In nude mice, neonatal thymulin gene therapy completely or partly prevented altered liver phospholipid 22:6n-3 content.
In plain wordsIn nude mice, thymulin gene therapy partly or completely prevented altered liver phospholipid 22:6n-3 content compared with control vector.
- Outcome
- DecreaseLiver phospholipid 22:6n-3 alteration
- Study
mousen: not reported in source
Neonatal thymulin gene therapy in nude mice- Comparator
- Control vector
- Outcome group
- Lipids · Liver
Source sentences
Some of these alterations, such as that in the relative content of 22:6n-3 in liver PL and the unsaturation index, were completely or partially prevented by neonatal thymulin gene therapy.
3 context sentences(design, population, supporting numbers)
We constructed a recombinant adenoviral vector, RAd-metFTS, expressing a synthetic DNA sequence encoding met-FTS, an analog of the thymic peptide facteur thymique sérique (FTS), whose Zn-bound biologically active form is known as thymulin.
On postnatal day 1-2 homozygous (nu/nu) nude and heterozygous (nu/+) mice were injected with 10(8) pfu of RAd-metFTS or RAd-betagal (control vector) intramuscularly.
The animals were processed at 52 d of age.
In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).