1, OX2, and PPO were measured by real-time RT-PCR in tissues collected at 1900 of proestrus after treatments at 1400 with ovulation-blocking agents Cetrorelix or pentobarbital.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In proestrous rats, cetrorelix left brain OX2 expression unchanged.

    In plain wordsIn rats, cetrorelix did not change brain OX2 expression.

    Peptide
    Cetrorelix
    Outcome
    No significant changeBrain OX2 expression
    Study

    ratn: not reported in source

    Sprague-Dawley female cycling rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cetrorelix or pentobarbital prevented increases of OX1 and OX2 only in the pituitary and blunted gonadotropin surges, but left OX1, OX2, and PPO brain expression unchanged.
    2 context sentences
    Summary · context
    Primarily, PPO, OX1, and OX2 expression was determined in Sprague-Dawley female cycling rats during proestrus and in males.
    Summary · context
    Finally, OX1, OX2, and PPO were measured by real-time RT-PCR in tissues collected at 1900 of proestrus after treatments at 1400 with ovulation-blocking agents Cetrorelix or pentobarbital.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In proestrous rats, cetrorelix left brain PPO expression unchanged.

    In plain wordsIn rats, cetrorelix did not change brain PPO expression.

    Peptide
    Cetrorelix
    Outcome
    No significant changeBrain PPO expression
    Study

    ratn: not reported in source

    Sprague-Dawley female cycling rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cetrorelix or pentobarbital prevented increases of OX1 and OX2 only in the pituitary and blunted gonadotropin surges, but left OX1, OX2, and PPO brain expression unchanged.
    2 context sentences
    Summary · context
    Primarily, PPO, OX1, and OX2 expression was determined in Sprague-Dawley female cycling rats during proestrus and in males.
    Summary · context
    Finally, OX1, OX2, and PPO were measured by real-time RT-PCR in tissues collected at 1900 of proestrus after treatments at 1400 with ovulation-blocking agents Cetrorelix or pentobarbital.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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